3.4.21.B10: neurosin
This is an abbreviated version!
For detailed information about neurosin, go to the full flat file.
Word Map on EC 3.4.21.B10
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3.4.21.B10
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kallikreins
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trypsin-like
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medicine
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klk8
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par1
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diagnostics
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immunofluorometric
- 3.4.21.B10
- kallikreins
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trypsin-like
- medicine
- klk8
- par1
- diagnostics
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immunofluorometric
Reaction
proteolytic cleavage of polypeptides =
Synonyms
GK, hK6, KAL-B, kallikrein 6, kallikrein-6, kallikrein-related peptidase, kallikrein-related peptidase 6, KLK6, KRP/hK6, myelencephalonspecific protease, neurosin, protease M, S01.236, serine protease 18, serine protease 9, SP59, tissue kallikrein 6, zyme
ECTree
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Source Tissue on EC 3.4.21.B10 - neurosin
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
breast carcinoma cell line, enzyme is up-regulated by estrogens, progestin and slightly by androgen
quantitative real-time PCR enzyme expression analysis
quantitative real-time PCR enzyme expression analysis
73 intracranial tumor samples are screened for enzyme expression by quantitative real-time PCR analysis, overview
splice variant 3 is preferentially expressed in spinal cord, mammary, and salivary glands and to lesser extent in protstate
MCF-7 cells with low metastatic potential express KLK6 mRNA and protein levels comparable to normal human mammary epithelial cells
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under resting conditions, Neu 7 astrocytes exhibit a high basal level of stellation, protease activated receptors PAR1 and PAR2 cause a significant reversal of astrocyte stellation
splice variant 3 is preferentially expressed in spinal cord, mammary, and salivary glands and to lesser extent in protstate
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expression of hK6 is downregulated in comparison with normal salivary gland tissue
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strong expression in stromal cells located adjacent to benign nevi, primary melanomas, and cutaneous metastatic lesions
additional information
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predominantly expressed in brain. Located not only in the activated microglia cells but also in amyloid plaque and neurofilament tangles in Alzheimer fluid
highly down-regulated at metastatic breast cancer sites
highly expressed in the central nervous system and with elevated level in demyelinating disease
in synucleinopathies, including Parkinson disease, the levels of KLK6 inversely correlate with alpha-synuclein in cerebrospinal fluid
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strong expression in keratinocytes located adjacent to benign nevi, primary melanomas, and cutaneous metastatic lesions
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altered morphology (spindle like cell morphology) and proliferation of keratinocytes with ectopic Klk6 expression. Klk6 expression induces keratinocyte migration and invasion
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primary cerebellar granule neuron and NSC34 spinal cord motoneuron cell culture
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primary cerebellar granule neuron and NSC34 spinal cord motoneuron cell culture
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gene amplification is one mechanism for the overexpression of hK6 in ovarian cancer. High expression of hK6 protein in coexisting benign, borderline and invasive ovarian tumours is observed. The tumours also express high levels of kallikrein 6 mRNA
KLK6 is upregulated. In benign tumour tissue, KLK6 expression is low
splice variant 3 is preferentially expressed in spinal cord, mammary, and salivary glands and to lesser extent in protstate
weakly expressed in the epidermis of normal skin, restricted to keratinocytes of the suprabasal epidermis and hair follicles
splice variant 3 is preferentially expressed in spinal cord, mammary, and salivary glands and to lesser extent in protstate
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Klk6 expression is elevated in the spinal cord of mice with experimental autoimmune encephalomyelitis at the peak of clinical disease
additional information
the KLK6 gene encodes for various isoforms produced by the utilization of intronic sequences and alternative promoters with multiple transcriptional start sites (transcript variants) or by splicing out coding exons (splice variants). Transcripts encoding full-length hK6 protein are the predominant mRNA species in normal and tumor cells. KLK6 transcript variants 1, 2 and 3, all encode for full-length hK6 protein
additional information
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the KLK6 gene encodes for various isoforms produced by the utilization of intronic sequences and alternative promoters with multiple transcriptional start sites (transcript variants) or by splicing out coding exons (splice variants). Transcripts encoding full-length hK6 protein are the predominant mRNA species in normal and tumor cells. KLK6 transcript variants 1, 2 and 3, all encode for full-length hK6 protein
additional information
21PT cell isolated from a primary breast tumor, highly overexpresses KLK6. KLK6 expression is absent or very low in metastatic breast cancer cell lines MDA-MB-231, BT-474, MDA-MB-435, MDAMB-435P, ZR-75-1 and T47D
additional information
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21PT cell isolated from a primary breast tumor, highly overexpresses KLK6. KLK6 expression is absent or very low in metastatic breast cancer cell lines MDA-MB-231, BT-474, MDA-MB-435, MDAMB-435P, ZR-75-1 and T47D
additional information
KLK6 is upregulated in vulva cancer cells and malignant melanomas
additional information
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KLK6 is upregulated in vulva cancer cells and malignant melanomas
additional information
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KRP/hK6 is present in lung small cell carcinoma and carcinoid tumour cell. Absent from lung adenocarcinoma
additional information
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ovarian cancer ascites fluid from ovarian cancer patients during therapeutic drainage. hK6 and hK10 concentrations are positively correlated in ovarian cancer ascites fluid, majority of hK6 present in the free (uncomplexed) form
additional information
inactivated expression in metastatic breast cancer
additional information
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KLK6 is not detectable in tumor cells of primary and metastatic melanoma and is specifically absent in atypic melanocytes of dysplastic nevi
additional information
enzyme expression analysis in gastric cancer and cell lines, overview. No or poor expression in Jurkat and HS677.st cells
additional information
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enzyme expression analysis in gastric cancer and cell lines, overview. No or poor expression in Jurkat and HS677.st cells
additional information
immunohistochemic enzyme tissue expression analysis, overview
additional information
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immunohistochemic enzyme tissue expression analysis, overview
additional information
significantly increased enzyme expression in early invasive cancer compared with dysplastic and nondysplastic Barrett esophagus, immunohistochemic analysis, overview
additional information
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significantly increased enzyme expression in early invasive cancer compared with dysplastic and nondysplastic Barrett esophagus, immunohistochemic analysis, overview
additional information
the enzyme is expressed more frequently in tumors of high malignancy, like the glioblastomas, and less in tumors of low malignancy, like the meningiomas. No expression in cell lines U-251-MG and D-54
additional information
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the enzyme is expressed more frequently in tumors of high malignancy, like the glioblastomas, and less in tumors of low malignancy, like the meningiomas. No expression in cell lines U-251-MG and D-54
additional information
the level of enzyme is significantly increased in the plasma samples from the cancer cohort compared to the benign and healthy cohorts and shows a slight decrease in the postoperative plasma samples in comparison to the preoperative plasma samples, overview
additional information
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the level of enzyme is significantly increased in the plasma samples from the cancer cohort compared to the benign and healthy cohorts and shows a slight decrease in the postoperative plasma samples in comparison to the preoperative plasma samples, overview
additional information
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in SJL mice infected with Theiler's murine encephalomyelitis virus, enzyme expression persisted primarily in the spinal cord reaching a peak of fivefold over controls at mid-chronic stages, expression of Klk6 RNA is differentially regulated in the brain and spinal cord across the acute, subacute and more chronic phases, overview
additional information
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quantitative PCR-based enzyme expression analysis in spinal cord injury, overview
additional information
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quantitative PCR-based enzyme expression analysis in spinal cord injury, overview
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additional information
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in SJL mice infected with Theiler's murine encephalomyelitis virus, enzyme expression persisted primarily in the spinal cord reaching a peak of fivefold over controls at mid-chronic stages, expression of Klk6 RNA is differentially regulated in the brain and spinal cord across the acute, subacute and more chronic phases, overview
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