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Literature summary for 3.4.24.3 extracted from

  • Scozzafava, A.; Supuran, C.T.
    Protease inhibitors. Part 8. Synthesis of potent Clostridium histolyticum collagenase inhibitors incorporating sulfonylated L-alanine hydroxamate moieties (2000), Bioorg. Med. Chem., 8, 637-645.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
-
Hathewaya histolytica
3-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
-
Hathewaya histolytica
4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
-
Hathewaya histolytica
4-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-(dimethylsulfamoyl)-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-(methylsulfonyl)-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-(naphthalen-1-ylcarbamoyl)-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-(naphthalen-1-ylsulfonyl)-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-(naphthalen-2-ylsulfonyl)-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-(phenylsulfonyl)-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(2,4,6-trimethylphenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(2,4-difluorophenyl)carbamoyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(2,4-dinitrophenyl)sulfanyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(2,5-dichlorophenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfanyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(3,4-dichlorophenyl)carbamoyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(3-chloro-4-nitrophenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(3-chlorophenyl)carbamoyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(3-nitrophenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(4-bromophenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)carbamoyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)carbamoyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(4-iodophenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(4-methylphenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfanyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(heptadecafluorooctyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(nonafluorobutyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(trichloromethyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[(trifluoromethyl)sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[[(2-methylphenyl)sulfonyl]carbamoyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[[(4-chlorophenyl)sulfonyl]carbamoyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[[(4-fluorophenyl)sulfonyl]carbamoyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(2-chlorobenzyl)-N-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-L-alanine
-
Hathewaya histolytica
N-(benzylsulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
Hathewaya histolytica
N-([(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]amino]methyl)benzamide
-
Hathewaya histolytica
N-([3-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
Hathewaya histolytica
N-([3-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
Hathewaya histolytica
N-([4-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
Hathewaya histolytica
N-[[4-(acetylamino)phenyl]sulfonyl]-N-(2-chlorobenzyl)-L-alanine
-
Hathewaya histolytica
N2(2-chlorobenzyl)-N-hydroxy-N2-[(trifluoromethyl)sulfonyl]-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylcarbamoyl)-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylsulfonyl)-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-2-ylsulfonyl)-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-(quinolin-8-ylsulfonyl)-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-(thiophen-2-ylsulfonyl)-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4,6-trimethylphenyl)sulfonyl]-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4-dinitrophenyl)sulfanyl]-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-nitrophenyl)sulfanyl]-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(nonafluorobutyl)sulfonyl]-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(trichloromethyl)sulfonyl]-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N-hydroxy-N2-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-(dimethylsulfamoyl)-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(2,4-difluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(2,5-dichlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(2-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(3,4-dichlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(3-chloro-4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(3-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(3-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(4-bromophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(4-iodophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(4-methylphenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[(heptadecafluorooctyl)sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[[(2-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[[(4-chlorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[[(4-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(2-chlorobenzyl)-N2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-(benzylsulfonyl)-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
N2-chlorobenzyl)-N-hydroxy-N2-(methylsulfonyl)-L-alaninamide
-
Hathewaya histolytica
N2-[[4-(acetylamino)phenyl]sulfonyl]-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
-
Hathewaya histolytica
tert-butyl (3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
-
Hathewaya histolytica
tert-butyl (4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
-
Hathewaya histolytica
tert-butyl (5-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]-2-methoxyphenyl)carbamate
-
Hathewaya histolytica

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc metallopeptidase Hathewaya histolytica

Organism

Organism UniProt Comment Textmining
Hathewaya histolytica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O triple helical collagen Hathewaya histolytica ?
-
?
furanacryloyl-Leu-Gly-Pro-Ala + H2O
-
Hathewaya histolytica furanacryloyl-Leu + Gly-Pro-Ala
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000005
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000006
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000006
-
N-([(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]amino]methyl)benzamide pH 7.5, 25°C Hathewaya histolytica
0.000007
-
4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid pH 7.5, 25°C Hathewaya histolytica
0.000007
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(quinolin-8-ylsulfonyl)-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000008
-
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000008
-
N2-(2-chlorobenzyl)-N2-[(heptadecafluorooctyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000008
-
tert-butyl (3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate pH 7.5, 25°C Hathewaya histolytica
0.000008
-
tert-butyl (5-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]-2-methoxyphenyl)carbamate pH 7.5, 25°C Hathewaya histolytica
0.000008
-
3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid pH 7.5, 25°C Hathewaya histolytica
0.000008
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylsulfonyl)-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000009
-
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000009
-
tert-butyl (4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate pH 7.5, 25°C Hathewaya histolytica
0.000009
-
N2-(2-chlorobenzyl)-N2-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000009
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-2-ylsulfonyl)-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.00001
-
N2-(2-chlorobenzyl)-N2-[(3-chloro-4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.00001
-
N2-(2-chlorobenzyl)-N2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.00001
-
N2-(2-chlorobenzyl)-N2-[[(4-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000011
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(nonafluorobutyl)sulfonyl]-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000011
-
N2-(2-chlorobenzyl)-N2-[(3-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000011
-
N2-[[4-(acetylamino)phenyl]sulfonyl]-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000011
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(thiophen-2-ylsulfonyl)-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000011
-
N2-(2-chlorobenzyl)-N2-[[(4-chlorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000011
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylcarbamoyl)-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000011
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4-dinitrophenyl)sulfanyl]-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000013
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-nitrophenyl)sulfanyl]-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000014
-
N2-(2-chlorobenzyl)-N2-[(2,4-difluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000015
-
N2-(2-chlorobenzyl)-N2-[(4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000015
-
N2-(2-chlorobenzyl)-N2-[(2,5-dichlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000015
-
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000015
-
N2-(2-chlorobenzyl)-N2-[(3,4-dichlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000016
-
N2-(2-chlorobenzyl)-N2-[(2-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000017
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4,6-trimethylphenyl)sulfonyl]-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000017
-
N2-(2-chlorobenzyl)-N2-[(3-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000018
-
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000022
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.00003
-
N2-(2-chlorobenzyl)-N2-[(4-iodophenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000033
-
N2-(2-chlorobenzyl)-N2-[(4-bromophenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000035
-
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000036
-
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000045
-
N2-(2-chlorobenzyl)-N2-[(4-methylphenyl)sulfonyl]-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000054
-
N2-(benzylsulfonyl)-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000058
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000071
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(trichloromethyl)sulfonyl]-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000076
-
N2(2-chlorobenzyl)-N-hydroxy-N2-[(trifluoromethyl)sulfonyl]-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000077
-
N2-(2-chlorobenzyl)-N2-(dimethylsulfamoyl)-N-hydroxy-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.000092
-
N2-chlorobenzyl)-N-hydroxy-N2-(methylsulfonyl)-L-alaninamide pH 7.5, 25°C Hathewaya histolytica
0.0004
-
N-(2-chlorobenzyl)-N-(phenylsulfonyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0005
-
N-(2-chlorobenzyl)-N-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0015
-
N-(2-chlorobenzyl)-N-[(heptadecafluorooctyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0015
-
N-(2-chlorobenzyl)-N-(naphthalen-2-ylsulfonyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0016
-
N-(2-chlorobenzyl)-N-(naphthalen-1-ylsulfonyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.002
-
N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0021
-
N-(2-chlorobenzyl)-N-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0024
-
N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0024
-
N-([3-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0024
-
N-(2-chlorobenzyl)-N-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0027
-
N-([4-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.003
-
N-(2-chlorobenzyl)-N-[(nonafluorobutyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.003
-
N-[[4-(acetylamino)phenyl]sulfonyl]-N-(2-chlorobenzyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.003
-
N-([3-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0031
-
N-(2-chlorobenzyl)-N-[(3-chloro-4-nitrophenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0033
-
N-(2-chlorobenzyl)-N-[(trifluoromethyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0034
-
N-(2-chlorobenzyl)-N-[[(4-chlorophenyl)sulfonyl]carbamoyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0036
-
N-(2-chlorobenzyl)-N-[[(4-fluorophenyl)sulfonyl]carbamoyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0038
-
4-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid pH 7.5, 25°C Hathewaya histolytica
0.004
-
N-(2-chlorobenzyl)-N-[[(2-methylphenyl)sulfonyl]carbamoyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0041
-
N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0041
-
N-(2-chlorobenzyl)-N-[(2,5-dichlorophenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0041
-
3-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid pH 7.5, 25°C Hathewaya histolytica
0.0049
-
N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.005
-
N-(2-chlorobenzyl)-N-[(3-nitrophenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.005
-
N-(2-chlorobenzyl)-N-(naphthalen-1-ylcarbamoyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0051
-
N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0052
-
N-(2-chlorobenzyl)-N-[(trichloromethyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0055
-
N-(2-chlorobenzyl)-N-[(2,4-difluorophenyl)carbamoyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0058
-
N-(2-chlorobenzyl)-N-[(3,4-dichlorophenyl)carbamoyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.006
-
N-(2-chlorobenzyl)-N-[(4-methoxyphenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0068
-
N-(2-chlorobenzyl)-N-[(2,4,6-trimethylphenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0068
-
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)carbamoyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0074
-
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)carbamoyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.0076
-
N-(2-chlorobenzyl)-N-[(3-chlorophenyl)carbamoyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.01
-
N-(2-chlorobenzyl)-N-[(4-bromophenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.01
-
N-(2-chlorobenzyl)-N-[(4-iodophenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.012
-
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.013
-
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.016
-
N-(benzylsulfonyl)-N-(2-chlorobenzyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.018
-
N-(2-chlorobenzyl)-N-[(4-methylphenyl)sulfonyl]-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.021
-
N-(2-chlorobenzyl)-N-(methylsulfonyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.024
-
N-(2-chlorobenzyl)-N-(phenylsulfonyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica
0.04
-
N-(2-chlorobenzyl)-N-(dimethylsulfamoyl)-L-alanine pH 7.5, 25°C Hathewaya histolytica