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Enzyme Nomenclature
Information on EC 3.4.24.3 - microbial collagenase
for references in articles please use BRENDA:EC3.4.24.3
Word Map on EC 3.4.24.3
- 3.4.24.3
- bone
- trypsin
- hemorrhage
- collagenases
- pepsin
-
intracerebral
- cartilage
-
procollagens
-
fibril
- hydroxyproline
-
basement
- tendon
-
noncollagenous
-
proteoglycans
-
metalloproteinases
-
gelatinase
-
dentin
-
demineralize
-
collagen-like
-
articular
-
hematoma
-
triple-helical
-
collagenase-induced
-
intrastriatal
-
tensile
- hydroxylysine
-
collagen-binding
- chondroitinase
-
pepsin-resistant
-
collagenase-resistant
-
collagenase-treated
-
microfibrils
-
3hproline
-
ich-induced
-
collagenase-sensitive
-
unreduced
-
arylsulfonyl
-
collagenase-digestible
-
perihematomal
-
microfibrillar
- dupuytren
- stromelysin
- medicine
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
3.4.24.3
-
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RECOMMENDED NAME
GeneOntology No.
microbial collagenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Digestion of native collagen in the triple helical region at -/-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
endopeptidase
-
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CAS REGISTRY NUMBER
COMMENTARY
9001-12-1
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
37088, 37091, 37094, 37096, 37098, 37109, 37111, 654953, 654959, 656111, 656374, 657141, 683236, 683379, 683752, 684110, 696539, 717249, 717687, 717707, 717918, 718435, 733994, 81585
-
-
2-6 different collagenase fractions can be differentiated on the basis of substrate preference
-
-
2-6 different collagenase fractions can be differentiated on the basis of substrate preference; 2 multiple forms: I and II differ in substrate specificity
-
-
3 forms: A-alpha, B-alpha and B-beta differ in substrate specificity
-
-
6 forms: alpha, beta, gamma, delta, epsilon, zeta differ in substrate specificity
-
-
chemovar iophagus, two forms: A1 and A2 without difference in substrate specificity
-
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-(S-methylcysteine)-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-(S-methylcysteine)-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00018
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ala-Gly-Pro-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ala-Gly-Pro-beta-Ala
-
ratio of turnover number to Km-value is 0.00204
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ala-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Ala-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00095
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ala-Tyr-Lys-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ala-Tyr-Lys-beta-Ala
-
ratio of turnover number to Km-value is 0.00309
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Arg-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Arg-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00026
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Asn-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Asn-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Asp-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Asp-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gln-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gln-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.0003
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Glu-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Glu-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-(S-methylcysteine)-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-(S-methylcysteine)-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00072
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00082
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Arg-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Arg-beta-Ala
-
ratio of turnover number to Km-value is 0.00595
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00037
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Gly-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Gly-beta-Ala
-
ratio of turnover number to Km-value is 0.00124
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Ile-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Ile-beta-Ala
-
ratio of turnover number to Km-value is 0.00086
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Leu-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Leu-beta-Ala
-
ratio of turnover number to Km-value is 0.00134
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Lys-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Lys-beta-Ala
-
ratio of turnover number to Km-value is 0.006
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Met-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Met-beta-Ala
-
ratio of turnover number to Km-value is 0.00131
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Phe-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Phe-beta-Ala
-
ratio of turnover number to Km-value is 0.00051
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Pro-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Pro-beta-Ala
-
ratio of turnover number to Km-value is 0.00565
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Trp-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Trp-beta-Ala
-
ratio of turnover number to Km-value is 0.00073
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Tyr-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Tyr-beta-Ala
-
ratio of turnover number to Km-value is 0.00113
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Val-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Val-beta-Ala
-
ratio of turnover number to Km-value is 0.00056
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Asn-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Asn-beta-Ala
-
ratio of turnover number to Km-value is 0.00376
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Asp-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Asp-beta-Ala
-
ratio of turnover number to Km-value is 0.00043
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Gln-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Gln-beta-Ala
-
ratio of turnover number to Km-value is 0.00435
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Glu-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Glu-beta-Ala
-
ratio of turnover number to Km-value is 0.00042
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ser-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ser-beta-Ala
-
ratio of turnover number to Km-value is 0.00405
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Thr-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Thr-beta-Ala
-
ratio of turnover number to Km-value is 0.00466
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Arg-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Arg-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00011
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Asn-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Asn-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00096
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Asp-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Asp-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.0004
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Gln-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Gln-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00049
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Glu-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Glu-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00035
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Gly-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Gly-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00042
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-His-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-His-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00084
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ile-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ile-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00065
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Leu-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Leu-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00029
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Lys-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Lys-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00017
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Met-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Met-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00027
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Phe-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Phe-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00056
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.008
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ser-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ser-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00098
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Thr-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Thr-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00082
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Trp-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Trp-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00037
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Tyr-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Tyr-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00038
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Val-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Val-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00039
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-His-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-His-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00029
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ile-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ile-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00017
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Leu-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Leu-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00021
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Lys-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Lys-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00021
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Met-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Met-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00028
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Phe-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Phe-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Pro-Lys-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Pro-Lys-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00276
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Pro-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Pro-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00088
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ser-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ser-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.0007
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Thr-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Thr-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.0004
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Trp-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Trp-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00014
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Tyr-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Tyr-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00029
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Val-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Val-Pro-Ala-beta-Ala
-
ratio of turnover number to Km-value is 0.00036
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
Collagen type III + H2O
?
-
-
Clostridium collagenase itself and the degradation products of type I and III collagens lead toan increase in keratinocyte and fibroblast migration
-
?
collagen type IV + H2O
?
-
-
degradation products of collagen type IV induce fibroblast migration
-
?
furanacryloyl-Leu-Gly-Pro-Ala + H2O
furanacryloyl-Leu + Gly-Pro-Ala
-
-
-
-
?
2-furanacryloyl-Leu-Gly-Pro-Ala + H2O
2-furanacryloyl-Leu + Gly-Pro-Ala
-
-
-
?
2-furanacryloyl-Leu-Gly-Pro-Ala + H2O
2-furanacryloyl-Leu + Gly-Pro-Ala
-
-
-
?
2-furanacryloyl-Leu-Gly-Pro-Ala + H2O
2-furanacryloyl-Leu + Gly-Pro-Ala
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
-
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
-
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
-
-
-
-
?
Azocoll + H2O
Hydrolyzed azocoll
-
denatured collagen with bound dye, no hydrolysis
-
-
-
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
-
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
-
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
-
-
-
?
carbobenzoxy-Gly-Pro-Leu-Gly-Pro + H2O
carbobenzoxy-Gly-Pro-Leu + Gly-Pro
-
-
-
-
?
carbobenzoxy-Gly-Pro-Leu-Gly-Pro + H2O
carbobenzoxy-Gly-Pro-Leu + Gly-Pro
-
-
-
?
Collagen + H2O
?
Clostridium capitorale
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
clostridial collagenase A is effective in degrading collagen in eschar tissue and promoting healing in partial-thickness burns, CCA aggravates the systemic inflammatory response in rats with partial-thickness burns, inflammatory reactions such as fever, leukocytosis or leukocytopenia and increased CRP levels in sera are often observed in a significant proportion of burn victims treated with CCA ointment, although synchronous wound swab cultures show no signs of infection, overview
-
-
?
Collagen + H2O
?
Clostridium welchii
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
a collagen-binding domain specifically recognizes the triple-helical conformation made by three chains in the collagenous region
-
-
?
Collagen + H2O
?
-
proteolytic degradation, the enzyme helps the skin to heal after burns and dermal ulcers, but can cause allergic reactions, overview
-
-
?
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
Hydrolyzed collagen
Clostridium capitorale
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
Clostridium welchii
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen type I + H2O
?
-
-
Clostridium collagenase itself and the degradation products of type I and III collagens lead toan increase in keratinocyte and fibroblast migration
-
?
Collagen type I + H2O
?
-
tensile loads higher than 3 pN tenfold reduce the enzymatic degradation rate of recombinant human type I collagen monomers compared to unloaded controls. Collagen molecular architecture may be generally more stable when mechanically strained in tension. The tensile mechanical state of collagen monomers is likely to be correlated to their longevity in tissues
-
-
?
furylacryloyl-Leu-Gly-Pro-Ala + H2O
furylacryloyl-Leu + Gly-Pro-Ala
-
-
-
-
?
furylacryloyl-Leu-Gly-Pro-Ala + H2O
furylacryloyl-Leu + Gly-Pro-Ala
-
-
-
-
?
Type I collagen + H2O
?
-
bovine substrate from corium, degradation, cleavage at multiple sites by the bacterial enzyme
-
-
?
additional information
?
-
-
other forms with broader specificity isolated from the same source: collagenase B, collagenase II, pseudocollagenase
-
-
-
additional information
?
-
-
minimum sequence requirement: R-Pro-X-Gly-Pro, Pro can be substituted by Hyp and the first imino group must be blocked, cleavage between X and Gly
-
-
-
additional information
?
-
-
the N-terminal region of the collagen-binding region is not an essential structural component for collagen binding or recognition but rather a cation-controlled multiconformational domain-linker
-
-
-
additional information
?
-
-
human dentin surfaces bonded to adhesive material in teeth repair are sensitive to aging, microtensile bond strength values are affected by different adhesives, specimen sizes and storing periods, but not by the presence or absence of bacterial collagenase, overview
-
-
-
additional information
?
-
two-step mechanism in which the N-terminal activator domain cooperates with the peptidase domain in recognition and processing of both collagen triple helices and microfibrils. The activator and peptidase domains remain mostly closed during collagen cleavage but relax to the open ground state once the collagen is degraded, as collagen is the source of the attractive interaction for collagenase closing
-
-
-
additional information
?
-
-
bacterial collagenases of similar specificity isolated from Bacteroides melaninogenius
-
-
-
additional information
?
-
-
collagenase is capable of eliciting a variety of tissue responses in mice depending upon its route of administration. Intranasal instillation results in confluent pulmonary hemorrhage, intraperitoneal injections result in severe abdominal hemorrhage with foci in the intestinal serosa. Intravenous injections elicit abdominal hemorrhage and petichial hemorrhage with focal necrosis of the lungs, subcutaneous injections result in necrotic, ulcerating lesions
-
-
-
additional information
?
-
-
other forms with broader specificity isolated from the same source: collagenase B, collagenase II, pseudocollagenase
-
-
-
additional information
?
-
-
minimum sequence requirement: R-Pro-X-Gly-Pro, Pro can be substituted by Hyp and the first imino group must be blocked, cleavage between X and Gly
-
-
-
additional information
?
-
-
other forms with broader specificity isolated from the same source: collagenase B, collagenase II, pseudocollagenase
-
-
-
additional information
?
-
-
minimum sequence requirement: R-Pro-X-Gly-Pro, Pro can be substituted by Hyp and the first imino group must be blocked, cleavage between X and Gly
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Collagen + H2O
?
Clostridium capitorale
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
clostridial collagenase A is effective in degrading collagen in eschar tissue and promoting healing in partial-thickness burns, CCA aggravates the systemic inflammatory response in rats with partial-thickness burns, inflammatory reactions such as fever, leukocytosis or leukocytopenia and increased CRP levels in sera are often observed in a significant proportion of burn victims treated with CCA ointment, although synchronous wound swab cultures show no signs of infection, overview
-
-
?
Collagen + H2O
?
Clostridium welchii
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
proteolytic degradation, the enzyme helps the skin to heal after burns and dermal ulcers, but can cause allergic reactions, overview
-
-
?
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
additional information
?
-
-
human dentin surfaces bonded to adhesive material in teeth repair are sensitive to aging, microtensile bond strength values are affected by different adhesives, specimen sizes and storing periods, but not by the presence or absence of bacterial collagenase, overview
-
-
-
additional information
?
-
-
collagenase is capable of eliciting a variety of tissue responses in mice depending upon its route of administration. Intranasal instillation results in confluent pulmonary hemorrhage, intraperitoneal injections result in severe abdominal hemorrhage with foci in the intestinal serosa. Intravenous injections elicit abdominal hemorrhage and petichial hemorrhage with focal necrosis of the lungs, subcutaneous injections result in necrotic, ulcerating lesions
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Calcium
-
binding of calcium ions triggers the formation of a cis peptide bond in the collagen-binding domain. The calcium ions not only stabilize the cis peptide bond thermodynamically but also catalyze its formation. The free energy barrier to the formation of the cis peptide bond decreases from 21.4 kcal/mol in the absence of calciumions to 10.3 kcal/mol in their presence. The calcium ions electrostatically stabilize the lone pair on the nitrogen atom that forms during the isomerization. Their attraction to acidic amino acid side chains and formation of a hydrogen bond network constrain the peptide backbone in a way that makes it easier for the nitrogen to pyramidalize
Co2+
-
activates at low concentration, inhibits at high concentration
Mg2+
Zinc
Zn2+
Ca2+
-
Ca-enzyme, alpha: 2.2, beta: 7.9, gamma: 3.1, delta: 3.0, epsilon: 4. 5, zeta: 6.5 mol Ca2+ per mol enzyme
Ca2+
-
conformational change of the linker upon calcium binding in the structure of the collagen-binding domain with an N-terminal domain linker from class I collagenase
Ca2+
-
interdomain flexibility and the domain arrangement of full-length collagenase H are reversibly regulated by Ca2+
Zinc
-
expression of a truncated construct Y53-A506 which stops shortly after the third zinc binding residue and consitstent with the prediction of a minimal catalytic domain. The construct shows no catalytic activity at all, despite containing all zinc binding residues including the catalytic glutamate that is supposed to act as general base
Zn2+
-
zinc enzyme, 1.14 mol zinc per mol, enzyme form C1, 0.82 mol zinc per mol enzyme, form C3
Zn2+
the catalytic domain contains the consensus motif HEXXH that harbours the catalytic Zn2+ ion, in contrast to the zinc ligation in metzincins such as MMPs, bacterial collagenases are believed to employ glutamate as a third zinc ligand
Zn2+
the catalytic Zn2+ is tetrahedrally coordinated by the side chains of His523, His527 and Glu555, as well as a water molecule that is further hydrogen-bonded to the general base Glu524
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-(1-benzyl-3-naphthalen-1-yl-ureido)-N-hydroxy-3-methyl-butyramide
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)-N-hydroxypropanamide
-
-
2-[benzyl(5-methylnaphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
-
2-[benzyl-(2,4,6-tripropyl-benzenesulfonyl)-amino]-N-hydroxy-propionamide
-
-
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-N-hydroxy-propionamide
-
-
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-propionic acid
-
-
2-[benzyl-(3-tert-butoxycarbonylamino-4-methoxy-benzenesulfonyl)-amino]-propionic acid
-
-
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
-
-
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-propionic acid
-
-
2-[Benzyl-(5-methylnaphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
-
2-[benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-3-methyl-butyric acid
-
-
2-[Benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
-
2-[Benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
-
2-[Benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
-
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(heptadecfluorooctyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[[[3-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
-
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]-N-hydroxypropanamide
-
-
2-[[[4-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
-
3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
-
-
3-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
-
-
3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
-
-
4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
-
-
4-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
-
-
4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
-
-
isoamyl-phosphonyl-Gly-Pro-Ala
peptidomimetic inhibitor, binds to the edge strand in an antiparallel orientation
N-(2-chlorobenzyl)-N-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[(2-methylphenyl)sulfonyl]carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[(4-chlorophenyl)sulfonyl]carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[(4-fluorophenyl)sulfonyl]carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-L-alanine
-
-
N-([(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]amino]methyl)benzamide
-
-
N-([3-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
-
N-([3-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
-
N-([4-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
-
N-2-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-2-methylphenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-2-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-chlorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-chlorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-4-chlorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-fluorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N2(2-chlorobenzyl)-N-hydroxy-N2-[(trifluoromethyl)sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylcarbamoyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylsulfonyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-2-ylsulfonyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(quinolin-8-ylsulfonyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(thiophen-2-ylsulfonyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4,6-trimethylphenyl)sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4-dinitrophenyl)sulfanyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-nitrophenyl)sulfanyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(nonafluorobutyl)sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(trichloromethyl)sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(2,4-difluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(2,5-dichlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(2-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(3,4-dichlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(3-chloro-4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(3-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(3-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-bromophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-iodophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-methylphenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(heptadecafluorooctyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[[(2-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[[(4-chlorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[[(4-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-[[4-(acetylamino)phenyl]sulfonyl]-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
-
-
Tannic acid
-
competitive, almost complete inhibition. Pretreatment of collagen fibers with tannic acid results in polymerization and complex formation
tert-butyl (3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
-
-
tert-butyl (4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
-
-
tert-butyl (5-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]-2-methoxyphenyl)carbamate
-
-
[3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
-
-
[4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
-
-
[5-[benzyl-(3-hydroxy-1-methyl-2-oxo-propyl)-sulfamoyl]-2-methoxy-phenyl]-carbamic acid tert-butyl ester
-
-
1,10-phenanthroline
-
The half maximal inhibitory concentrations of the catalytic domains for 1,10-phenanthroline are significantly decreased in the presence of the N-terminal His6-tag
1,10-phenanthroline
-
The half maximal inhibitory concentrations of the catalytic domains for 1,10-phenanthroline are significantly decreased for both isoforms ColG and ColH in the presence of the N-terminal His6-tag
1,10-phenanthroline
-
activity restored by Co2+, Mn2+, Ca2+, Cu2+, Ni2+ and Zn2+
EGTA
-
Ca2+ chelation by EGTA induces interdomain conformational changes with an increase in the percent polydispersity as the Ca2+ is chelated, suggesting an increase in protein flexibility. The thermostability is decreased by Ca2+ chelation
additional information
-
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid
-
additional information
-
quantitative structure-activity relationship analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors, overview
-
additional information
-
modeling of Clostridium histolyticum collagenase inhibitors using molecular redundancy as a molecular descriptor in order to obtain statistically significant models. Then by performing regression analysis, the statistically most significant models are used for modeling the referred activity. Presence of any statistical draw back in the proposed model is discussed
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.425
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColH with N-terminal His6-tag, pH 7.5, 25°C
1.24
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColT with N-terminal His6-tag, pH 7.5, 25°C
1.26
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColG with N-terminal His6-tag, pH 7.5, 25°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.092
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColG with N-terminal His6-tag, pH 7.5, 25°C
3.65
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColT with N-terminal His6-tag, pH 7.5, 25°C
13.6
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColH with N-terminal His6-tag, pH 7.5, 25°C
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0056
2-(1-benzyl-3-naphthalen-1-yl-ureido)-3-methyl-butyric acid
-
pH 7.5, 25°C
0.000012
2-(1-benzyl-3-naphthalen-1-yl-ureido)-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25°C
0.000006
2-(3-benzoyl-1-benzyl-thioureido)-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25°C
0.0074
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000021
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000024
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0073
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)propanoic acid
-
pH 7.5, 25°C
0.0042
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000009
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.00001
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0048
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)propanoic acid
-
pH 7.5, 25°C
0.01
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000033
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000034
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25°C
0.011
2-(benzyl[[(3-chlorphenyl)amino]carbonyl]amino)propanoic acid
-
pH 7.5, 25°C
0.0083
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
pH 7.5, 25°C
0.00003
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.00003
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0088
2-(benzyl[[(4-chlorphenyl)amino]carbonyl]amino)propanoic acid
-
pH 7.5, 25°C
0.0091
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000031
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000033
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25°C
0.01
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)propanoic acid
-
pH 7.5, 25°C
0.000006
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0006
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)propanoic acid
-
pH 7.5, 25°C
0.0036
2-[benzyl(1-naphthylsulfonyl)amino]propanoic acid
-
pH 7.5, 25°C
0.0014
2-[benzyl(2-naphthylsulfonyl)amino]propanoic acid
-
pH 7.5, 25°C
0.002
2-[benzyl(5-methylnaphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.015
2-[benzyl(benzylsulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.00004
2-[benzyl(benzylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000043
2-[benzyl(benzylsulfonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.018
2-[benzyl(methylsulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000103
2-[benzyl(methylsulfonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0033
2-[benzyl(naphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.0014
2-[benzyl(naphthalene-2-sulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000005
2-[benzyl(phenylcarbonothioyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.02
2-[benzyl(phenylsulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000054
2-[benzyl(phenylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000051
2-[benzyl(phenylsulfonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0021
2-[benzyl(thien-2-ylsulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.00001
2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000011
2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0024
2-[benzyl(thien-2-ylsulfonyl)amino]propanoic acid
-
pH 7.5, 25°C
0.008
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000012
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000017
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
pH 7.5, 25°C
0.000014
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.009
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
pH 7.5, 25°C
0.0069
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000015
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000015
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
pH 7.5, 25°C
0.000015
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0064
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
pH 7.5, 25°C
0.0075
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000019
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000021
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
pH 7.5, 25°C
0.000018
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0082
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
pH 7.5, 25°C
0.007
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000013
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000016
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
pH 7.5, 25°C
0.000015
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0071
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
pH 7.5, 25°C
0.000019
2-[benzyl-(2,4,6-tripropyl-benzenesulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25°C
0.000008
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25°C
0.003
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-propionic acid
-
pH 7.5, 25°C
0.0031
2-[benzyl-(3-tert-butoxycarbonylamino-4-methoxy-benzenesulfonyl)-amino]-propionic acid
-
pH 7.5, 25°C
0.00001
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25°C
0.0025
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-propionic acid
-
pH 7.5, 25°C
0.000008
2-[Benzyl-(5-methylnaphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25°C
0.0019
2-[benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-3-methyl-butyric acid
-
pH 7.5, 25°C
0.000008
2-[Benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25°C
0.000009
2-[Benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25°C
0.00001
2-[benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25°C
0.000006
2-[Benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25°C
0.000009
2-[benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25°C
0.00004
2-[benzyl-(toluene-4-sulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25°C
0.000011
2-[benzyl[(1-naphthylamino)carbonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0051
2-[benzyl[(1-naphthylamino)carbonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0061
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000018
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.007
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000008
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.00001
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0071
2-[benzyl[(2,4-dinitrophenyl)thio]amino]propanoic acid
-
pH 7.5, 25°C
0.004
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000011
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000014
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0047
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0053
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000018
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000021
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0059
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0062
2-[benzyl[(2-nitrophenyl)thio]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000012
2-[benzyl[(2-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.0032
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000007
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.0033
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000007
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.0023
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000007
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.0045
2-[benzyl[(3-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.003
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000011
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000011
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.003
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0051
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000011
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000012
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0052
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.000012
2-[benzyl[(3-nitrophenyl)thio]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0063
2-[benzyl[(3-nitrophenyl)thio]amino]propanoic acid
-
pH 7.5, 25°C
0.0006
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000006
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.0035
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.00001
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.01
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000036
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000037
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.011
2-[benzyl[(4-bromophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0024
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000008
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.0024
2-[benzyl[(4-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.011
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000044
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000044
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.013
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.012
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000042
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000045
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.013
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.01
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.00003
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000032
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.01
2-[benzyl[(4-iodophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0063
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000017
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.00002
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.015
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000033
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.016
2-[benzyl[(4-methylphenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.005
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000015
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000015
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0055
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.006
2-[benzyl[(4-nitrophenyl)thio]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000013
2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000015
2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.006
2-[benzyl[(4-nitrophenyl)thio]amino]propanoic acid
-
pH 7.5, 25°C
0.041
2-[benzyl[(dimethylamino)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000065
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000068
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.04
2-[benzyl[(dimethylamino)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0018
2-[benzyl[(heptadecafluorooctyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.000007
2-[benzyl[(heptadecfluorooctyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0032
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.00001
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000012
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0031
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0004
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000005
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000006
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0005
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0056
2-[benzyl[(trichloromethyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000052
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.00005
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0055
2-[benzyl[(trichloromethyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0033
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25°C
0.000047
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25°C
0.000048
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0036
2-[benzyl[(trifluoromethyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25°C
0.0068
2-[[[2,4,6-(tripropyl)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
pH 7.5, 25°C
0.0022
2-[[[3-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
pH 7.5, 25°C
0.000012
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25°C
0.0036
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
pH 7.5, 25°C
0.0027
2-[[[4-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
pH 7.5, 25°C
0.0062
2-[[[4-(methoxy)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
pH 7.5, 25°C
0.000008
3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
-
pH 7.5, 25°C
0.0045
3-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid
-
pH 7.5, 25°C
0.000009
3-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
-
pH 7.5, 25°C
0.000009
3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
-
pH 7.5, 25°C
0.0041
3-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
-
pH 7.5, 25°C
0.000007
4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
-
pH 7.5, 25°C
0.0029
4-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid
-
pH 7.5, 25°C
0.000008
4-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
-
pH 7.5, 25°C
0.000007
4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
-
pH 7.5, 25°C
0.0038
4-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
-
pH 7.5, 25°C
0.005
N-(2-chlorobenzyl)-N-(naphthalen-1-ylcarbamoyl)-L-alanine
-
pH 7.5, 25°C
0.0016
N-(2-chlorobenzyl)-N-(naphthalen-1-ylsulfonyl)-L-alanine
-
pH 7.5, 25°C
0.0015
N-(2-chlorobenzyl)-N-(naphthalen-2-ylsulfonyl)-L-alanine
-
pH 7.5, 25°C
0.0068
N-(2-chlorobenzyl)-N-[(2,4,6-trimethylphenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0055
N-(2-chlorobenzyl)-N-[(2,4-difluorophenyl)carbamoyl]-L-alanine
-
pH 7.5, 25°C
0.0041
N-(2-chlorobenzyl)-N-[(2,5-dichlorophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0049
N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0058
N-(2-chlorobenzyl)-N-[(3,4-dichlorophenyl)carbamoyl]-L-alanine
-
pH 7.5, 25°C
0.0024
N-(2-chlorobenzyl)-N-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0031
N-(2-chlorobenzyl)-N-[(3-chloro-4-nitrophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0076
N-(2-chlorobenzyl)-N-[(3-chlorophenyl)carbamoyl]-L-alanine
-
pH 7.5, 25°C
0.005
N-(2-chlorobenzyl)-N-[(3-nitrophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.01
N-(2-chlorobenzyl)-N-[(4-bromophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0068
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)carbamoyl]-L-alanine
-
pH 7.5, 25°C
0.013
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0074
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)carbamoyl]-L-alanine
-
pH 7.5, 25°C
0.012
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.01
N-(2-chlorobenzyl)-N-[(4-iodophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.006
N-(2-chlorobenzyl)-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.018
N-(2-chlorobenzyl)-N-[(4-methylphenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0051
N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0015
N-(2-chlorobenzyl)-N-[(heptadecafluorooctyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.003
N-(2-chlorobenzyl)-N-[(nonafluorobutyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0052
N-(2-chlorobenzyl)-N-[(trichloromethyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0033
N-(2-chlorobenzyl)-N-[(trifluoromethyl)sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.004
N-(2-chlorobenzyl)-N-[[(2-methylphenyl)sulfonyl]carbamoyl]-L-alanine
-
pH 7.5, 25°C
0.0034
N-(2-chlorobenzyl)-N-[[(4-chlorophenyl)sulfonyl]carbamoyl]-L-alanine
-
pH 7.5, 25°C
0.0036
N-(2-chlorobenzyl)-N-[[(4-fluorophenyl)sulfonyl]carbamoyl]-L-alanine
-
pH 7.5, 25°C
0.0041
N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine
-
pH 7.5, 25°C
0.0005
N-(2-chlorobenzyl)-N-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.0021
N-(2-chlorobenzyl)-N-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-L-alanine
-
pH 7.5, 25°C
0.000006
N-([(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]amino]methyl)benzamide
-
pH 7.5, 25°C
0.003
N-([3-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
pH 7.5, 25°C
0.0024
N-([3-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
pH 7.5, 25°C
0.0027
N-([4-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
pH 7.5, 25°C
0.000189
N-2-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25°C
0.000028
N-2-methylphenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25°C
0.00015
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25°C
0.000021
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25°C
0.000061
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25°C
0.000043
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25°C
0.00002
N-2-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25°C
0.000045
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25°C
0.00004
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25°C
0.000015
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25°C
0.00017
N-4-chlorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25°C
0.000021
N-4-chlorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25°C
0.000125
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25°C
0.000014
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25°C
0.000009
N-4-chlorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25°C
0.000026
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25°C
0.000025
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25°C
0.000007
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25°C
0.000163
N-4-fluorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25°C
0.000018
N-4-fluorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25°C
0.00014
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25°C
0.000013
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25°C
0.00005
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25°C
0.00006
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25°C
0.000013
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25°C
0.000007
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25°C
0.000033
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25°C
0.00001
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25°C
0.000021
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25°C
0.000006
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25°C
0.000165
N-4-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25°C
0.000133
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25°C
0.000018
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25°C
0.000055
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25°C
0.000042
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25°C
0.000018
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25°C
0.000019
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25°C
0.00004
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25°C
0.000015
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25°C
0.000038
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25°C
0.000012
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25°C
0.000125
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25°C
0.000016
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25°C
0.000015
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25°C
0.00001
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25°C
0.000086
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25°C
0.000013
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25°C
0.000035
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25°C
0.000008
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25°C
0.003
N-[[4-(acetylamino)phenyl]sulfonyl]-N-(2-chlorobenzyl)-L-alanine
-
pH 7.5, 25°C
0.000076
N2(2-chlorobenzyl)-N-hydroxy-N2-[(trifluoromethyl)sulfonyl]-L-alaninamide
-
pH 7.5, 25°C
0.000011
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylcarbamoyl)-L-alaninamide
-
pH 7.5, 25°C
0.000008
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylsulfonyl)-L-alaninamide
-
pH 7.5, 25°C
0.000009
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-2-ylsulfonyl)-L-alaninamide
-
pH 7.5, 25°C
0.000007
N2-(2-chlorobenzyl)-N-hydroxy-N2-(quinolin-8-ylsulfonyl)-L-alaninamide
-
pH 7.5, 25°C
0.000011
N2-(2-chlorobenzyl)-N-hydroxy-N2-(thiophen-2-ylsulfonyl)-L-alaninamide
-
pH 7.5, 25°C
0.000017
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4,6-trimethylphenyl)sulfonyl]-L-alaninamide
-
pH 7.5, 25°C
0.000011
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4-dinitrophenyl)sulfanyl]-L-alaninamide
-
pH 7.5, 25°C
0.000022
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alaninamide
-
pH 7.5, 25°C
0.000013
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-nitrophenyl)sulfanyl]-L-alaninamide
-
pH 7.5, 25°C
0.000011
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(nonafluorobutyl)sulfonyl]-L-alaninamide
-
pH 7.5, 25°C
0.000071
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(trichloromethyl)sulfonyl]-L-alaninamide
-
pH 7.5, 25°C
0.000006
N2-(2-chlorobenzyl)-N-hydroxy-N2-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alaninamide
-
pH 7.5, 25°C
0.000077
N2-(2-chlorobenzyl)-N2-(dimethylsulfamoyl)-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000014
N2-(2-chlorobenzyl)-N2-[(2,4-difluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000015
N2-(2-chlorobenzyl)-N2-[(2,5-dichlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000016
N2-(2-chlorobenzyl)-N2-[(2-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000015
N2-(2-chlorobenzyl)-N2-[(3,4-dichlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000009
N2-(2-chlorobenzyl)-N2-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.00001
N2-(2-chlorobenzyl)-N2-[(3-chloro-4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000017
N2-(2-chlorobenzyl)-N2-[(3-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000011
N2-(2-chlorobenzyl)-N2-[(3-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000033
N2-(2-chlorobenzyl)-N2-[(4-bromophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000015
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000035
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000018
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000036
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.00003
N2-(2-chlorobenzyl)-N2-[(4-iodophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000045
N2-(2-chlorobenzyl)-N2-[(4-methylphenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000015
N2-(2-chlorobenzyl)-N2-[(4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000008
N2-(2-chlorobenzyl)-N2-[(heptadecafluorooctyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000011
N2-(2-chlorobenzyl)-N2-[[(4-chlorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000008 - 0.000009
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
0.00001
N2-(2-chlorobenzyl)-N2-[[(4-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.00001
N2-(2-chlorobenzyl)-N2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000054
N2-(benzylsulfonyl)-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000092
N2-chlorobenzyl)-N-hydroxy-N2-(methylsulfonyl)-L-alaninamide
-
pH 7.5, 25°C
0.000011
N2-[[4-(acetylamino)phenyl]sulfonyl]-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000008
tert-butyl (3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
-
pH 7.5, 25°C
0.000009
tert-butyl (4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
-
pH 7.5, 25°C
0.000008
tert-butyl (5-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]-2-methoxyphenyl)carbamate
-
pH 7.5, 25°C
0.000007
[3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
-
pH 7.5, 25°C
0.000009
[4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
-
pH 7.5, 25°C
0.000007
[5-[benzyl-(3-hydroxy-1-methyl-2-oxo-propyl)-sulfamoyl]-2-methoxy-phenyl]-carbamic acid tert-butyl ester
-
pH 7.5, 25°C
additional information
additional information
-
inhibition kinetics using diverse variants of 5-amino-2-mercapto-1,3,4-thiadiazoles, overview
-
0.002
N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine
-
pH 7.5, 25°C
0.0024
N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine
-
pH 7.5, 25°C
0.0000005
N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide
-
pH 7.5, 25°C
0.000058
N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide
-
pH 7.5, 25°C
0.000008
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000009
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25°C
0.000005
p-O2NC6H4CH2CH2PO(OH)Gly-Pro-2-aminohexanoic acid
-
pH 7.5, 25°C
-
0.34
p-O2NC6H4CH2CH2PO(OH)Gly-Pro-2-aminohexanoic acid
-
pH 7.5, 25°C
-
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.5
additional information
Hathewaya histolytica
-
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid
-
0.025
1,10-phenanthroline
Hathewaya histolytica
-
isoform ColH with N-terminal His6-tag, pH 7.5, 25°C
0.04
1,10-phenanthroline
Clostridium tetani
-
isoform ColT with N-terminal His6-tag, pH 7.5, 25°C
0.1
1,10-phenanthroline
Hathewaya histolytica
-
isoform ColG with N-terminal His6-tag, pH 7.5, 25°C
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
collagen-binding analysis, assay method, the three nonionic detergents, Triton X-100, Tween 20, and Tween 60, are ineffective for the release of the collagenolytic protease from collagen, overview
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5 - 8.8
7.5
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4.2 - 10.2
-
pH 10.2: about 85% of activity maximum; pH 4.2: about 20% of activity maximum
5 - 11
-
pH 11: about 35% of activity maximum; pH 5: about 35% of activity maximum
5.5 - 8.5
-
pH 5.5: about 40% of activity maximum; pH 8.5: about 20% of activity maximum
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
additional information
-
intimately associated with the cell but released during autolysis
-
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PDB
SCOP
CATH
ORGANISM
UNIPROT
Clostridium tetani (strain Massachusetts / E88)
Clostridium tetani (strain Massachusetts / E88)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT