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Literature summary for 3.4.21.B10 extracted from

  • Klucky, B.; Mueller, R.; Vogt, I.; Teurich, S.; Hartenstein, B.; Breuhahn, K.; Flechtenmacher, C.; Angel, P.; Hess, J.
    Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion (2007), Cancer Res., 67, 8198-8206.
    View publication on PubMed

Application

Application Comment Organism
medicine Klk6 expression decreases E-cadherin levels at the membrane in concert with cytoplasmic and nuclear accumulation of beta-catenin. Klk6 transgene expression induces keratinocyte proliferation and migration during cutaneous wound healing Mus musculus
medicine KLK6 is a biomarker for tumor diagnosis and management and a promising therapeutic target. KLK6 expression induces E-cadherin ectodomain shedding and reduces cell-cell adhesion. KLK6-induced E-cadherin ectodomain shedding requires proteolytic activity of matrix metalloproteinase and/or disintegrin and metalloproteinase Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
pcDNA3.1-KLK6-Myc/His vector expressed in HEK-293 cells Homo sapiens
pcDNA3.1-Klk6-Myc/His-tagged fusion protein expressed in the mouse keratinocyte cell line MCA3D Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92876
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Mus musculus
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Purification (Commentary)

Purification (Comment) Organism
by metal affinity resin Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
gastric cancer cell KLK6 is upregulated Homo sapiens
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keratinocyte
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Homo sapiens
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keratinocyte altered morphology (spindle like cell morphology) and proliferation of keratinocytes with ectopic Klk6 expression. Klk6 expression induces keratinocyte migration and invasion Mus musculus
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additional information KLK6 is upregulated in vulva cancer cells and malignant melanomas Homo sapiens
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ovary cancer cell KLK6 is upregulated Homo sapiens
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skin weakly expressed in the epidermis of normal skin, restricted to keratinocytes of the suprabasal epidermis and hair follicles Homo sapiens
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squamous cell carcinoma cell KLK6 is upregulated Homo sapiens
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Synonyms

Synonyms Comment Organism
kallikrein 6
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Mus musculus
kallikrein 6
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Homo sapiens
KLK6
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Mus musculus
KLK6
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Homo sapiens