3.2.1.114: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
This is an abbreviated version!
For detailed information about mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, go to the full flat file.
Word Map on EC 3.2.1.114
-
3.2.1.114
-
swainsonine
-
n-linked
-
n-glycans
-
brefeldin
-
castanospermine
-
endoglycosidase
-
asparagine-linked
-
high-mannose
-
hybrid-type
-
complex-type
-
alpha-mannosidases
-
locoweed
-
indolizidine
-
1-deoxymannojirimycin
-
locoism
-
kifunensine
-
giantin
-
medicine
-
swainsonine-treated
-
man5glcnac
-
intra-golgi
-
1-deoxynojirimycin
-
oxytropis
-
high-mannose-type
-
beta-cop
-
mannostatins
-
glcnacman5glcnac2
-
biotechnology
-
drug development
-
pharmacology
- 3.2.1.114
- swainsonine
-
n-linked
- n-glycans
- brefeldin
- castanospermine
-
endoglycosidase
-
asparagine-linked
-
high-mannose
-
hybrid-type
-
complex-type
- alpha-mannosidases
-
locoweed
-
indolizidine
- 1-deoxymannojirimycin
-
locoism
- kifunensine
- giantin
- medicine
-
swainsonine-treated
- man5glcnac
-
intra-golgi
- 1-deoxynojirimycin
- oxytropis
-
high-mannose-type
- beta-cop
- mannostatins
- glcnacman5glcnac2
- biotechnology
- drug development
- pharmacology
Reaction
Synonyms
1,3(1,6)-alpha-D-mannosidase, 1,6-alpha-D-mannosidase, Afams1, alpha-1,3 mannosidase, alpha-1,3-mannosidase, alpha-D-mannosidase II, alpha-mannosidase, alpha-mannosidase II, alpha-mannosidase III, alpha-mannosidase IIx, alpha-MII, alpha1-3,6-mannosidase, Bt3991, class II alpha-D-mannosidase, class II alpha-mannosidase, class IIC alpha-mannosidase, dGMII, Drosophila GMII, exo-1,3-1,6-alpha-mannosidase, GH38 alpha-mannosidase II, GH38 enzyme, GH38 Golgi alpha-mannosidase II, GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase, glycoside hydrolase, GmII, Golgi alpha-mannosidase II, Golgi mannosidase IIx, human type II alpha-mannosidase, jack bean alpha-mannosidase, Man II, MAN IIx, MAN2A1, ManII, ManIII, mannose-trimming enzyme, mannosidase II, mannosidase, exo-1,3-1,6-alpha-, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase II, MII, More, NAM, neutral alpha-mannosidase, SpGH38, TM1851
ECTree
3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.2.1.114 - mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose + H2O
alpha-D-mannopyranose
-
-
-
-
?
Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-1-Asn + H2O
Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-1-Asn + alpha-D-mannose
physiological substrate, conversion by sequential removal of two alpha1,6-linked and alpha1,3-linked mannose residues from the alpha-1,6-branch of the substrate
-
-
?
Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O
Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
-
alpha-mannosidase IIx, M6Gn2 is the primary target in vivo, integral part of N-glycan biosynthesis
-
?
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O
Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
GlcNAc(Man)5GlcNAc + 2 H2O
GlcNAc(Man)3GlcNAc + 2 alpha-D-mannose
-
natural substrate, involved in the processing of N-linked oligosaccharides
-
?
GlcNAc(Man)5GlcNAc + 2 H2O
GlcNAc(Man)3GlcNAc + 2 alpha-D-mannose
-
natural substrate, involved in the processing of N-linked oligosaccharides
-
-
?
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O
Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
-
N-glycosylation pathway
-
?
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O
Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
-
alpha-mannosidase II, biosynthesis of N-glycans
-
?
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O
Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
-
involved in N-glycan maturation, acts after GlcNAc transferase I to remove 2 mannose residues to form GlcNAc(Man)3(GlcNAc)2 prior to extension into complex N-glycans
-
?
additional information
?
-
Golgi alpha-mannosidase II is a key enzyme in the formation of complex N-glycans in plants
-
-
?
additional information
?
-
-
Golgi alpha-mannosidase II is a key enzyme in the formation of complex N-glycans in plants
-
-
?
additional information
?
-
-
asparagine-linked glycoprotein biosynthesis
-
-
?
additional information
?
-
asparagine-linked glycoprotein biosynthesis
-
-
?
additional information
?
-
GMII is involved in the creation of glycoproteins that contain complex carbohydrates. It is responsible for the formation of the core trimannose structure to which all complex carbohydrates are appended. It catalyses the hydrolysis of an alpha(1,6)- and an alpha(1,3)-linked mannose from GlcNAc-Man5-GlcNAc2 to form GlcNAc-Man3-GlcNAc2-Asn-X
-
-
?
additional information
?
-
-
Co2+ regulates the substrate specificity, overview
-
-
?
additional information
?
-
-
Man II catalyzes the final hydrolytic step in the N-glycan maturation pathway acting as the committed step in the conversion of high mannose to complex type structures
-
-
?
additional information
?
-
-
involved in trimming reactions in N-glycan maturation in the Golgi complex
-
-
?
additional information
?
-
-
Bt1769, Bt3858 and Bt3991 are alpha-1,3-mannosidases that display particularly high activity against alpha-1,3-mannobiose
-
-
?
additional information
?
-
Man II catalyzes the final hydrolytic step in the N-glycan maturation pathway acting as the committed step in the conversion of high mannose to complex type structures
-
-
?
additional information
?
-
-
Man II catalyzes the final hydrolytic step in the N-glycan maturation pathway acting as the committed step in the conversion of high mannose to complex type structures
-
-
?
additional information
?
-
-
involved in trimming reactions in N-glycan maturation in the Golgi complex
-
-
?
additional information
?
-
-
MII and alpha-mannosidase IIx function in N-glycan processing in a similar manner
-
-
?
additional information
?
-
-
involved in asparagine-linked oligosaccharide processing
-
-
?
additional information
?
-
-
required in the maturation of asparagine-linked oligosaccharides in the Golgi complex
-
-
?
additional information
?
-
-
biosynthesis of complex-type N-linked oligosaccharides of glycoproteins
-
-
?
additional information
?
-
-
function in Golgi membranes: presumably glycopolymer metabolism
-
-
?
additional information
?
-
-
Man II catalyzes the final hydrolytic step in the N-glycan maturation pathway acting as the committed step in the conversion of high mannose to complex type structures
-
-
?
additional information
?
-
-
asparagine-linked glycoprotein biosynthesis
-
-
?
additional information
?
-
-
alpha-mannosidase III probably provides an alternate N-glycan processing pathway in Sf-9 cells
-
-
?
additional information
?
-
-
asparagine-linked glycoprotein biosynthesis
-
-
?
additional information
?
-
-
study of biosynthesis and processing of alpha-mannosidase III
-
-
?
additional information
?
-
higher eukaryotic GH38 alpha-mannosides play a key role in the modification and diversification of hybrid N-glycans, processes with strong cellular links to cancer and autoimmune disease
-
-
?
additional information
?
-
-
the exo-type cytosolic class II enzyme cleaves off alpha-1,2-, alpha-1,3-, and alpha-1,6-mannose residues
-
-
?
