Literature summary for 3.4.21.B10 extracted from

Shan, S.J.; Scorilas, A.; Katsaros, D.; Diamandis, E.P.
Transcriptional upregulation of human tissue kallikrein 6 in ovarian cancer: clinical and mechanistic aspects (2007), Br. J. Cancer, 96, 362-372.

Search for more literature for 3.4.21.B10

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the steroid hormones estradiol, aldosterone, dihydrotestosterone, dexamethasone and norgestrol do not significantly change KLK6 expression in ovarian cancer cell lines	Homo sapiens

Application

Application	Comment	Organism
medicine	KLK6 is an unfavorable prognostic biomarker for ovarian cancer. KLK6 is transcriptionally upregulated in ovarian cancer, but probably not through alternative mRNA transcript expression, genomic mutation, or steroid hormone induction. Upregulation correlates with cancer stage	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	KLK6 expression in ovarian tumour cytosols is 57fold higher than in normal tissue and 31fold higher than in begnin and nonovarian metastatic tumours	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92876	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BG-1 cell	-	Homo sapiens	-
CAOV-3 cell	-	Homo sapiens	-
ovary	low KLK6 expression	Homo sapiens	-
ovary cancer cell	KLK6 is upregulated. In benign tumour tissue, KLK6 expression is low	Homo sapiens	-
OVCAR-3 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
kallikrein 6	-	Homo sapiens
KLK6	-	Homo sapiens

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Release 2023.1 (January 2023)