3.4.21.B10: neurosin
This is an abbreviated version!
For detailed information about neurosin, go to the full flat file.
Word Map on EC 3.4.21.B10
-
3.4.21.B10
-
kallikreins
-
trypsin-like
-
medicine
-
klk8
-
par1
-
diagnostics
-
immunofluorometric
- 3.4.21.B10
- kallikreins
-
trypsin-like
- medicine
- klk8
- par1
- diagnostics
-
immunofluorometric
Reaction
proteolytic cleavage of polypeptides =
Synonyms
GK, hK6, KAL-B, kallikrein 6, kallikrein-6, kallikrein-related peptidase, kallikrein-related peptidase 6, KLK6, KRP/hK6, myelencephalonspecific protease, neurosin, protease M, S01.236, serine protease 18, serine protease 9, SP59, tissue kallikrein 6, zyme
ECTree
3.4.21.B10 neurosinAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 3.4.21.B10 - neurosin
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2'-deoxy-5-azacytidine
can reactivate KLK6 in non-expressing breast cancer cells. Induces KLK6 expression in cell lines MDA-MB-435P, BT-474, MCF-7, and ZR-75-1 and significantly increases synthesis of hK6 protein. Results in a 2fold increase in KLK6 mRNA and protein levels in HMECs. Combined 5-aza-29-deoxycytidine/trichostatin A treatment results in synergistic activation of KLK6 in MDA-MB-231 cells
EB1089
vitamin D3 analog EB1089 can restore KLK6 expression in T47D cells
trichostatin A
moderately induces KLK6 in MDA-MB-231 cells. Combined 5-aza-29-deoxycytidine/trichostatin A treatment results in synergistic activation of KLK6 in MDA-MB-231 cells
additional information
-
self-regulating activity of KLK6 is negative feedback inhibition via autolytic inactivation. Activation of pro-KLK6 may be achieved through the action of a separate activating protease (possibly plasmin or KLK5)
-
additional information
the steroid hormones estradiol, aldosterone, dihydrotestosterone, dexamethasone and norgestrol do not significantly change KLK6 expression in ovarian cancer cell lines
-
additional information
-
the steroid hormones estradiol, aldosterone, dihydrotestosterone, dexamethasone and norgestrol do not significantly change KLK6 expression in ovarian cancer cell lines
-
additional information
-
expression of protease M is increased in GST-pi-positive oligodendrocytes during remyelination. After tumor necrosis factor-alpha and IFN-gamma stimulation colocalization of protease M and myelin basic protein in the oligodendroglial process
-
