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Literature summary for 3.4.21.B10 extracted from

  • Scarisbrick, I.A.; Radulovic, M.; Burda, J.E.; Larson, N.; Blaber, S.I.; Giannini, C.; Blaber, M.; Vandell, A.G.
    Kallikrein 6 is a novel molecular trigger of reactive astrogliosis (2012), Biol. Chem., 393, 355-367.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B10

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin pan-serine protease inhibitor Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme activates G-protein coupled protease activated receptors ?
-
 ?
proform protease activated receptor 1 + H2O Mus musculus
-
 mature protease activated receptor 1 + ?
-
 ?
proform protease activated receptor 2 + H2O Mus musculus
-
 mature protease activated receptor 2 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte primary cell culture Mus musculus
-
central nervous system
-
 Mus musculus
-
Neu-7 cell under resting conditions, Neu 7 astrocytes exhibit a high basal level of stellation, protease activated receptors PAR1 and PAR2 cause a significant reversal of astrocyte stellation Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme activates G-protein coupled protease activated receptors Mus musculus ?
-
 ?
proform protease activated receptor 1 + H2O
-
 Mus musculus mature protease activated receptor 1 + ?
-
 ?
proform protease activated receptor 2 + H2O
-
 Mus musculus mature protease activated receptor 2 + ?
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein 6
-
 Mus musculus
kallikrein-related peptidase 6
-
 Mus musculus
KLK6
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus injury-induced elevations in enzyme level up

General Information

General Information Comment Organism
physiological function the enzyme activates G-protein coupled protease activated receptors. The enzyme serves as a molecular trigger of selected physiological processes involved in the development of astrogliosis and causes astrocytes to transform from an epitheliod to a stellate morphology and to secrete interleukin 6. It reduces expression of glial fibrillary acidic protein. Injury-induced elevations in enzyme level contribute to the development of astrogliosis in a protease activated receptor-dependent fashion. The enzyme stellation promoting activity is dependent on activation of the thrombin receptor, PAR1, the enzyme effects are blocked by the PAR1 specific inhibitor SCH79797. The kallikrein 6-induced astrocyte stellation is mediated by protein kinase C. Kallikrein 6 activates PAR1 in neurons and PAR1 and PAR2 in astrocytes to elicit intracellular Ca2+ flux and regulation of the mitogen activated protein kinase (MAPK) signaling pathway Mus musculus