BRENDA - Enzyme Database
show all sequences of 3.2.1.62

Enzymatic hydrolysis of pyridoxine-5'-beta-D-glucoside is catalyzed by intestinal lactase-phlorizin hydrolase

Mackey, A.D.; Henderson, G.N.; Gregory, J.F., 3rd; J. Biol. Chem. 277, 26858-26864 (2002)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
cellobiose
-
Rattus norvegicus
D-glucose
-
Rattus norvegicus
lactose
competitive to pyridoxine-5'-beta-D-glucoside
Rattus norvegicus
additional information
not inhibitory: pyridoxine, 2’,4’-dinitrophenyl-2-fluoro-2-deoxy-beta-D-glucopyranoside
Rattus norvegicus
pyridoxine-5'-beta-D-glucoside
substrate inhibition above 3 mM
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1
-
pyridoxine-5'-beta-D-glucoside
pH 6.0, 37°C
Rattus norvegicus
16
-
lactose
pH 6.0, 37°C
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Rattus norvegicus
16020
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
proteolytic modification
precursor form of 200000-220000 Da
Rattus norvegicus
Purification (Commentary)
Commentary
Organism
-
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
small intestine
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
lactose + H2O
-
656061
Rattus norvegicus
?
-
-
-
?
pyridoxine-5'-beta-D-glucoside + H2O
-
656061
Rattus norvegicus
pyridoxine + D-glucose
-
-
-
r
Subunits
Subunits
Commentary
Organism
?
x * 135000-140000, SDS-PAGE, mature protein
Rattus norvegicus
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1
-
pyridoxine-5'-beta-D-glucoside
pH 6.0, 37°C
Rattus norvegicus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
56
-
lactose
pH 6.0, 37°C
Rattus norvegicus
64
-
D-glucose
pH 6.0, 37°C
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
cellobiose
-
Rattus norvegicus
D-glucose
-
Rattus norvegicus
lactose
competitive to pyridoxine-5'-beta-D-glucoside
Rattus norvegicus
additional information
not inhibitory: pyridoxine, 2’,4’-dinitrophenyl-2-fluoro-2-deoxy-beta-D-glucopyranoside
Rattus norvegicus
pyridoxine-5'-beta-D-glucoside
substrate inhibition above 3 mM
Rattus norvegicus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
56
-
lactose
pH 6.0, 37°C
Rattus norvegicus
64
-
D-glucose
pH 6.0, 37°C
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1
-
pyridoxine-5'-beta-D-glucoside
pH 6.0, 37°C
Rattus norvegicus
16
-
lactose
pH 6.0, 37°C
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Rattus norvegicus
16020
-
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
proteolytic modification
precursor form of 200000-220000 Da
Rattus norvegicus
Purification (Commentary) (protein specific)
Commentary
Organism
-
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
small intestine
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
lactose + H2O
-
656061
Rattus norvegicus
?
-
-
-
?
pyridoxine-5'-beta-D-glucoside + H2O
-
656061
Rattus norvegicus
pyridoxine + D-glucose
-
-
-
r
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 135000-140000, SDS-PAGE, mature protein
Rattus norvegicus
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1
-
pyridoxine-5'-beta-D-glucoside
pH 6.0, 37°C
Rattus norvegicus
Other publictions for EC 3.2.1.62
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
749451
Durand
-
A single point mutation alter ...
Rhodococcus sp. M-777
ACS Catal.
6
8264-8275
2016
-
-
1
-
1
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
5
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
3
-
-
-
-
-
-
-
-
3
3
749905
Ben Bdira
Hydrophobic interactions cont ...
Rhodococcus sp. M777
Biochemistry
55
4823-4835
2016
-
-
1
1
-
-
1
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
1
1
-
2
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
1
1
-
2
-
1
-
-
-
-
-
-
-
-
-
750706
Watanabe
Ergosteryl-beta-glucosidase ( ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Glycobiology
25
1079-1089
2015
-
-
1
-
-
-
-
-
-
-
-
-
-
62
-
-
1
-
-
-
-
-
20
1
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
20
1
-
-
-
-
1
1
-
-
-
2
2
-
-
-
732073
Ishibashi
Quality control of fungus-spec ...
Cryptococcus neoformans, Cryptococcus neoformans H99
J. Biol. Chem.
287
368-381
2012
1
-
1
-
2
-
14
1
1
1
-
2
1
5
-
-
1
-
-
-
-
-
6
-
1
1
-
1
1
-
-
-
-
-
-
1
-
1
-
-
2
-
-
14
-
1
1
1
-
2
1
-
-
1
-
-
-
-
6
-
1
1
-
1
1
-
-
-
-
2
2
-
1
1
715230
Naz
Epigallocatechin-3-gallate inh ...
Rattus norvegicus
J. Agric. Food Chem.
59
2734-2738
2011
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709142
Behrendt
Structural hierarchy of regula ...
Homo sapiens
J. Biol. Chem.
285
4143-4152
2010
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
1
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
709206
Koek
The T-13910C polymorphism in t ...
Homo sapiens
J. Bone Miner. Res.
25
1980-1987
2010
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698078
Behrendt
Impaired trafficking and subce ...
Homo sapiens
Gastroenterology
136
2295-2303
2009
-
1
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
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-
-
1
1
-
-
2
-
-
-
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-
-
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-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698508
Willing
Intestinal microbiota differen ...
Sus scrofa
J. Anim. Physiol. Anim. Nutr. (Berl.)
93
586-595
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
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1
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-
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699936
Tanaka
Higher expression of jejunal L ...
Rattus norvegicus
Life Sci.
83
122-127
2008
1
-
1
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701338
Cramm-Behrens
Apical cargo traverses endosom ...
Homo sapiens
Traffic
9
2206-2220
2008
1
1
1
-
-
-
1
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
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1
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1
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677473
Bosse
Gata4 and Hnf1alpha are partia ...
Mus musculus
Am. J. Physiol. Gastrointest. Liver Physiol.
292
G1302-G1314
2007
-
1
-
-
-
-
-
-
-
-
-
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3
-
-
-
-
-
2
-
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1
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1
-
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-
-
-
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-
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-
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-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679123
Beau
An NSP4-dependant mechanism by ...
Homo sapiens
Cell. Microbiol.
9
2254-2266
2007
-
1
-
-
-
-
1
2
-
-
2
-
-
4
-
-
1
-
-
1
6
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
2
-
-
-
-
1
-
1
6
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680770
Caines
Structural and mechanistic ana ...
Rhodococcus sp.
J. Biol. Chem.
282
14300-14308
2007
-
-
1
1
2
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
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1
-
1
2
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-
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2
-
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-
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1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680835
Hayashi
Klotho-related protein is a no ...
Danio rerio, Homo sapiens, Mus musculus, Rattus norvegicus, Tetraodontidae
J. Biol. Chem.
282
30889-30900
2007
1
-
2
1
4
-
1
6
8
-
1
-
-
9
-
-
1
-
-
13
10
-
18
-
-
-
-
-
1
1
-
-
-
-
-
1
-
2
-
1
4
-
-
1
-
6
8
-
1
-
-
-
-
1
-
13
10
-
18
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
666149
Mizuma
Kinetic characterization of gl ...
Homo sapiens
J. Pharm. Pharmacol.
57
661-664
2005
-
-
-
-
-
-
-
6
-
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-
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1
-
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-
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1
-
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3
-
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-
-
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6
-
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1
-
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3
-
-
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654552
Day
Absorption of quercetin-3-gluc ...
Rattus norvegicus
Biochem. Pharmacol.
65
1199-1206
2003
-
1
-
-
-
-
-
-
-
-
-
1
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1
-
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1
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1
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1
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
656600
Sesink
Intestinal uptake of quercetin ...
Rattus norvegicus
J. Nutr.
133
773-776
2003
-
1
-
-
-
-
1
-
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1
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1
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-
-
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1
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-
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-
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1
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1
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1
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-
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1
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-
-
-
-
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-
-
-
-
657409
Wilkinson
Hydrolysis by lactase phlorizi ...
Rattus norvegicus
Xenobiotica
33
255-264
2003
-
1
-
-
-
-
1
-
-
-
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1
-
1
-
-
-
-
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1
-
-
2
-
-
-
-
-
-
-
-
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1
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-
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1
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1
-
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656061
Mackey
Enzymatic hydrolysis of pyrido ...
Rattus norvegicus
J. Biol. Chem.
277
26858-26864
2002
-
-
-
-
-
-
5
2
1
-
-
-
-
2
-
1
1
-
-
1
-
-
2
1
-
-
-
1
-
-
-
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2
-
-
-
-
-
-
-
-
-
-
5
2
2
1
-
-
-
-
-
1
1
-
1
-
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
656110
Jacob
Prosequence of human lactase-p ...
Homo sapiens
J. Biol. Chem.
277
8217-8225
2002
-
-
-
-
-
-
-
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2
-
2
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2
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14
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Additional N-glycosylation and ...
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Quantitative analysis of lacta ...
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The pro-region of human intest ...
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Processing and transport of hu ...
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Impact of O-glycosylation on t ...
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Complete primary structure of ...
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Biosynthesis and maturation of ...
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7
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Biosynthesis of intestinal mic ...
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Skovbjerg
Evidence for biosynthesis of l ...
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Skovbjerg
Further characterization of in ...
Homo sapiens, Sus scrofa
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1
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1
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1
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4
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1
2
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16
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26
2
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Skovbjerg
Purification and characterizat ...
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1
1
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1
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Kobayashi
The glycosylceramidase in the ...
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1
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17
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1
12
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1
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3
3
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18
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1
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2
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Cousineau
Isolation and characterization ...
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208760
Ramaswamy
Lactase-phlorizin hydrolase co ...
Macaca radiata
Biochim. Biophys. Acta
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1975
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12
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1
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3
1
2
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6
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1
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2
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12
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Birkenmeier
Enzymatic properties of rat la ...
Rattus sp.
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1
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1
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Leese
On the identity between the sm ...
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15
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1
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15
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Hamaswamy
Lactase-phlorizin hydrolase co ...
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Kraml
beta-Glucosidase (phlorizin hy ...
Rattus sp.
Biochim. Biophys. Acta
258
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1972
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7
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7
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Malathi
Phlorizin hydrolase: A beta-gl ...
Cricetinae
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1969
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1
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2
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1
2
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1
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1
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1
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1
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