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Information on EC 3.2.1.62 - glycosylceramidase

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EC Tree
IUBMB Comments
The enzyme, found in the intestinal mucosa, hydrolyses beta-D-glucosyl and beta-D-galactosyl residues from a very broad range of substrates using a retaining mechanism. Characterized substrates include glucosyl- and galactosyl-ceramides , O3-, O4'- and O7-glucosylated flavonoids , and the 2'-O-glucosylated dihydrochalcone phlorizin . The enzyme includes two glycosyl hydrolase domains, both belonging to the GH1 family. While one domain is responsible for the activity described here, the other catalyses the reaction of EC 3.2.1.108, lactase [4,5]. cf. EC 3.2.1.45, glucosylceramidase and EC 3.2.1.46, galactosylceramidase.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
lactase-phlorizin hydrolase, phlorizin hydrolase, endoglycoceramidase ii, cerebrosidase, glycosylceramidase, egcrp1, egcii, endoglycoceramidase-related protein 1, endo-glycoceramidase ii, phloretin-glucosidase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a beta-D-galactosyl-N-acylsphingosine + H2O = a ceramide + beta-D-galactose
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(2)
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a beta-D-glucosyl-N-acylsphingosine + H2O = a ceramide + beta-D-glucose
show the reaction diagram
a flavonoid-O-beta-D-glucoside + H2O = a flavonoid + beta-D-glucose
show the reaction diagram
(3)
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PATHWAY SOURCE
PATHWAYS
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