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Literature summary for 3.4.21.B39 extracted from

  • Yousef, G.M.; Diamandis, E.P.
    The new human tissue kallikrein gene family: structure, function, and association to disease (2001), Endocr. Rev., 22, 184-204.
    View publication on PubMed
Search for more literature for 3.4.21.B39

Activating Compound

Activating Compound Comment Organism Structure
androgens slight up-regulation Homo sapiens
estrogen up-regulaion Homo sapiens
progestins up-regulaion Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene KLK5, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involved in ovarian cancer ?
-
 ?
additional information Homo sapiens regulation by steroid homones ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y337 gene KLK5 or SCTE
-
Homo sapiens Q9Y337 gene KLK5
-

Reaction

Reaction Comment Organism Reaction ID
proteolytic cleavage of polypeptides substrate binding pocket contains an Asp residue Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
brain high expression level Homo sapiens
-
breast high expression level Homo sapiens
-
ovarian carcinoma cell gene overexpression in a subset of more aggressive ovarian tumors Homo sapiens
-
prostate
-
 Homo sapiens
-
salivary gland
-
 Homo sapiens
-
skin high expression level Homo sapiens
-
testis high expression level Homo sapiens
-
thymus
-
 Homo sapiens
-
thyroid gland
-
 Homo sapiens
-
trachea
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involved in ovarian cancer Homo sapiens ?
-
 ?
additional information regulation by steroid homones Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
K5
-
 Homo sapiens
SCTE
-
 Homo sapiens