Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.B10 extracted from

  • Yousef, G.M.; Diamandis, E.P.
    The new human tissue kallikrein gene family: structure, function, and association to disease (2001), Endocr. Rev., 22, 184-204.
    View publication on PubMed
Search for more literature for 3.4.21.B10

Activating Compound

Activating Compound Comment Organism Structure
androgens slight up-regulation Homo sapiens
estrogen up-regulaion Homo sapiens
progestins up-regulaion Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene KLK6, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor proteins + H2O Homo sapiens enzyme may play a role in development of Alzheimer's disease ?
-
 ?
additional information Homo sapiens enzyme is involved in breast and ovarian cancer ?
-
 ?
additional information Homo sapiens regulation by steroid hormones ?
-
 ?
polypeptide + H2O Homo sapiens
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92876 gene KLK6
-

Reaction

Reaction Comment Organism Reaction ID
proteolytic cleavage of polypeptides substrate binding pocket contains an Asp residue Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
breast high expression level Homo sapiens
-
breast carcinoma cell up-regulated in primary tumors Homo sapiens
-
breast carcinoma cell highly down-regulated at metastatic breast cancer sites Homo sapiens
-
BT-474 cell breast carcinoma cell line, enzyme is up-regulated by estrogens, progestin and slightly by androgen Homo sapiens
-
central nervous system high expression level Homo sapiens
-
kidney high expression level Homo sapiens
-
ovarian carcinoma cell up-regulated in primary tumors Homo sapiens
-
ovary
-
 Homo sapiens
-
salivary gland
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-
testis
-
 Homo sapiens
-
uterus high expression level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor proteins + H2O
-
 Homo sapiens ?
-
 ?
amyloid precursor proteins + H2O enzyme may play a role in development of Alzheimer's disease Homo sapiens ?
-
 ?
additional information enzyme is involved in breast and ovarian cancer Homo sapiens ?
-
 ?
additional information regulation by steroid hormones Homo sapiens ?
-
 ?
polypeptide + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

Synonyms Comment Organism
protease M
-
 Homo sapiens