3.2.1.114: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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For detailed information about mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, go to the full flat file.

Reaction

Synonyms

1,3(1,6)-alpha-D-mannosidase, 1,6-alpha-D-mannosidase, Afams1, alpha-1,3 mannosidase, alpha-1,3-mannosidase, alpha-D-mannosidase II, alpha-mannosidase, alpha-mannosidase II, alpha-mannosidase III, alpha-mannosidase IIx, alpha-MII, alpha1-3,6-mannosidase, Bt3991, class II alpha-D-mannosidase, class II alpha-mannosidase, class IIC alpha-mannosidase, dGMII, Drosophila GMII, exo-1,3-1,6-alpha-mannosidase, GH38 alpha-mannosidase II, GH38 enzyme, GH38 Golgi alpha-mannosidase II, GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase, glycoside hydrolase, GmII, Golgi alpha-mannosidase II, Golgi mannosidase IIx, human type II alpha-mannosidase, jack bean alpha-mannosidase, Man II, MAN IIx, MAN2A1, ManII, ManIII, mannose-trimming enzyme, mannosidase II, mannosidase, exo-1,3-1,6-alpha-, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase II, MII, More, NAM, neutral alpha-mannosidase, SpGH38, TM1851

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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Results	in table
12	Activating Compound
28	AA Sequence
11	Application
2	CAS Registry Number
18	Cloned(Commentary)
18	Crystallization (Commentary)
78	Disease/ Diagnostics
1	Expression
8	General Information
10	General Stability
43	IC50 Value
232	Inhibitors
6	kcat/KM [mM/s]
73	Ki Value [mM]
19	KM Value [mM]
70	Localization
71	Metals/Ions
37	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
96	Organism
5	Pathway
67	PDB ID
31	pH Optimum
8	pH Range
10	pH Stability
5	pI Value
21	Posttranslational Modification
14	Protein Variants
30	Purification (Commentary)
5	Reaction
6	Reaction Type
91	Reference
82	Source Tissue
16	Specific Activity [micromol/min/mg]
11	Storage Stability
219	Substrates and Products (Substrate)
30	Subunits
108	Synonyms
1	Systematic Name
37	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
7	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.2.1.114 - mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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SYSTEMATIC NAME

IUBMB Comments

(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase (configuration-retaining)

The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. It removes two mannosyl residues, one linked by alpha1,3 linkage, and the other linked by alpha1,6 linkage, both of which are removed by the same catalytic site. The enzyme is sensitive to swainsonine.