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Literature summary for 3.4.21.B10 extracted from

  • Yoon, H.; Radulovic, M.; Wu, J.; Blaber, S.I.; Blaber, M.; Fehlings, M.G.; Scarisbrick, I.A.
    Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity (2013), J. Neurochem., 127, 283-298.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B10

Cloned(Commentary)

Cloned (Comment) Organism
quantitative PCR-based enzyme expression analysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proform protease activated receptor 1 + H2O Mus musculus
-
 mature protease activated receptor 1 + ?
-
 ?
proform protease activated receptor 1 + H2O Mus musculus C57/BL6J
-
 mature protease activated receptor 1 + ?
-
 ?
proform protease activated receptor 2 + H2O Mus musculus
-
 mature protease activated receptor 2 + ?
-
 ?
proform protease activated receptor 2 + H2O Mus musculus C57/BL6J
-
 mature protease activated receptor 2 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57/BL6J
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information quantitative PCR-based enzyme expression analysis in spinal cord injury, overview Mus musculus
-
neuron primary cerebellar granule neuron and NSC34 spinal cord motoneuron cell culture Mus musculus
-
NSC-34 cell
-
 Mus musculus
-
spinal cord
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proform protease activated receptor 1 + H2O
-
 Mus musculus mature protease activated receptor 1 + ?
-
 ?
proform protease activated receptor 1 + H2O
-
 Mus musculus C57/BL6J mature protease activated receptor 1 + ?
-
 ?
proform protease activated receptor 2 + H2O
-
 Mus musculus mature protease activated receptor 2 + ?
-
 ?
proform protease activated receptor 2 + H2O
-
 Mus musculus C57/BL6J mature protease activated receptor 2 + ?
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein 6
-
 Mus musculus
KLK6
-
 Mus musculus

General Information

General Information Comment Organism
malfunction ERK1/2 signaling in cerebellar granule neurons and in the NSC34 spinal cord motoneuron cell line is reduced by lipopeptide inhibitors of PAR1 or PAR2, and PAR1 genetic deletion, which reduces the neurotoxic effects of the enzyme Mus musculus
metabolism kallikrein 6 and thrombin are important regulators of neural pathophysiology and neurotoxic Mus musculus
additional information Klk6 and the prototypical activator of protease activated receptor 1, PAR1, thrombin, as well as PAR1 and PAR2, are each elevated in murine experimental traumatic spinal cord injury at acute or subacute time points Mus musculus
physiological function kallikrein 6 is a serine protease implicated in neurodegeneration. Kallikrein 6 elicits ERK1/2 signaling in neurons by activation of protease activated receptors PAR1 and PAR2. Recombinant Klk6 triggered ERK1/2 signaling in cerebellar granule neurons and in the NSC34 spinal cord motoneuron cell line, in a PI3K and MEK-dependent fashion. Kallikrein 6 and thrombin promote degeneration of cerebellar neurons and exacerbate glutamate neurotoxicity Mus musculus