3.4.21.B10: neurosin

This is an abbreviated version!
For detailed information about neurosin, go to the full flat file.

Word Map on EC 3.4.21.B10

3.4.21.B10

kallikreins

trypsin-like

medicine

klk8

par1

diagnostics

immunofluorometric

Reaction

proteolytic cleavage of polypeptides =

Synonyms

GK, hK6, KAL-B, kallikrein 6, kallikrein-6, kallikrein-related peptidase, kallikrein-related peptidase 6, KLK6, KRP/hK6, myelencephalonspecific protease, neurosin, protease M, S01.236, serine protease 18, serine protease 9, SP59, tissue kallikrein 6, zyme

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B10 neurosin

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Results	in table
16	Activating Compound
4	AA Sequence
22	Application
2	CAS Registry Number
31	Cloned(Commentary)
4	Crystallization (Commentary)
569	Disease/ Diagnostics
9	Expression
26	General Information
11	IC50 Value
46	Inhibitors
22	kcat/KM [mM/s]
3	Ki Value [mM]
41	KM Value [mM]
11	Localization
1	Metals/Ions
7	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
177	Organism
2	pH Range
8	Posttranslational Modification
6	Protein Variants
8	Purification (Commentary)
2	Reaction
1	Reaction Type
62	Reference
1	Renatured (Commentary)
153	Source Tissue
99	Substrates and Products (Substrate)
3	Subunits
118	Synonyms
40	Turnover Number [1/s]

Expression

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Expression on EC 3.4.21.B10 - neurosin

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highly up-regulated in several types of cancer, where its increased activity promotes cancer invasion and metastasis

Homo sapiens

Q92876

754166

injury-induced elevations in enzyme level

Mus musculus

731396

Klk6 RNA is up-regulated in splenocytes in a viral capsid protein dependent fashion, using recombinnatly expressed encoding Theiler's murine encephalomyelitis virus TMEV VP1 and VP2 capsid proteins, and in THP-1 monocytes activated by phorbol 12-myristate-13-acetate and lipopolysaccharide

Homo sapiens

Q92876

731563

no change in KLK6 expression is observed upon treatment of T47D cells with trichostatin A

Homo sapiens

Q92876

707981

SJL mice infecteion with Theiler's murine encephalomyelitis virus causes an increase in enzyme expression in the spinal cord and in splenocytes. Klk6 RNA is up-regulated in splenocytes in a viral capsid protein dependent fashion, using recombinnatly expressed encodingTMEVVP1 andVP2 capsid proteins, and in THP-1 monocytes activated by phorbol 12-myristate-13-acetate and lipopolysaccharide

2 entries

stepwise expression increase from metaplasia to dysplasia and invasive tumors, significantly increased enzyme expression in early invasive cancer, overview

Homo sapiens

Q92876

731898

the enzyme is up-regulated in ovarian cancer

Homo sapiens

Q92876

731397

treatment of MDA-MB-231 and T47D breast tumor cell lines with 5-aza-2'-deoxycytidine results in significant induction of KLK6 expression

Homo sapiens

Q92876

707981