3.4.21.B10: neurosin
This is an abbreviated version!
For detailed information about neurosin, go to the full flat file.
Word Map on EC 3.4.21.B10
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3.4.21.B10
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kallikreins
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trypsin-like
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medicine
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klk8
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par1
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diagnostics
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immunofluorometric
- 3.4.21.B10
- kallikreins
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trypsin-like
- medicine
- klk8
- par1
- diagnostics
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immunofluorometric
Reaction
proteolytic cleavage of polypeptides =
Synonyms
GK, hK6, KAL-B, kallikrein 6, kallikrein-6, kallikrein-related peptidase, kallikrein-related peptidase 6, KLK6, KRP/hK6, myelencephalonspecific protease, neurosin, protease M, S01.236, serine protease 18, serine protease 9, SP59, tissue kallikrein 6, zyme
ECTree
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Localization
Localization on EC 3.4.21.B10 - neurosin
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heterologous expression of pre-pro-neurosin is localized to the endoplasmic reticulum, intracellular neurosin has no protease activity
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KLK6 localizes to caveolin-1-containing membrane fractions in the presence, but not the absence of caveolin-1
additional information
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KRP/hK6 is cytoplasmic in brain, lung and submandibular gland and is present in the cytoplasm of squamous cell carcinoma, small cell carcinoma and carcinoid tumour. Absent from cytoplasm of tumour cells of adenocarcinoma
KLK6 expression in ovarian tumour cytosols is 57fold higher than in normal tissue and 31fold higher than in begnin and nonovarian metastatic tumours
the enzyme expression shows a granular cytoplasmic pattern of staining with luminal accentuation, immunohistochemic analysis, overview
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additional information
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the enzyme expression shows a granular cytoplasmic pattern of staining with luminal accentuation, immunohistochemic analysis, overview
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