Literature summary for 3.4.21.B10 extracted from

Kim, J.J.; Kim, J.T.; Yoon, H.R.; Kang, M.A.; Kim, J.H.; Lee, Y.H.; Kim, J.W.; Lee, S.J.; Song, E.Y.; Myung, P.K.; Lee, H.G.
Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer (2012), Tumour Biol., 33, 731-738.

Search for more literature for 3.4.21.B10

Application

Application	Comment	Organism
diagnostics	the enzyme might be used as a potential biomarker and therapeutic target for gastric cancer	Homo sapiens
medicine	the enzyme might be used as a potential biomarker and therapeutic target for gastric cancer	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene KLK6 encoding kallikrein-related peptidase 6 is located within the kallikrein gene cluster containing 15 kallikrein genes that share homology at the DNA-amino acid level and five pseudogenes on chromosome 19q13	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme gene silencing by KLK6-siRNA	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	secretion of the enzyme from gastric cancer cells	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92876	gene KLK6	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
AGS cell	low enzyme expression	Homo sapiens	-
gastric cancer cell	high enzyme upregulation	Homo sapiens	-
additional information	enzyme expression analysis in gastric cancer and cell lines, overview. No or poor expression in Jurkat and HS677.st cells	Homo sapiens	-
SNU-1 cell	very low enzyme expression	Homo sapiens	-
SNU-16 cell	-	Homo sapiens	-
SNU-216 cell	-	Homo sapiens	-
SNU-620 cell	-	Homo sapiens	-
SNU-638 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
kallikrein-related peptidase 6	-	Homo sapiens
KLK6	-	Homo sapiens

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Release 2023.1 (January 2023)