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Literature summary for 3.4.21.B10 extracted from

  • Tatebe, H.; Watanabe, Y.; Kasai, T.; Mizuno, T.; Nakagawa, M.; Tanaka, M.; Tokuda, T.
    Extracellular neurosin degrades alpha-synuclein in cultured cells (2010), Neurosci. Res., 67, 341-346.
    View publication on PubMed
Search for more literature for 3.4.21.B10

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum heterologous expression of pre-pro-neurosin is localized to the endoplasmic reticulum, intracellular neurosin has no protease activity Homo sapiens 5783
-
extracellular extracellular neurosin has protease activity Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
 calculated from amino acid sequence Homo sapiens
32000
-
 SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system predominantly expressed in the central nervous system Homo sapiens
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-synuclein + H2O neurosin may degrade alpha-synuclein, a major component of the Lewy bodies commonly observed in dopaminergic neurons of patients with sporadic Parkinson’s disease Homo sapiens ?
-
 ?
benzyloxycarbonyl-L-Gln-L-Ala-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Gln-L-Ala-L-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein 6
-
 Homo sapiens