Literature summary for 3.4.21.B10 extracted from

Pampalakis, G.; Prosnikli, E.; Agalioti, T.; Vlahou, A.; Zoumpourlis, V.; Sotiropoulou, G.
A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition (2009), Cancer Res., 69, 3779-3787.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92876	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	inactivated expression in metastatic breast cancer	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
kallikrein-related peptidase 6	-	Homo sapiens
KLK6	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	no change in KLK6 expression is observed upon treatment of T47D cells with trichostatin A	additional information
Homo sapiens	treatment of MDA-MB-231 and T47D breast tumor cell lines with 5-aza-2'-deoxycytidine results in significant induction of KLK6 expression	up

General Information

General Information	Comment	Organism
physiological function	KLK6 is an epigenetically regulated tumor suppressor in human breast cancer. KLK6 re-expression in nonexpressing MDA-MB-231 breast tumor cells results in significant down-regulation of vimentin which represents an established marker of epithelial transition to mesenchymal transition of tumor cells and in concomitant upregulation of calreticulin and epithelial markers cytokeratin 8 and 19. Stable expression of KLK6 reduces proliferation rates, motility, and anchorage-independent growth of MDA-MB-231 cells	Homo sapiens

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Release 2023.1 (January 2023)