Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.2.1.114: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

This is an abbreviated version!
For detailed information about mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, go to the full flat file.

Word Map on EC 3.2.1.114

Reaction

Man5GlcNAc3-[protein]
+ 2 H2O =
Man3GlcNAc3-[protein]
 + 2 alpha-D-mannopyranose

Synonyms

1,3(1,6)-alpha-D-mannosidase, 1,6-alpha-D-mannosidase, Afams1, alpha-1,3 mannosidase, alpha-1,3-mannosidase, alpha-D-mannosidase II, alpha-mannosidase, alpha-mannosidase II, alpha-mannosidase III, alpha-mannosidase IIx, alpha-MII, alpha1-3,6-mannosidase, Bt3991, class II alpha-D-mannosidase, class II alpha-mannosidase, class IIC alpha-mannosidase, dGMII, Drosophila GMII, exo-1,3-1,6-alpha-mannosidase, GH38 alpha-mannosidase II, GH38 enzyme, GH38 Golgi alpha-mannosidase II, GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase, glycoside hydrolase, GmII, Golgi alpha-mannosidase II, Golgi mannosidase IIx, human type II alpha-mannosidase, jack bean alpha-mannosidase, Man II, MAN IIx, MAN2A1, ManII, ManIII, mannose-trimming enzyme, mannosidase II, mannosidase, exo-1,3-1,6-alpha-, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase II, MII, More, NAM, neutral alpha-mannosidase, SpGH38, TM1851

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

Disease

topprint

Disease on EC 3.2.1.114 - mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
alpha-Mannosidosis
Golgi alpha-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals.
Anemia
A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus.
Golgi alpha-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals.
Anemia, Dyserythropoietic, Congenital
A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus.
Golgi alpha-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals.
Carcinoma
Swainsonine, an inhibitor of glycoprotein processing, enhances cytotoxicity of large granular lymphocytes.
Carcinoma, Hepatocellular
Processing by endoplasmic reticulum mannosidases partitions a secretion-impaired glycoprotein into distinct disposal pathways.
Diabetes Mellitus, Type 2
Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: a case-control study and meta-analysis.
Infections
Antibody-independent, complement-mediated enhancement of HIV-1 infection by mannosidase I and II inhibitors.
Infertility, Male
The in vivo role of alpha-mannosidase IIx and its role in processing of N-glycans in spermatogenesis.
Leukemia
Sensitivity to alpha/beta-interferon is independent of N-linked complex-type oligosaccharides on cell-surface-membrane glycoproteins.
The presence of concanavalin-A(Con-A)-like molecules on natural-killer (NK)-sensitive target cells: their possible role in swainsonine-augmented human NK cytotoxicity.
Lung Neoplasms
Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors.
Lymphoma
N-glycosylation in expression and function of beta-adrenergic receptors.
Lysosomal Storage Diseases
A swainsonine survey of North American Astragalus and Oxytropis taxa implicated as locoweeds.
Fungicide treatment and clipping of Oxytropis sericea does not disrupt swainsonine concentrations.
Golgi alpha-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals.
Swainsonine-containing plants and their relationship to endophytic fungi.
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase deficiency
Golgi alpha-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals.
Melanoma
Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors.
Neoplasm Metastasis
The inhibition of platelet aggregation of metastatic H-ras-transformed 10T1/2 fibroblasts with castanospermine, an N-linked glycoprotein processing inhibitor.
Neoplasms
Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors.
MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice.
Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human ?-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors.
Measuring swainsonine in serum of cancer patients: phase I clinical trial.
Morphological changes in the Golgi complex correlate with actin cytoskeleton rearrangements.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genome-wide association study of childhood acute lymphoblastic leukemia in Korea.
Vesicular Stomatitis
A novel glycosylation phenotype expressed by Lec23, a Chinese hamster ovary mutant deficient in alpha-glucosidase I.
Morphological and functional association of Sec22b/ERS-24 with the pre-Golgi intermediate compartment.