Application | Comment | Organism |
---|---|---|
medicine | Klk6 expression decreases E-cadherin levels at the membrane in concert with cytoplasmic and nuclear accumulation of beta-catenin. Klk6 transgene expression induces keratinocyte proliferation and migration during cutaneous wound healing | Mus musculus |
medicine | KLK6 is a biomarker for tumor diagnosis and management and a promising therapeutic target. KLK6 expression induces E-cadherin ectodomain shedding and reduces cell-cell adhesion. KLK6-induced E-cadherin ectodomain shedding requires proteolytic activity of matrix metalloproteinase and/or disintegrin and metalloproteinase | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
pcDNA3.1-KLK6-Myc/His vector expressed in HEK-293 cells | Homo sapiens |
pcDNA3.1-Klk6-Myc/His-tagged fusion protein expressed in the mouse keratinocyte cell line MCA3D | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92876 | - |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by metal affinity resin | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric cancer cell | KLK6 is upregulated | Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
keratinocyte | altered morphology (spindle like cell morphology) and proliferation of keratinocytes with ectopic Klk6 expression. Klk6 expression induces keratinocyte migration and invasion | Mus musculus | - |
additional information | KLK6 is upregulated in vulva cancer cells and malignant melanomas | Homo sapiens | - |
ovary cancer cell | KLK6 is upregulated | Homo sapiens | - |
skin | weakly expressed in the epidermis of normal skin, restricted to keratinocytes of the suprabasal epidermis and hair follicles | Homo sapiens | - |
squamous cell carcinoma cell | KLK6 is upregulated | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
kallikrein 6 | - |
Mus musculus |
kallikrein 6 | - |
Homo sapiens |
KLK6 | - |
Mus musculus |
KLK6 | - |
Homo sapiens |