Cloned (Comment) | Organism |
---|---|
expressed in a baculovirus-insect cell system | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystallized in complex with leupeptin, sitting drop vapour diffusion method with 0.2 M ammonium sulfate, 0.1 M Mes (pH 5.6) and 30% (w/v) PEG monomethyl ether 500 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
leupeptin | - |
Homo sapiens | |
Zn2+ | non-competitive inhibition, the enzyme activity is restored by addition of EDTA showing reversibility | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y337 | - |
- |
Purification (Comment) | Organism |
---|---|
heparin-Sepharose column chromatography and benzamidine-Sepharose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cbz-L-Pro-Phe-Arg-p-nitroanilide + H2O | - |
Homo sapiens | Cbz-L-Pro-Phe-Arg + 4-nitroaniline | - |
? | |
L-Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | L-Pro-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | tosyl-Gly-Pro-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
K5 | - |
Homo sapiens |
kallikrein-like protein 2 | - |
Homo sapiens |
KLK-L2 | - |
Homo sapiens |
tissue kallikrein 5 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0017 | - |
leupeptin | at 25°C in 0.2 M NaCl, 0.1 M Tris-HCl (pH 8.0), and 9% (w/v) Me2SO | Homo sapiens | |
0.002 | - |
Zn2+ | in 150 mM NaCl, 20 mM HEPES, 0.04 mM imidazole, 0.005% (v/v) Tween 20, at pH 8.0 | Homo sapiens | |
0.008 | - |
Zn2+ | in 150 mM NaCl, 20 mM HEPES, 0.04 mM imidazole, 0.005% (v/v) Tween 20, at pH 7.0 | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.009 | - |
in 150 mM NaCl, 20 mM HEPES, 0.04 mM imidazole, 0.005% (v/v) Tween 20, at pH 7.0 | Homo sapiens | Zn2+ |