Ligand glucosylceramide

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Basic Ligand Information

Molecular Structure
Picture of glucosylceramide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C28H52NO8R
glucosylceramide
Synonyms:
a beta-D-glucosyl-N-acylsphingosine, a cerebroside, a D-glucosyl-N-acylsphingosine, a glucosylceramide, beta-D-glucocerebroside, beta-D-glucosyl-(1<->1)-ceramide, beta-glucosylceramide, cerebroside, cerebrosides, D-glucocerebroside, D-glucosyl-N-acylsphingosine, D-glucosyl-sphingosine, D-glucosylsphingosine, Glc-Cer, glucocerebroside, glucosyl ceramide, glucosylsphingosine, monohexosylceramide
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glucosyl ceramide + H2O = sphingosine + fatty acid + beta-D-glucose
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-palmitoyl-D-glucosylsphingosine + H2O = palmitic acid + D-glucosylsphingosine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
monohexosylceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = 2'-hydroxymonohexosylceramide + 2 ferricytochrome b5 + H2O
show the reaction diagram
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CMP-N-acetylneuraminate + glucosylceramide = CMP + ?
show the reaction diagram
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glucosylceramide + H2O = D-glucose + ceramide
show the reaction diagram
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glucosylceramide + H2O = ?
show the reaction diagram
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glucosyl ceramide + H2O = sphingosine + fatty acid + beta-D-glucose
show the reaction diagram
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glucosylceramide + H2O = ?
show the reaction diagram
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cerebrosides + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDPglucose + 2-(2-hydroxyacyl)sphingosine = glucocerebroside + UDP
show the reaction diagram
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cerebroside 3-sulfate + H2O = cerebroside + sulfate
show the reaction diagram
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gangliotetraosylceramide + H2O = glucosylceramide
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition or activation depends on substrate
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition or activation depends on substrate
-
bovine brain cerebroside
-
psychosine
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from brain, competitive inhibition of lactase activity, Ki: 1.11 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (17 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.11
-
from brain, competitive inhibition of lactase activity

References & Links

Links to other databases for glucosylceramide

ChEBI
PubChem
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