BRENDA - Enzyme Database
show all sequences of 3.2.1.62

Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase

Hayashi, Y.; Okino, N.; Kakuta, Y.; Shikanai, T.; Tani, M.; Narimatsu, H.; Ito, M.; J. Biol. Chem. 282, 30889-30900 (2007)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
sodium cholate
increases the solubility of the substrates
Homo sapiens
Cloned(Commentary)
Cloned (Commentary)
Organism
expression in Chinese hamster ovary-derived cells expressing polyoma LT antigen
Mus musculus
expression in Chinese hamster ovary-derived cells expressing polyoma LT antigen, in HEK293 cells cotransfected with in KlrP siRNA, overexpression in Escherichia coli
Homo sapiens
Crystallization (Commentary)
Crystallization (Commentary)
Organism
of the recombinant protein with the hanging drops by vapor diffusion method
Homo sapiens
Engineering
Protein Variants
Commentary
Organism
E165D
reduced activity
Homo sapiens
E165Q
almost no activity
Homo sapiens
E373D
reduced activity
Homo sapiens
E373Q
almost no activity
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
conduritol B epoxide only slightly inhibitory
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.04
-
C6-4-nitrobenzo-2-oxa-1,3-diazole-galctosylceramide
-
Homo sapiens
4.64
-
(6-[N-(7-nitrobenz-2-oxa-1,3 diazol-4-yl)amino]hexanoyl)-beta-D-glucosylceramide
-
Homo sapiens
9.24
-
C18-galactosylceramide
-
Homo sapiens
13.67
-
C18-glucosylceramide
-
Homo sapiens
49.28
-
4-methylumbelliferyl-beta-D-glucopyranoside
-
Homo sapiens
144.5
-
4-methylumbelliferyl-beta-D-galactopyranoside
-
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Danio rerio
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Mus musculus
5829
-
cytosol
-
Rattus norvegicus
5829
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
57000
-
SDS-PAGE
Homo sapiens
Organism
Organism
UniProt
Commentary
Textmining
Danio rerio
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Tetraodontidae
-
puffer fish, no activity in Mycetozoa, slime mold
-
Purification (Commentary)
Purification (Commentary)
Organism
of the recombinant protein by a hi-trap chelating HP column and superdex 200 column chromatography
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
embryo
-
Danio rerio
-
fibroblast
-
Homo sapiens
-
liver
-
Mus musculus
-
liver
-
Tetraodontidae
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.00016
-
activity in CHOP cell lysates transformed with cDNA encoding KLPH, with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide as substrate
Mus musculus
0.00025
-
activity in CHOP cell lysates transformed with cDNA encoding KLPH, without conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide as substrate
Mus musculus
0.0005
-
activity in CHOP cell lysates transformed with cDNA encoding KLPH, with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Mus musculus
0.0005
-
in membrane fraction with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Rattus norvegicus
0.00133
-
in cytosolic fraction with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Rattus norvegicus
0.001875
-
activity in CHOP cell lysates transformed with cDNA encoding KlrP, with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Homo sapiens
0.0025
-
activity in CHOP cell lysates transformed with cDNA encoding KLPH, without conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Mus musculus
0.00375
-
activity in CHOP cell lysates transformed with cDNA encoding KlrP, without conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Homo sapiens
0.0052
-
activity in CHOP cell lysates transformed with cDNA encoding KlrP, with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide as substrate
Homo sapiens
0.0066
-
activity in CHOP cell lysates transformed with cDNA encoding KlrP, without conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide as substrate
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
4-methylumbelliferyl-beta-D-galactopyranoside + H2O
-
680835
Homo sapiens
4-methylumbelliferone + D-galactose
-
-
-
?
4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
680835
Homo sapiens
4-methylumbelliferone + D-glucose
-
-
-
?
C18-galactosylceramide + H2O
-
680835
Homo sapiens
C18-ceramide + D-galactose
-
-
-
?
C18-glucosylceramide + H2O
-
680835
Homo sapiens
C18-ceramide + D-glucose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide + H2O
-
680835
Mus musculus
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-galactose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide + H2O
-
680835
Homo sapiens
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-galactose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide + H2O
C6-NBD-glucosylceramide
680835
Mus musculus
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-glucose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide + H2O
C6-NBD-glucosylceramide
680835
Homo sapiens
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-glucose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide + H2O
C6-NBD-glucosylceramide
680835
Rattus norvegicus
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-glucose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide + H2O
C6-NBD-glucosylceramide
680835
Danio rerio
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-glucose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide + H2O
C6-NBD-glucosylceramide
680835
Tetraodontidae
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-glucose
-
-
-
?
galactosylceramide + H2O
-
680835
Homo sapiens
ceramide + D-galactose
-
-
-
?
galactosylsphingosine + H2O
-
680835
Homo sapiens
sphingosine + D-galactose
-
-
-
?
glucosylceramide + H2O
no activity with alpha-galactosylceramide, lactosylceramide, ganglioside M1a and sulfatides
680835
Homo sapiens
ceramide + D-glucose
-
-
-
?
glucosylsphingosine + H2O
-
680835
Homo sapiens
sphingosine + D-glucose
-
-
-
?
glycosyl-N-acylsphingosine + H2O
-
680835
Mus musculus
N-acylsphingosine + a sugar
-
-
-
?
glycosyl-N-acylsphingosine + H2O
-
680835
Danio rerio
N-acylsphingosine + a sugar
-
-
-
?
glycosyl-N-acylsphingosine + H2O
-
680835
Tetraodontidae
N-acylsphingosine + a sugar
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
Gcase
-
Danio rerio
Gcase
-
Homo sapiens
Gcase
-
Rattus norvegicus
Gcase
-
Tetraodontidae
glycosyl-N-acylsphingosine glycohydrolase
-
Danio rerio
glycosyl-N-acylsphingosine glycohydrolase
-
Homo sapiens
glycosyl-N-acylsphingosine glycohydrolase
-
Mus musculus
glycosyl-N-acylsphingosine glycohydrolase
-
Rattus norvegicus
glycosyl-N-acylsphingosine glycohydrolase
-
Tetraodontidae
glycosylceramidase
-
Danio rerio
glycosylceramidase
-
Homo sapiens
glycosylceramidase
-
Mus musculus
glycosylceramidase
-
Rattus norvegicus
glycosylceramidase
-
Tetraodontidae
KLotho lactase phlorizin hydrolase
KLPH
Mus musculus
Klotho-related protein
KlrP, novel cytosolic neutral glycosylceramidase
Danio rerio
Klotho-related protein
KlrP, novel cytosolic neutral glycosylceramidase
Homo sapiens
Klotho-related protein
KlrP, novel cytosolic neutral glycosylceramidase
Rattus norvegicus
Klotho-related protein
KlrP, novel cytosolic neutral glycosylceramidase
Tetraodontidae
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6
7
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Homo sapiens
pH Range
pH Minimum
pH Maximum
Commentary
Organism
5
8
-
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
sodium cholate
increases the solubility of the substrates
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Chinese hamster ovary-derived cells expressing polyoma LT antigen
Mus musculus
expression in Chinese hamster ovary-derived cells expressing polyoma LT antigen, in HEK293 cells cotransfected with in KlrP siRNA, overexpression in Escherichia coli
Homo sapiens
Crystallization (Commentary) (protein specific)
Crystallization
Organism
of the recombinant protein with the hanging drops by vapor diffusion method
Homo sapiens
Engineering (protein specific)
Protein Variants
Commentary
Organism
E165D
reduced activity
Homo sapiens
E165Q
almost no activity
Homo sapiens
E373D
reduced activity
Homo sapiens
E373Q
almost no activity
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
conduritol B epoxide only slightly inhibitory
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.04
-
C6-4-nitrobenzo-2-oxa-1,3-diazole-galctosylceramide
-
Homo sapiens
4.64
-
(6-[N-(7-nitrobenz-2-oxa-1,3 diazol-4-yl)amino]hexanoyl)-beta-D-glucosylceramide
-
Homo sapiens
9.24
-
C18-galactosylceramide
-
Homo sapiens
13.67
-
C18-glucosylceramide
-
Homo sapiens
49.28
-
4-methylumbelliferyl-beta-D-glucopyranoside
-
Homo sapiens
144.5
-
4-methylumbelliferyl-beta-D-galactopyranoside
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Danio rerio
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Mus musculus
5829
-
cytosol
-
Rattus norvegicus
5829
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
57000
-
SDS-PAGE
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
of the recombinant protein by a hi-trap chelating HP column and superdex 200 column chromatography
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
embryo
-
Danio rerio
-
fibroblast
-
Homo sapiens
-
liver
-
Mus musculus
-
liver
-
Tetraodontidae
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.00016
-
activity in CHOP cell lysates transformed with cDNA encoding KLPH, with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide as substrate
Mus musculus
0.00025
-
activity in CHOP cell lysates transformed with cDNA encoding KLPH, without conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide as substrate
Mus musculus
0.0005
-
activity in CHOP cell lysates transformed with cDNA encoding KLPH, with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Mus musculus
0.0005
-
in membrane fraction with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Rattus norvegicus
0.00133
-
in cytosolic fraction with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Rattus norvegicus
0.001875
-
activity in CHOP cell lysates transformed with cDNA encoding KlrP, with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Homo sapiens
0.0025
-
activity in CHOP cell lysates transformed with cDNA encoding KLPH, without conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Mus musculus
0.00375
-
activity in CHOP cell lysates transformed with cDNA encoding KlrP, without conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Homo sapiens
0.0052
-
activity in CHOP cell lysates transformed with cDNA encoding KlrP, with conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide as substrate
Homo sapiens
0.0066
-
activity in CHOP cell lysates transformed with cDNA encoding KlrP, without conduritol B epoxide, C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide as substrate
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
4-methylumbelliferyl-beta-D-galactopyranoside + H2O
-
680835
Homo sapiens
4-methylumbelliferone + D-galactose
-
-
-
?
4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
680835
Homo sapiens
4-methylumbelliferone + D-glucose
-
-
-
?
C18-galactosylceramide + H2O
-
680835
Homo sapiens
C18-ceramide + D-galactose
-
-
-
?
C18-glucosylceramide + H2O
-
680835
Homo sapiens
C18-ceramide + D-glucose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide + H2O
-
680835
Mus musculus
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-galactose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-galactosylceramide + H2O
-
680835
Homo sapiens
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-galactose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide + H2O
C6-NBD-glucosylceramide
680835
Mus musculus
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-glucose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide + H2O
C6-NBD-glucosylceramide
680835
Homo sapiens
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-glucose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide + H2O
C6-NBD-glucosylceramide
680835
Rattus norvegicus
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-glucose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide + H2O
C6-NBD-glucosylceramide
680835
Danio rerio
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-glucose
-
-
-
?
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide + H2O
C6-NBD-glucosylceramide
680835
Tetraodontidae
C6-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + D-glucose
-
-
-
?
galactosylceramide + H2O
-
680835
Homo sapiens
ceramide + D-galactose
-
-
-
?
galactosylsphingosine + H2O
-
680835
Homo sapiens
sphingosine + D-galactose
-
-
-
?
glucosylceramide + H2O
no activity with alpha-galactosylceramide, lactosylceramide, ganglioside M1a and sulfatides
680835
Homo sapiens
ceramide + D-glucose
-
-
-
?
glucosylsphingosine + H2O
-
680835
Homo sapiens
sphingosine + D-glucose
-
-
-
?
glycosyl-N-acylsphingosine + H2O
-
680835
Mus musculus
N-acylsphingosine + a sugar
-
-
-
?
glycosyl-N-acylsphingosine + H2O
-
680835
Danio rerio
N-acylsphingosine + a sugar
-
-
-
?
glycosyl-N-acylsphingosine + H2O
-
680835
Tetraodontidae
N-acylsphingosine + a sugar
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6
7
C6-4-nitrobenzo-2-oxa-1,3-diazole-glucosylceramide as substrate
Homo sapiens
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
5
8
-
Homo sapiens
Other publictions for EC 3.2.1.62
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
749451
Durand
-
A single point mutation alter ...
Rhodococcus sp. M-777
ACS Catal.
6
8264-8275
2016
-
-
1
-
1
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
5
-
2
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
3
-
-
-
-
-
-
-
-
3
3
749905
Ben Bdira
Hydrophobic interactions cont ...
Rhodococcus sp. M777
Biochemistry
55
4823-4835
2016
-
-
1
1
-
-
1
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
1
2
1
-
2
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
1
1
-
2
-
1
-
-
-
-
-
-
-
-
-
750706
Watanabe
Ergosteryl-beta-glucosidase ( ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Glycobiology
25
1079-1089
2015
-
-
1
-
-
-
-
-
-
-
-
-
-
69
-
-
1
-
-
-
-
-
20
1
3
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
20
1
-
-
-
-
1
1
-
-
-
2
2
-
-
-
732073
Ishibashi
Quality control of fungus-spec ...
Cryptococcus neoformans, Cryptococcus neoformans H99
J. Biol. Chem.
287
368-381
2012
1
-
1
-
2
-
14
1
1
1
-
2
1
5
-
-
1
-
-
-
-
-
6
-
3
1
1
-
1
1
-
-
-
-
-
-
1
-
1
-
-
2
-
-
14
-
1
1
1
-
2
1
-
-
1
-
-
-
-
6
-
1
1
-
1
1
-
-
-
-
2
2
-
1
1
715230
Naz
Epigallocatechin-3-gallate inh ...
Rattus norvegicus
J. Agric. Food Chem.
59
2734-2738
2011
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709142
Behrendt
Structural hierarchy of regula ...
Homo sapiens
J. Biol. Chem.
285
4143-4152
2010
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
1
-
-
1
1
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
709206
Koek
The T-13910C polymorphism in t ...
Homo sapiens
J. Bone Miner. Res.
25
1980-1987
2010
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698078
Behrendt
Impaired trafficking and subce ...
Homo sapiens
Gastroenterology
136
2295-2303
2009
-
1
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698508
Willing
Intestinal microbiota differen ...
Sus scrofa
J. Anim. Physiol. Anim. Nutr. (Berl.)
93
586-595
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699936
Tanaka
Higher expression of jejunal L ...
Rattus norvegicus
Life Sci.
83
122-127
2008
1
-
1
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
3
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701338
Cramm-Behrens
Apical cargo traverses endosom ...
Homo sapiens
Traffic
9
2206-2220
2008
1
1
1
-
-
-
1
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677473
Bosse
Gata4 and Hnf1alpha are partia ...
Mus musculus
Am. J. Physiol. Gastrointest. Liver Physiol.
292
G1302-G1314
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679123
Beau
An NSP4-dependant mechanism by ...
Homo sapiens
Cell. Microbiol.
9
2254-2266
2007
-
1
-
-
-
-
1
2
-
-
2
-
-
4
-
-
1
-
-
1
6
-
2
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
2
-
-
-
-
1
-
1
6
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680770
Caines
Structural and mechanistic ana ...
Rhodococcus sp.
J. Biol. Chem.
282
14300-14308
2007
-
-
1
1
2
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
2
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680835
Hayashi
Klotho-related protein is a no ...
Danio rerio, Homo sapiens, Mus musculus, Rattus norvegicus, Tetraodontidae
J. Biol. Chem.
282
30889-30900
2007
1
-
2
1
4
-
1
6
8
-
1
-
-
9
-
-
1
-
-
13
10
-
18
-
19
-
-
-
-
1
1
-
-
-
-
-
1
-
2
-
1
4
-
-
1
-
6
8
-
1
-
-
-
-
1
-
13
10
-
18
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
666149
Mizuma
Kinetic characterization of gl ...
Homo sapiens
J. Pharm. Pharmacol.
57
661-664
2005
-
-
-
-
-
-
-
6
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654552
Day
Absorption of quercetin-3-gluc ...
Rattus norvegicus
Biochem. Pharmacol.
65
1199-1206
2003
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656600
Sesink
Intestinal uptake of quercetin ...
Rattus norvegicus
J. Nutr.
133
773-776
2003
-
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657409
Wilkinson
Hydrolysis by lactase phlorizi ...
Rattus norvegicus
Xenobiotica
33
255-264
2003
-
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656061
Mackey
Enzymatic hydrolysis of pyrido ...
Rattus norvegicus
J. Biol. Chem.
277
26858-26864
2002
-
-
-
-
-
-
5
2
1
-
-
-
-
2
-
1
1
-
-
1
-
-
2
1
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
5
2
2
1
-
-
-
-
-
1
1
-
1
-
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
656110
Jacob
Prosequence of human lactase-p ...
Homo sapiens
J. Biol. Chem.
277
8217-8225
2002
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656599
Burrin
Oral IGF-I alters the posttran ...
Sus scrofa
J. Nutr.
131
2235-2241
2001
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208743
Day
Dietary flavonoids and isoflav ...
Ovis aries, Ovis aries aries
FEBS Lett.
468
166-170
2000
-
-
-
-
-
-
2
12
1
-
-
3
-
3
-
-
1
1
-
2
-
-
14
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
12
1
-
-
3
-
-
-
1
-
2
-
-
14
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
208744
Jacob
Additional N-glycosylation and ...
Homo sapiens
J. Biol. Chem.
275
10630-10637
2000
-
-
1
-
3
-
-
-
1
-
-
1
-
1
-
1
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655412
Arribas
Differential mechanism-based l ...
Ovis aries
Eur. J. Biochem.
267
6996-7005
2000
-
-
-
-
-
-
4
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208745
Wuthrich
Human lactase-phloizin hydrola ...
Homo sapiens
FEBS Lett.
405
321-327
1997
-
-
1
-
-
-
-
-
3
-
2
1
-
2
-
1
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
2
1
-
-
1
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208746
Estrada
Quantitative analysis of lacta ...
Rattus sp.
J. Cell. Physiol.
167
341-348
1996
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208747
Naim
The pro-region of human intest ...
Homo sapiens
Biol. Chem. Hoppe-Seyler
376
255-258
1995
-
-
1
-
-
-
-
-
-
-
2
1
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208748
Naim
Processing and transport of hu ...
Homo sapiens
FEBS Lett.
342
302-307
1994
-
-
-
-
-
-
-
-
1
-
1
1
-
2
-
1
-
-
-
3
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
1
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208749
Naim
Impact of O-glycosylation on t ...
Homo sapiens
J. Biol. Chem.
267
25494-25504
1992
-
-
-
-
-
-
-
1
-
-
2
1
-
3
-
1
1
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
1
-
-
1
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208750
Wacker
Location of the two catalytic ...
Oryctolagus cuniculus
J. Biol. Chem.
267
18744-18752
1992
-
-
-
-
-
-
3
-
3
-
1
3
-
2
-
-
1
-
-
1
1
-
4
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
3
2
-
3
-
1
3
-
-
-
1
-
1
1
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208751
Mantei
Complete primary structure of ...
Homo sapiens, Oryctolagus cuniculus
EMBO J.
7
2705-2713
1988
-
-
-
-
-
-
-
-
4
-
-
2
-
4
-
-
1
-
-
2
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
1
-
2
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208752
Buller
Biosynthesis, glycosylation, a ...
Rattus sp.
J. Biol. Chem.
262
17206-17211
1987
-
-
-
-
-
-
-
-
3
-
2
-
-
3
-
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-
208753
Naim
Biosynthesis and maturation of ...
Homo sapiens
Biochem. J.
241
427-434
1987
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
1
-
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-
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208754
Danielsen
Biosynthesis of intestinal mic ...
Sus scrofa
Biochem. Biophys. Res. Commun.
122
82-90
1984
-
-
-
-
-
-
-
-
1
-
2
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2
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208755
Skovbjerg
Evidence for biosynthesis of l ...
Homo sapiens
Biochim. Biophys. Acta
798
247-251
1984
-
-
-
-
-
-
-
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2
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2
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-
-
-
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208757
Skovbjerg
Further characterization of in ...
Homo sapiens, Sus scrofa
Biochim. Biophys. Acta
707
89-97
1982
-
-
-
-
-
-
4
1
2
-
3
16
-
2
-
-
1
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2
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26
2
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1
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4
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16
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26
2
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1
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1
-
1
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-
-
-
-
-
-
208756
Skovbjerg
Purification and characterizat ...
Homo sapiens
Eur. J. Biochem.
114
653-661
1981
-
-
-
-
-
1
2
3
1
-
3
4
-
1
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1
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1
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1
-
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-
-
-
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208758
Kobayashi
The glycosylceramidase in the ...
Mus musculus
J. Biol. Chem.
256
7768-7773
1981
1
-
-
-
-
-
-
17
-
-
1
12
-
4
-
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3
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18
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17
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12
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3
3
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18
-
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1
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208759
Cousineau
Isolation and characterization ...
Rattus sp.
Biochim. Biophys. Acta
615
147-157
1980
-
-
-
-
-
-
-
4
1
-
-
2
-
2
-
-
1
-
-
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1
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4
1
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1
-
2
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1
-
1
-
-
-
-
-
-
-
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-
208760
Ramaswamy
Lactase-phlorizin hydrolase co ...
Macaca radiata
Biochim. Biophys. Acta
403
446-455
1975
-
-
-
-
-
-
3
2
-
-
-
6
-
2
-
-
1
-
-
2
2
-
12
-
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1
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1
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1
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3
1
2
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6
-
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1
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2
2
-
12
-
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-
1
-
1
-
-
-
-
-
-
-
-
-
208761
Birkenmeier
Enzymatic properties of rat la ...
Rattus sp.
Biochim. Biophys. Acta
350
100-112
1974
-
-
-
-
-
1
-
1
1
-
-
5
-
2
-
1
1
-
-
1
-
1
8
-
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5
-
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-
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8
-
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-
-
-
-
-
-
-
-
-
-
-
-
208762
Leese
On the identity between the sm ...
Rattus sp.
J. Biol. Chem.
248
8170-8173
1973
-
-
-
-
-
-
4
2
-
-
-
4
-
1
-
-
1
-
-
1
1
-
15
-
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1
-
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4
-
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4
-
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-
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1
-
15
-
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1
-
1
-
-
-
-
-
-
-
-
-
208763
Hamaswamy
Lactase-phlorizin hydrolase co ...
Macaca radiata
Biochem. Biophys. Res. Commun.
54
197-204
1973
6
-
-
-
-
-
7
-
-
-
-
2
-
2
-
-
1
-
-
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-
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6
-
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-
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1
-
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-
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-
-
-
-
-
-
-
-
-
208764
Kraml
beta-Glucosidase (phlorizin hy ...
Rattus sp.
Biochim. Biophys. Acta
258
520-530
1972
-
-
-
-
-
-
4
7
1
-
-
3
-
1
-
-
1
-
-
1
-
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7
-
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-
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-
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-
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1
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-
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1
-
-
7
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
208765
Malathi
Phlorizin hydrolase: A beta-gl ...
Cricetinae
Biochim. Biophys. Acta
173
245-256
1969
-
-
-
-
-
-
2
1
2
-
-
1
-
1
-
-
-
-
-
1
-
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1
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