3.2.1.114: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

This is an abbreviated version!
For detailed information about mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, go to the full flat file.

Word Map on EC 3.2.1.114

3.2.1.114

swainsonine

n-linked

n-glycans

brefeldin

castanospermine

endoglycosidase

asparagine-linked

high-mannose

hybrid-type

complex-type

alpha-mannosidases

locoweed

indolizidine

1-deoxymannojirimycin

locoism

kifunensine

giantin

medicine

swainsonine-treated

man5glcnac

intra-golgi

1-deoxynojirimycin

oxytropis

high-mannose-type

beta-cop

mannostatins

glcnacman5glcnac2

biotechnology

drug development

pharmacology

Reaction

+ 2 H2O =

+ 2 alpha-D-mannopyranose

Synonyms

1,3(1,6)-alpha-D-mannosidase, 1,6-alpha-D-mannosidase, Afams1, alpha-1,3 mannosidase, alpha-1,3-mannosidase, alpha-D-mannosidase II, alpha-mannosidase, alpha-mannosidase II, alpha-mannosidase III, alpha-mannosidase IIx, alpha-MII, alpha1-3,6-mannosidase, Bt3991, class II alpha-D-mannosidase, class II alpha-mannosidase, class IIC alpha-mannosidase, dGMII, Drosophila GMII, exo-1,3-1,6-alpha-mannosidase, GH38 alpha-mannosidase II, GH38 enzyme, GH38 Golgi alpha-mannosidase II, GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase, glycoside hydrolase, GmII, Golgi alpha-mannosidase II, Golgi mannosidase IIx, human type II alpha-mannosidase, jack bean alpha-mannosidase, Man II, MAN IIx, MAN2A1, ManII, ManIII, mannose-trimming enzyme, mannosidase II, mannosidase, exo-1,3-1,6-alpha-, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase II, MII, More, NAM, neutral alpha-mannosidase, SpGH38, TM1851

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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Results	in table
12	Activating Compound
28	AA Sequence
11	Application
2	CAS Registry Number
18	Cloned(Commentary)
18	Crystallization (Commentary)
78	Disease/ Diagnostics
1	Expression
8	General Information
10	General Stability
43	IC50 Value
232	Inhibitors
6	kcat/KM [mM/s]
73	Ki Value [mM]
19	KM Value [mM]
70	Localization
71	Metals/Ions
37	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
96	Organism
5	Pathway
67	PDB ID
31	pH Optimum
8	pH Range
10	pH Stability
5	pI Value
21	Posttranslational Modification
14	Protein Variants
30	Purification (Commentary)
5	Reaction
6	Reaction Type
91	Reference
82	Source Tissue
16	Specific Activity [micromol/min/mg]
11	Storage Stability
219	Substrates and Products (Substrate)
30	Subunits
108	Synonyms
1	Systematic Name
37	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
7	Turnover Number [1/s]

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Application on EC 3.2.1.114 - mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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biotechnology

Homo sapiens

the Lec36 cell line will be useful for expressing therapeutic glycoproteins with hybrid-type glycans and as a sensitive host for detecting mutations in human MAN2A1 causing type II congenital dyserythropoietic anemia

drug development

medicine

pharmacology

the enzyme is a pharmaceutical target for the design of inhibitors with anti-cancer activity. The QSAR models with the fragmented QM-DFT descriptors may find a useful application in structure-based drug design where pure empirical and forcefield methods reach their limits and where quantum mechanics effects are critical for ligand-receptor interactions. The optimized models will apply in lead optimization processes for alpha-mannosidase II drug developments

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