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Literature summary for 3.4.24.3 extracted from
- Multiplicity of Clostridium histolyticum collagenases (1964), Biochemistry, 3, 1737-1741.
General Stability
| General Stability | Organism |
|---|---|
| Ca2+ stabilizes | Hathewaya histolytica |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required for stability and activity | Hathewaya histolytica |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 112000 | - |
ultracentrifugation | Hathewaya histolytica |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Collagen + H2O | Hathewaya histolytica | degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Hathewaya histolytica | - |
2 multiple forms: I and II differ in substrate specificity | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Azocoll + H2O | - |
Hathewaya histolytica | Hydrolyzed azocoll | - |
? | |
| carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O | - |
Hathewaya histolytica | carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala | - |
? | |
| carbobenzoxy-Gly-Pro-Leu-Gly-Pro + H2O | - |
Hathewaya histolytica | carbobenzoxy-Gly-Pro-Leu + Gly-Pro | - |
? | |
| Collagen + H2O | degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form | Hathewaya histolytica | Hydrolyzed collagen | - |
? | |
| Collagen + H2O | degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro | Hathewaya histolytica | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Hathewaya histolytica |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 11 | pH 5: about 35% of activity maximum | Hathewaya histolytica |
| 5 | 11 | pH 11: about 35% of activity maximum | Hathewaya histolytica |
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Release 2023.1 (January 2023)
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