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Literature summary for 3.4.24.3 extracted from
- Degradation of collagenous substrates by Bacteroides melaninogenicus (1961), J. Bacteriol., 81, 614-621.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | intimately associated with the cell but released during autolysis | Prevotella melaninogenica | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates | Prevotella melaninogenica |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Collagen + H2O | Prevotella melaninogenica | degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Prevotella melaninogenica | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| culture filtrate | - |
Prevotella melaninogenica | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 24 h, plus 10 mM cysteine | Prevotella melaninogenica |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Azocoll + H2O | - |
Prevotella melaninogenica | Hydrolyzed azocoll | - |
? | |
| Collagen + H2O | degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form | Prevotella melaninogenica | Hydrolyzed collagen | - |
? | |
| Collagen + H2O | degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro | Prevotella melaninogenica | ? | - |
? | |
| additional information | bacterial collagenases of similar specificity isolated from Bacteroides melaninogenius | Prevotella melaninogenica | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
10 min, 65% loss of activity | Prevotella melaninogenica |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | 7.3 | - |
Prevotella melaninogenica |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 8.5 | pH 5.5: about 40% of activity maximum | Prevotella melaninogenica |
| 5.5 | 8.5 | pH 8.5: about 20% of activity maximum | Prevotella melaninogenica |
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Release 2023.1 (January 2023)
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