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Literature summary for 3.2.1.114 extracted from
- Golgi alpha-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals (2002), Biochim. Biophys. Acta, 1573, 225-235.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme deficiency causes congenital dyserythropoietic anemia with splenomegaly and various additional abnormalities and complications | Mus musculus |
| medicine | enzyme deficiency causes congenital dyserythropoietic anemia with splenomegaly and various additional abnormalities and complications | Homo sapiens |
| medicine | reduced expression of Man II in the autosomal genetic HEMPAS disease, i.e. hereditary erythroblastic multinuclearity associated with positive acidified serum | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Golgi mannosidase II gene is located on chromosome 5q21, Golgi mannosidase IIx on chromosome 15q25 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mutants without GlcNAc(Man)5(GlcNAc)2 activity, Golgi mannosidase II-null mice phenotype | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,4-Dideoxy-1,4-imino-D-mannitol | - |
Homo sapiens |  |
| 1,4-Dideoxy-1,4-imino-D-mannitol | - |
Mus musculus | |
| 1,4-Dideoxy-1,4-imino-D-mannitol | - |
Rattus norvegicus | |
| swainsonine | - |
Drosophila melanogaster | |
| swainsonine | - |
Homo sapiens | |
| swainsonine | - |
Mus musculus | |
| swainsonine | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi apparatus | - |
Drosophila melanogaster | 5794 | - |
| Golgi apparatus | - |
Mus musculus | 5794 | - |
| Golgi apparatus | - |
Rattus norvegicus | 5794 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | - |
Rattus norvegicus | |
| Zn2+ | active site coordination to Zn2+ | Drosophila melanogaster | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Drosophila melanogaster | - |
? | - |
? | |
| additional information | Rattus norvegicus | - |
? | - |
? | |
| additional information | Mus musculus | involved in trimming reactions in N-glycan maturation in the Golgi complex | ? | - |
? | |
| additional information | Homo sapiens | involved in trimming reactions in N-glycan maturation in the Golgi complex | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | rat | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl alpha-D-mannoside + H2O | - |
Drosophila melanogaster | 4-nitrophenol + alpha-D-mannose | - |
? | |
| 4-nitrophenyl alpha-D-mannoside + H2O | - |
Homo sapiens | 4-nitrophenol + alpha-D-mannose | - |
? | |
| 4-nitrophenyl alpha-D-mannoside + H2O | rat | Rattus norvegicus | 4-nitrophenol + alpha-D-mannose | - |
? | |
| D-Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O | - |
Mus musculus | D-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + alpha-D-mannose | - |
? | |
| D-Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O | - |
Homo sapiens | D-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + alpha-D-mannose | - |
? | |
| D-Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O | - |
Rattus norvegicus | D-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + alpha-D-mannose | - |
? | |
| additional information | - |
Drosophila melanogaster | ? | - |
? | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| additional information | involved in trimming reactions in N-glycan maturation in the Golgi complex | Mus musculus | ? | - |
? | |
| additional information | involved in trimming reactions in N-glycan maturation in the Golgi complex | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Golgi mannosidase IIx | close homolog to Golgi mannosidase II with different substrate specificity | Mus musculus |
| Golgi mannosidase IIx | close homolog to Golgi mannosidase II with different substrate specificity | Homo sapiens |
| More | member of glycosyl hydrolase family 38 | Drosophila melanogaster |
| More | member of glycosyl hydrolase family 38 | Mus musculus |
| More | member of glycosyl hydrolase family 38 | Homo sapiens |
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