Literature summary for 3.4.21.B10 extracted from

Grin, A.; Samaan, S.; Tripathi, M.; Rotondo, F.; Kovacs, K.; Bassily, M.N.; Yousef, G.M.
Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma (2015), Hum. Pathol., 46, 541-548.

Search for more literature for 3.4.21.B10

Application

Application	Comment	Organism
diagnostics	enzyme KLK6 is significantly associated with other prognostic markers in gastroesophageal junction adenocarcinoma and Barrett esophagus, including depth of invasion, indicating its potential as independent biomarker	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	the enzyme expression shows a granular cytoplasmic pattern of staining with luminal accentuation, immunohistochemic analysis, overview	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92876	gene KLK6	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
esophagus	Barrett esophagus with and without dysplasia	Homo sapiens	-
gastroesophageal junction adenocarcinoma cell	early stage	Homo sapiens	-
additional information	significantly increased enzyme expression in early invasive cancer compared with dysplastic and nondysplastic Barrett esophagus, immunohistochemic analysis, overview	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
kallikrein-related peptidase 6	-	Homo sapiens
KLK6	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	stepwise expression increase from metaplasia to dysplasia and invasive tumors, significantly increased enzyme expression in early invasive cancer, overview	up

General Information

General Information	Comment	Organism
evolution	the enzyme is a member of the human kallikrein gene family of secreted serine proteases	Homo sapiens
additional information	significant correlation between KLK6 and KLK10 expression both at the invasive front and within the main tumor, indicating a collaborative effect	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)