3.4.21.B10: neurosin

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For detailed information about neurosin, go to the full flat file.

Word Map on EC 3.4.21.B10

3.4.21.B10

kallikreins

trypsin-like

medicine

klk8

par1

diagnostics

immunofluorometric

Reaction

proteolytic cleavage of polypeptides =

Synonyms

GK, hK6, KAL-B, kallikrein 6, kallikrein-6, kallikrein-related peptidase, kallikrein-related peptidase 6, KLK6, KRP/hK6, myelencephalonspecific protease, neurosin, protease M, S01.236, serine protease 18, serine protease 9, SP59, tissue kallikrein 6, zyme

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B10 neurosin

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Results	in table
16	Activating Compound
4	AA Sequence
22	Application
2	CAS Registry Number
31	Cloned(Commentary)
4	Crystallization (Commentary)
569	Disease/ Diagnostics
9	Expression
26	General Information
11	IC50 Value
46	Inhibitors
22	kcat/KM [mM/s]
3	Ki Value [mM]
41	KM Value [mM]
11	Localization
1	Metals/Ions
7	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
177	Organism
2	pH Range
8	Posttranslational Modification
6	Protein Variants
8	Purification (Commentary)
2	Reaction
1	Reaction Type
62	Reference
1	Renatured (Commentary)
153	Source Tissue
99	Substrates and Products (Substrate)
3	Subunits
118	Synonyms
40	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.21.B10 - neurosin

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2 entries

crystal structures of the APPIWT/KLK6 and APPI-4M/KLK6 complexes reveal the structural and mechanistic bases for the improved KLK6 binding and proteolytic resistance of APPI-4M. APPI is the amyloid precursor protein Kunitz protease inhibitor domain. APPI-4M i.e. APPI(M17L/I18F/S19F/F34V)

Homo sapiens

Q92876

754166

purified enzyme bound to inhibitor 9b, X-ray diffraction structure determination and analysis at 1.68 A resolution

Homo sapiens

Q92876

731428