3.4.21.B39: stratum corneum tryptic enzyme

This is an abbreviated version!
For detailed information about stratum corneum tryptic enzyme, go to the full flat file.

Reaction

proteolytic cleavage of polypeptides =

Synonyms

GK-5, hK5, HSC tryptic enzyme, human kallikrein 5, human stratum corneum trypsin-like enzyme, human tissue kallikrein 5, K5, kallikrein 5, kallikrein protein 5, kallikrein-5, kallikrein-like protein 2, kallikrein-related peptidase 5, KLK-L2, KLK5, More, S01.017, SCTE, strateum-corneum trypsin-like serine protease, stratum corneum tryptic enzyme, tissue kallikrein, tissue kallikrein 5

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B39 stratum corneum tryptic enzyme

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Results	in table
7	Activating Compound
3	AA Sequence
6	Application
2	CAS Registry Number
13	Cloned(Commentary)
3	Crystallization (Commentary)
237	Disease/ Diagnostics
6	Expression
11	General Information
8	IC50 Value
51	Inhibitors
1	kcat/KM [mM/s]
17	Ki Value [mM]
20	KM Value [mM]
3	Localization
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
43	Organism
6	pH Optimum
1	pH Range
6	Posttranslational Modification
1	Protein Variants
8	Purification (Commentary)
6	Reaction
8	Reaction Type
41	Reference
105	Source Tissue
1	Storage Stability
98	Substrates and Products (Substrate)
2	Subunits
72	Synonyms
3	Temperature Optimum [°C]
18	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.21.B39 - stratum corneum tryptic enzyme

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

cloned from a keratinocyte library, DNA sequence determination and analysis, expression in CHO-K1 cells via infection with Semliki Forest Virus system

Homo sapiens

Q9Y337

647353

cloned from RNA isolated from HaCaT cells, expression as His-tagged enzyme in Escherichia coli BL21(DE3)

Homo sapiens

Q9Y337

647354

DNA sequence determination and analysis, expression in CHO-CCL-61 cells, in Escherichia coli, and in Pichia pastoris

Homo sapiens

Q9Y337

647355

expressed in a baculovirus-insect cell system

Homo sapiens

Q9Y337

681454

expressed in Escherichia coli strain BL21

Mus musculus

-

683017

expressed in insect cell/baculovirus expression system

Homo sapiens

-

717354

expressed in insect cells

Homo sapiens

Q9Y337

680680

expression in Pichia pastoris

Homo sapiens

-

669319

gene KLK5, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4

Homo sapiens

Q9Y337

647332

gene KLK5, located at the chromosomal locus 19q13.3-q13.4, quantitative real-time PCR expression analysis, 10 transcription factors as potential regulators were found on the control regions of both KLK5 and KLK7

Homo sapiens

-

707996

KLK5 quantitative real-time PCR expression analysis

Homo sapiens

Q9Y337

707624

overexpression in OV-MZ-6 cancer cell line inoculated into the peritoneal cavity of nude mice promotes tumor growth in mice

Homo sapiens

-

664273

recombinant KLK5 protein is generated from a recombinant baculovirus using the BAC-TO-BAC system (pFastBac_hKLK5_6His-Q-FLAG) expressed in 5L of Spodoptera frugiperda Super 9 insect cells

Homo sapiens

Q9Y337

753016