BRENDA - Enzyme Database show
show all sequences of 3.4.24.3

Studies on collagen-tannic acid-collagenase ternary system: Inhibition of collagenase against collagenolytic degradation of extracellular matrix component of collagen

Krishnamoorthy, G.; Sehgal, P.K.; Mandal, A.B.; Sadulla, S.; J. Enzyme Inhib. Med. Chem. 27, 451-457 (2011)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Tannic acid
competitive, almost complete inhibition. Pretreatment of collagen fibers with tannic acid results in polymerization and complex formation
Hathewaya histolytica
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.555
-
N-[3-(2-furyl) acryloyl]-L-Leu-Gly-L-Pro-L-Ala
pH 7.5, 25C
Hathewaya histolytica
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Hathewaya histolytica
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N-[3-(2-furyl) acryloyl]-L-Leu-Gly-L-Pro-L-Ala + H2O
-
717918
Hathewaya histolytica
?
-
-
-
?
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.02
-
Tannic acid
pH 7.5, 25C
Hathewaya histolytica
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Tannic acid
competitive, almost complete inhibition. Pretreatment of collagen fibers with tannic acid results in polymerization and complex formation
Hathewaya histolytica
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.02
-
Tannic acid
pH 7.5, 25C
Hathewaya histolytica
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.555
-
N-[3-(2-furyl) acryloyl]-L-Leu-Gly-L-Pro-L-Ala
pH 7.5, 25C
Hathewaya histolytica
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N-[3-(2-furyl) acryloyl]-L-Leu-Gly-L-Pro-L-Ala + H2O
-
717918
Hathewaya histolytica
?
-
-
-
?
Other publictions for EC 3.4.24.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
734583
Uchida
Enhancement of periosteal bone ...
Hathewaya histolytica
J. Tissue Eng. Regen. Med.
11
1165-1172
2017
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1
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1
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3
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733013
Bauer
Structures of three polycystic ...
Hathewaya histolytica
Acta Crystallogr. Sect. D
71
565-577
2015
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1
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3
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733994
Rathore
-
Role of molecular redundancy i ...
Hathewaya histolytica
Int. J. Chem. Sci.
11
911-924
2013
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734083
Bauer
Structural comparison of ColH ...
Hathewaya histolytica
J. Bacteriol.
195
318-327
2013
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2
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734216
Eckhard
Structural basis for activity ...
Clostridium tetani, Clostridium tetani E88, Hathewaya histolytica
J. Biol. Chem.
288
20184-20194
2013
-
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2
2
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4
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733162
Ohbayashi
Enhancement of the structural ...
Hathewaya histolytica
Appl. Environ. Microbiol.
78
5839-5844
2012
-
-
1
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1
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1
3
-
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3
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1
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1
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3
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1
1
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2
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717707
Camp
Molecular mechanochemistry: lo ...
Hathewaya histolytica
J. Am. Chem. Soc.
133
4073-4078
2011
-
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4
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1
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717918
Krishnamoorthy
Studies on collagen-tannic aci ...
Hathewaya histolytica
J. Enzyme Inhib. Med. Chem.
27
451-457
2011
-
-
-
-
-
-
1
1
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-
2
-
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1
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1
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1
1
1
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1
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718155
Eckhard
Structure of collagenase G rev ...
Hathewaya histolytica
Nat. Struct. Mol. Biol.
18
1109-1114
2011
-
-
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1
1
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1
-
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1
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4
-
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1
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1
1
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1
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1
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1
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718435
Breite
Characterization and functiona ...
Hathewaya histolytica
Transplant. Proc.
43
3171-3175
2011
-
-
-
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-
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1
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1
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1
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2
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1
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1
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2
-
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717249
Spiriti
Mechanism of the calcium-induc ...
Hathewaya histolytica
Biochemistry
49
5314-5320
2010
-
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1
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2
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717687
Shi
Degradation of human collagen ...
Hathewaya histolytica
Int. Wound J.
7
87-95
2010
-
1
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1
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5
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1
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5
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696539
Eckhard
Biochemical characterization o ...
Clostridium tetani, Hathewaya histolytica
Biol. Chem.
390
11-18
2009
-
-
2
-
3
-
2
6
-
1
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3
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2
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6
-
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6
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2
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3
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6
2
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6
-
1
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2
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6
-
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683029
Eckhard
Crystallization and preliminar ...
Hathewaya histolytica
Acta Crystallogr. Sect. F
64
419-421
2008
-
-
1
1
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1
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3
-
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1
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1
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1
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1
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1
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1
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1
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683324
Dokumcu
Clostridial collagenase aggrav ...
Clostridium sp.
Burns
34
935-941
2008
-
-
-
-
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1
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2
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2
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683379
Foti
Contact dermatitis with clostr ...
Hathewaya histolytica
Contact Derm.
56
361-362
2007
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1
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683752
Toledano
Effect of bacterial collagenas ...
Hathewaya histolytica
J. Mater. Sci. Mater. Med.
18
2355-2361
2007
-
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1
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2
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1
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684110
Metzmacher
In vitro binding of matrix met ...
Hathewaya histolytica
Wound Repair Regen.
15
549-555
2007
-
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1
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2
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2
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1
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1
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683236
Jamloki
QSAR analysis of some 5-amino- ...
Hathewaya histolytica
Bioorg. Med. Chem. Lett.
16
3847-3854
2006
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5
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683603
Itoi
Characteristic features in the ...
Geobacillus sp., Geobacillus sp. MO-1
J. Bacteriol.
188
6572-6579
2006
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668044
Kang
-
Purification and properties of ...
Vibrio vulnificus, Vibrio vulnificus CYK279H
Biotechnol. Bioprocess Eng.
10
593-598
2005
-
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3
-
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3
1
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2
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1
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2
1
1
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1
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1
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1
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3
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3
1
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1
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2
1
1
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1
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1
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1
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654953
Ilies
Protease inhibitors: synthesis ...
Hathewaya histolytica
Bioorg. Med. Chem.
11
2227-2239
2003
-
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-
53
-
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2
-
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-
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1
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53
-
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53
53
-
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1
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655332
Wilson
A bacterial collagen-binding d ...
Hathewaya histolytica
EMBO J.
22
1743-1752
2003
-
-
-
1
9
-
-
-
-
1
21
-
-
1
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
-
-
-
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1
9
-
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1
21
-
-
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-
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-
1
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-
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-
-
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656111
Hu
Rapid determination of substra ...
Hathewaya histolytica
J. Biol. Chem.
277
8366-8371
2002
-
-
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-
-
-
-
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1
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-
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-
60
-
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-
-
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-
-
-
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-
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-
-
-
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60
-
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-
657141
Rennert
Free fatty acids inhibit the a ...
Hathewaya histolytica
Planta Med.
68
767-769
2002
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-
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11
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12
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Substrate recognition by the c ...
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1
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654959
Scozzafava
Protease inhibitors. Part 8. S ...
Hathewaya histolytica
Bioorg. Med. Chem.
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91
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2
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91
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91
91
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2
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655500
Supuran
Protease inhibitors. Part 7 In ...
Hathewaya histolytica
Eur. J. Pharm. Sci.
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67-76
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-
-
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96
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1
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95
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96
95
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1
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656374
Supuran
Protease inhibitors: synthesis ...
Hathewaya histolytica
J. Enzyme Inhib.
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111-128
2000
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-
-
-
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96
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2
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1
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96
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96
96
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1
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37108
Yu
Expression and characterizatio ...
Vibrio parahaemolyticus
Microbiology
145
143-150
1999
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-
1
-
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-
5
2
-
-
2
1
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1
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1
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3
1
1
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1
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1
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5
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2
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2
1
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1
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3
1
1
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-
1
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37109
Matsushita
A study of the collagen-bindin ...
Hathewaya histolytica
J. Biol. Chem.
273
3643-3648
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1
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1
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3
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1
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3
-
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37111
Jung
Expression of the colH gene en ...
Hathewaya histolytica
Microbiol. Immunol.
40
923-929
1996
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-
1
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-
-
-
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1
1
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5
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1
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1
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3
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1
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1
1
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1
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1
-
3
-
-
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-
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-
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-
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37112
Vos-Scheperkeuter
Collagen degradation by three ...
Hathewaya histolytica
Transplant. Proc.
26
641-642
1994
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-
-
-
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1
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2
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2
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2
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37113
Sasagawa
Purification and properties of ...
Cytophaga sp., Cytophaga sp. L43-1
Biosci. Biotechnol. Biochem.
57
1894-1898
1993
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-
-
-
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1
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2
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2
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1
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1
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11
-
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1
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2
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1
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1
-
11
-
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-
-
-
-
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-
-
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37114
Dive
Peptide inhibitors of E. colla ...
Empedobacter collagenolyticum
Int. J. Pept. Protein Res.
39
506-515
1992
-
-
-
-
-
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3
-
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1
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1
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2
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1
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2
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37117
Lawson
Biochemical characterization o ...
Porphyromonas gingivalis
Infect. Immun.
60
1524-1529
1992
1
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-
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1
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1
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1
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1
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2
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1
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1
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1
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1
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2
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37118
French
Identification of Clostridium ...
Hathewaya histolytica
J. Protein Chem.
11
83-97
1992
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2
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2
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37106
Endo
Purification and properties of ...
Streptomyces sp.
J. Biochem.
102
163-170
1987
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1
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1
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1
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2
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1
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1
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1
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1
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1
1
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1
1
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-
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2
-
1
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1
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1
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37110
Makinen
Purification and properties of ...
Bacillus cereus
J. Biol. Chem.
262
12488-12495
1987
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4
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1
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8
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4
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2
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1
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1
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8
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37105
Chakraborty
Purification and characterizat ...
Streptomyces sp.
J. Appl. Bacteriol.
61
331-337
1986
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6
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1
2
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1
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1
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3
2
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6
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1
2
1
1
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1
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1
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3
2
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37115
Tong
-
Purification and characterizat ...
Vibrio alginolyticus
Biochim. Biophys. Acta
874
296-304
1986
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1
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1
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1
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4
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1
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2
1
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1
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1
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4
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37091
Bicsak
Purification of nonspecific pr ...
Hathewaya histolytica
Anal. Biochem.
145
286-291
1985
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1
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1
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1
1
1
2
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1
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1
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1
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1
1
1
2
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-
-
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-
-
-
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-
-
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-
37116
Van Wart
Complementary substrate specif ...
Hathewaya histolytica
Biochemistry
24
6520-6526
1985
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-
-
-
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1
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1
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1
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3
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1
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1
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-
-
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3
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-
-
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-
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-
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-
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37093
Sugasawara
Purification and characterizat ...
Hathewaya histolytica
Biochemistry
23
5175-5181
1984
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-
-
-
-
-
-
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1
3
1
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3
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1
1
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-
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2
1
-
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-
-
-
-
-
-
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-
-
-
-
-
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-
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1
3
1
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1
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
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-
37096
Bond
Characterization of the indivi ...
Hathewaya histolytica
Biochemistry
23
3085-3091
1984
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-
-
-
-
-
-
1
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2
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1
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1
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-
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2
-
-
-
-
-
-
-
-
-
-
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-
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-
1
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2
-
1
-
-
-
-
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-
-
-
2
-
-
-
-
-
-
-
-
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-
-
-
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37097
Bond
Purification and separation of ...
Hathewaya histolytica
Biochemistry
23
3077-3085
1984
-
-
-
-
-
-
-
-
-
-
-
1
-
1
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1
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1
-
-
3
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
1
-
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1
-
1
-
-
3
-
-
-
-
-
-
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-
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37107
Hare
Characterization of extracellu ...
Vibrio alginolyticus
J. Gen. Microbiol.
129
1141-1147
1983
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-
-
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1
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1
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2
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-
-
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-
-
-
-
-
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-
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-
-
-
-
-
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-
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1
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1
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-
-
2
-
-
-
-
-
-
-
-
-
-
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-
-
-
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37089
Peterkofsky
-
Bacterial collagenases ...
Hathewaya histolytica, Vibrio sp., Vibrio sp. B-30
Methods Enzymol.
82
453-471
1982
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-
-
-
-
-
-
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3
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4
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1
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1
16
-
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-
-
-
-
-
-
-
-
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-
-
-
-
-
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-
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3
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1
-
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1
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
37098
Emoed
Chemical characterization of t ...
Hathewaya histolytica
Biochim. Biophys. Acta
659
283-291
1981
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-
-
-
-
-
-
-
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1
1
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5
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1
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1
1
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2
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-
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-
-
-
-
-
-
-
-
-
-
-
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1
1
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1
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1
1
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2
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-
-
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-
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37104
Merkel
Purification and characterizat ...
Vibrio sp., Vibrio sp. B-30
Biochemistry
17
2857-2863
1978
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-
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1
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3
2
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6
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1
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1
1
1
4
1
1
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1
-
1
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-
-
-
-
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-
-
-
-
1
-
-
-
-
3
2
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1
-
1
1
1
4
1
1
-
-
-
1
-
1
-
-
-
-
-
-
-
81585
Emd
Five Sepharose-bound ligands f ...
Hathewaya histolytica
FEBS Lett.
77
51-56
1977
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-
-
-
-
-
-
-
-
-
-
1
-
1
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-
1
-
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
37099
Lwebuga-Mukasa
Collagenase enzymes from Clost ...
Hathewaya histolytica
Biochemistry
15
4736-4741
1976
-
-
-
-
-
-
-
-
-
-
2
1
-
3
-
-
1
-
-
-
-
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
1
-
-
-
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
37088
Appel
-
Kollagenasen ...
Clostridium capitorale, Clostridium perfringens, Clostridium welchii, Hathewaya histolytica, Mycobacterium tuberculosis, Pseudomonas aeruginosa
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
1
1098-1104
1974
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-
-
-
-
-
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6
-
6
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12
-
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6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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6
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-
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-
-
-
-
-
12
-
-
-
-
-
6
-
-
-
-
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-
-
37101
Hanada
-
The isolation of collagenase a ...
Pseudoalteromonas mariniglutinosa
Agric. Biol. Chem.
37
1771-1781
1973
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1
4
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6
1
1
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1
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1
1
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1
1
-
3
-
1
-
2
-
1
1
1
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
6
1
1
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1
1
-
1
1
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3
-
1
-
2
-
1
1
1
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-
-
-
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-
-
661875
Diener
In vivo studies with collagena ...
Pseudomonas aeruginosa
Infect. Immun.
7
212-217
1973
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-
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-
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1
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1
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1
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1
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1
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37094
Soru
Clostridium histolyticum colla ...
Hathewaya histolytica
Enzymologia
43
45-55
1972
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-
-
-
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1
2
1
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1
1
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2
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1
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4
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4
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1
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1
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2
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1
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1
1
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1
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4
-
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4
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1
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37095
Soru
Purification by molecular siev ...
Hathewaya histolytica
Enzymologia
39
33-48
1970
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-
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7
1
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2
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1
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4
1
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7
1
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1
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4
1
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37090
Kono
Purification and partial chara ...
Hathewaya histolytica
Biochemistry
7
1106-1114
1968
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1
1
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1
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1
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1
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5
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1
1
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1
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1
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5
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37092
Mandl
Multiplicity of Clostridium hi ...
Hathewaya histolytica
Biochemistry
3
1737-1741
1964
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1
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1
1
1
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1
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5
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1
1
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1
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1
1
1
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5
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1
1
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37102
Gibbons
Degradation of collagenous sub ...
Prevotella melaninogenica
J. Bacteriol.
81
614-621
1961
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1
1
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1
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1
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4
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1
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1
1
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1
1
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1
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1
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1
4
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1
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1
1
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