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Literature summary for 3.4.24.3 extracted from

  • Rennert, B.; Melzig, M.F.
    Free fatty acids inhibit the activity of Clostridium histolyticum collagenase and human neutrophil elastase (2002), Planta Med., 68, 767-769.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
erucic acid IC50: 0.415 mM Hathewaya histolytica
heptadecanoic acid IC50: 0.03 mM Hathewaya histolytica
linoleic acid IC50: 0.375 mM Hathewaya histolytica
linolenic acid IC50: 0.46 mM Hathewaya histolytica
additional information no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid Hathewaya histolytica
myristic acid IC50: 0.27 mM Hathewaya histolytica
nonadecanoic acid 0.045 mM Hathewaya histolytica
oleic acid IC50: 0.46 mM Hathewaya histolytica
palmitic acid IC50: 0.035 mM Hathewaya histolytica
palmitoleic acid IC50: 0.405 mM Hathewaya histolytica
pentadecanoic acid IC50: 0.125 mM Hathewaya histolytica
stearic acid IC50: 0.03 mM Hathewaya histolytica

Organism

Organism UniProt Comment Textmining
Hathewaya histolytica
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.03
-
IC50: 0.03 mM Hathewaya histolytica stearic acid
0.03
-
IC50: 0.03 mM Hathewaya histolytica heptadecanoic acid
0.035
-
IC50: 0.035 mM Hathewaya histolytica cabozantinib
0.125
-
IC50: 0.125 mM Hathewaya histolytica pentadecanoic acid
0.27
-
IC50: 0.27 mM Hathewaya histolytica myristic acid
0.375
-
IC50: 0.375 mM Hathewaya histolytica linoleic acid
0.405
-
IC50: 0.405 mM Hathewaya histolytica palmitoleic acid
0.415
-
IC50: 0.415 mM Hathewaya histolytica erucic acid
0.46
-
IC50: 0.46 mM Hathewaya histolytica oleic acid
0.46
-
IC50: 0.46 mM Hathewaya histolytica linolenic acid
0.5
-
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid Hathewaya histolytica additional information