3.2.1.114: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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For detailed information about mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, go to the full flat file.

Reaction

Synonyms

1,3(1,6)-alpha-D-mannosidase, 1,6-alpha-D-mannosidase, Afams1, alpha-1,3 mannosidase, alpha-1,3-mannosidase, alpha-D-mannosidase II, alpha-mannosidase, alpha-mannosidase II, alpha-mannosidase III, alpha-mannosidase IIx, alpha-MII, alpha1-3,6-mannosidase, Bt3991, class II alpha-D-mannosidase, class II alpha-mannosidase, class IIC alpha-mannosidase, dGMII, Drosophila GMII, exo-1,3-1,6-alpha-mannosidase, GH38 alpha-mannosidase II, GH38 enzyme, GH38 Golgi alpha-mannosidase II, GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase, glycoside hydrolase, GmII, Golgi alpha-mannosidase II, Golgi mannosidase IIx, human type II alpha-mannosidase, jack bean alpha-mannosidase, Man II, MAN IIx, MAN2A1, ManII, ManIII, mannose-trimming enzyme, mannosidase II, mannosidase, exo-1,3-1,6-alpha-, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase II, MII, More, NAM, neutral alpha-mannosidase, SpGH38, TM1851

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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Results	in table
12	Activating Compound
28	AA Sequence
11	Application
2	CAS Registry Number
18	Cloned(Commentary)
18	Crystallization (Commentary)
78	Disease/ Diagnostics
1	Expression
8	General Information
10	General Stability
43	IC50 Value
232	Inhibitors
6	kcat/KM [mM/s]
73	Ki Value [mM]
19	KM Value [mM]
70	Localization
71	Metals/Ions
37	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
96	Organism
5	Pathway
67	PDB ID
31	pH Optimum
8	pH Range
10	pH Stability
5	pI Value
21	Posttranslational Modification
14	Protein Variants
30	Purification (Commentary)
5	Reaction
6	Reaction Type
91	Reference
82	Source Tissue
16	Specific Activity [micromol/min/mg]
11	Storage Stability
219	Substrates and Products (Substrate)
30	Subunits
108	Synonyms
1	Systematic Name
37	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
7	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 3.2.1.114 - mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

30 - 90

Aspergillus fischeri

-

activity is reduced by 8% at 50°C while positive ellipticity at 190-195 nm is almost same in the temperature range of 35-50°C. The activity is not affected in this range. At 60°C, 18% and at 70°C and above, 25% loss in the alpha-helical content of the protein occurs with significant decrease in the positive ellipticity, the protein does not completely unfold at 90°C

709324

37

2 entries

40

Rattus norvegicus

-

and below, 15 min stable, rapid inactivation above, Zn2+ or 0.125 mg/l bovine serum albumin stabilizes

136013

50

Rattus norvegicus

-

3 h, about 30% loss of activity, 4-nitrophenyl alpha-D-mannoside or (Man)9GlcNAc as substrate

135998

37

Rattus norvegicus

-

stable at pH 7-9, unstable at acidic pH-values, Zn2+ stabilizes

136013

37

Rattus norvegicus

-

24 h, in 100 mM sodium acetate buffer, pH 5.8, 30-50% loss of activity

135998