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histone deacetylase 7 phosphate + H2O
histone deacetylase 7 + phosphate
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
myosin regulatory light-chain phosphate + H2O
myosin regulatory light-chain + phosphate
P-MLC20 + H2O
MLC20 + phosphate
-
P-MLC20: phospho-peptide mimicking MLC20(3-26:P-Ser19)
-
-
?
phosphorylated glycogen synthase + H2O
glycogen synthase + phosphate
phosphorylated heavy meromyosin + H2O
heavy meromyosin + phosphate
phosphorylated myosin + H2O
myosin + phosphate
phosphorylated myosin-light chain kinase + H2O
myosin light-chain kinase + phosphate
phosphorylated phoshorylase A + H2O
phosphorylase A + phosphate
phosphorylated phoshorylase B + H2O
phosphorylase B + phosphate
-
myosin-associated PP-1M
-
?
phosphorylated phosphorylase kinase + H2O
phosphorylase kinase + phosphate
regulatory myosin light-chain phosphate + H2O
regulatory myosin light-chain + phosphate
[myosin light-chain] phosphate + H2O
[myosin light-chain] + phosphate
[myosin regulatory light chain] phosphate + H2O
[myosin regulatory light chain] + phosphate
-
from chicken gizzard
-
-
?
additional information
?
-
histone deacetylase 7 phosphate + H2O

histone deacetylase 7 + phosphate
-
HDAC7, dephosphorylation induces reimport into the nucleus
-
-
?
histone deacetylase 7 phosphate + H2O
histone deacetylase 7 + phosphate
-
HDAC7, dephosphorylation induces reimport into the nucleus
-
-
?
myosin light-chain phosphate + H2O

myosin light-chain + phosphate
-
isozyme PP-1M is more active towards native myosin than isolated myosin P-light-chains or phosphorylase A
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
PP-2A: 30fold more effective in dephosphorylating myosin P-light-chains than native myosin, 10fold more active towards myosin P-light-chains than phosphorylase A
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
muscle
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
muscle
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
muscle
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
38 kDa catalytic subunit PP1c and holoenzyme are active, the 130 kDa subunit M130 activates PP1c activity, effect of truncation mutants of M130 on PP1c activity
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
from bovine stomach
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
the 130 kDa subunit and the 20 kDa subunit enhance activity of the catalytic subunit towards heavy meromyosin or the isolated P-light-chain from smooth muscle
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
role in the variable coupling between force and myosin light chain phosphorylation
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
the 130 kDa subunit and the 20 kDa subunit enhance activity of the catalytic subunit towards heavy meromyosin or the isolated P-light-chain from smooth muscle
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
from smooth muscle
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
important role in regulating myofibroblast contraction, Rho/Rho kinase-mediated inhibition of MLCPPase is necessary for lysophosphatidic acid-promoted myofibroblast contraction, in contrast to smooth muscle cells, in which MLCPPase activity only regulates the sensitivity of the contractile response to Ca2+
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
muscle
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
holoenzyme and isolated catalytic subunit are active
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
SMP-I, -II, -III and -IV are active
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
38 kDa catalytic subunit PP1c and holoenzyme are active, the 130 kDa subunit M130 activates PP1c activity, effect of truncation mutants of M130 on PP1c activity
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
myosin regulatory light chain RLC from chicken gizzard, specificity of MLCP toward various phosphorylation sites of RCL, N-terminal region of RLC plays an important role in substrate recognition
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
reaction is a prerequisite for the actin activation of the myosin Mg2+-ATPase
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
dephosphorylation of the myosin regulatory light chain of myosin, which is phosphorylated at various sites at its N-terminal region
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
myosin regulatory light chain RLC from chicken gizzard, specificity of MLCP toward various phosphorylation sites of RCL, N-terminal region of RLC plays an important role in substrate recognition
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
dephosphorylation of the myosin regulatory light chain of myosin, which is phosphorylated at various sites at its N-terminal region
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
isozyme PP-1M is more active towards native myosin than isolated myosin P-light-chains or phosphorylase A
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
isozyme PP-1G dephosphorylates myosin, myosin P-light-chain and phosphorylase A at comparable rates
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
PP-2A: 30fold more effective in dephosphorylating myosin P-light-chains than native myosin, 10fold more active towards myosin P-light-chains than phosphorylase A
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
plays a critical regulatory role in the Ca2+ sensitivity of myosin phosphorylation and smooth muscle contraction
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
muscle
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
chicken gizzard 20 kDa myosin light-chain phosphate
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
from turkey gizzard
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
key smooth muscle regulatory protein, MLCP is required for muscle relaxation
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
muscle
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
-
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
110 kDa/21 kDa complex accelerates dephosphorylation induced by the catalytic subunit PP1C by 1.6fold, the N-terminal sequence 1-309 of the 110 kDa subunit is sufficient to enhance the PP1C activity in muscle
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
muscle
-
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
20 kDa myosin light chain
-
?
myosin light-chain phosphate + H2O
myosin light-chain + phosphate
-
110 kDa/21 kDa complex accelerates dephosphorylation induced by the catalytic subunit PP1C by 1.6fold, the N-terminal sequence 1-309 of the 110 kDa subunit is sufficient to enhance the PP1C activity in muscle
-
?
myosin regulatory light-chain phosphate + H2O

myosin regulatory light-chain + phosphate
-
nonmuscle
-
-
?
myosin regulatory light-chain phosphate + H2O
myosin regulatory light-chain + phosphate
-
nonmuscle
-
-
?
myosin regulatory light-chain phosphate + H2O
myosin regulatory light-chain + phosphate
-
nonmuscle
-
-
?
phosphorylated glycogen synthase + H2O

glycogen synthase + phosphate
-
the 130 kDa subunit and the 20 kDa subunit suppress activity of the catalytic subunit towards phosphorylase A and glycogen synthase
-
-
?
phosphorylated glycogen synthase + H2O
glycogen synthase + phosphate
-
the 130 kDa subunit and the 20 kDa subunit suppress activity of the catalytic subunit towards phosphorylase A and glycogen synthase
-
-
?
phosphorylated heavy meromyosin + H2O

heavy meromyosin + phosphate
-
the 130 kDa subunit and the 20 kDa subunit enhance activity of the catalytic subunit towards heavy meromyosin or the isolated P-light-chain from smooth muscle
-
-
?
phosphorylated heavy meromyosin + H2O
heavy meromyosin + phosphate
-
the 130 kDa subunit and the 20 kDa subunit enhance activity of the catalytic subunit towards heavy meromyosin or the isolated P-light-chain from smooth muscle
-
-
?
phosphorylated heavy meromyosin + H2O
heavy meromyosin + phosphate
-
a chymotryptic fragment of myosin, only SMP-III and SMP-IV are active, SMP-I and SMP-II not
-
-
?
phosphorylated heavy meromyosin + H2O
heavy meromyosin + phosphate
-
from turkey gizzard
-
-
?
phosphorylated myosin + H2O

myosin + phosphate
-
isoenzyme PP-1M is more active towards native myosin than isolated myosin P-light-chains or phosphorylase A
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
isoenzyme PP-2A: low activity with native myosin
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
-
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
-
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
from bovine stomach, P-myosin assembly is essential for SMMP activity
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
-
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
-
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
-
-
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
-
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
from turkey gizzard
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
catalytic subunit is active, holoenzyme not
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
myosin heavy chain plays a role in the smooth muscle MLCP-myosin regulatory light chain interaction, specificity toward myosin phosphorylated at various sites of the myosin regulatory light chain RLC, role of the N-terminal region of RLC in the dephosphorylation of myosin
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
only SMP-III and SMP-IV are active, SMP-I and SMP-II not
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
dephosphorylates myosin in vivo, dephosphorylation of the myosin regulatory light chain, which is phosphorylated at various sites at its N-terminal region
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
from turkey gizzard
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
myosin heavy chain plays a role in the smooth muscle MLCP-myosin regulatory light chain interaction, specificity toward myosin phosphorylated at various sites of the myosin regulatory light chain RLC, role of the N-terminal region of RLC in the dephosphorylation of myosin
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
dephosphorylates myosin in vivo, dephosphorylation of the myosin regulatory light chain, which is phosphorylated at various sites at its N-terminal region
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
isoenzyme PP-1G dephosphorylates myosin, myosin P-light-chain and phosphorylase A at comparable rates
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
isoenzyme PP-1M is more active towards native myosin than PP-1G
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
isoenzyme PP-1M is more active towards native myosin than isolated myosin P-light-chains or phosphorylase A
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
isoenzyme PP-2A: low activity with native myosin
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
-
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
from turkey gizzard
-
?
phosphorylated myosin + H2O
myosin + phosphate
-
-
-
?
phosphorylated myosin-light chain kinase + H2O

myosin light-chain kinase + phosphate
-
holoenzyme and isolated catalytic subunit are active, phosphorylated at 2 sites, in absence of bound calmodulin rapid dephosphorylation at both sites, in presence of bound calmodulin dephosphorylation of only one site
-
?
phosphorylated myosin-light chain kinase + H2O
myosin light-chain kinase + phosphate
-
autophosphorylated myosin light chain kinase is a good substrate for the kinase- and myosin-associated protein phosphatase KAMPPase
-
-
?
phosphorylated myosin-light chain kinase + H2O
myosin light-chain kinase + phosphate
-
SMP-I modulates the activity of myosin-light chain kinase
-
?
phosphorylated phoshorylase A + H2O

phosphorylase A + phosphate
-
PP-2A: 30fold more effective in dephosphorylating myosin P-light-chains than native myosin, 10fold more active towards myosin P-light-chains than phosphorylase A
-
?
phosphorylated phoshorylase A + H2O
phosphorylase A + phosphate
-
isoenzyme PP-1M is more active towards native myosin than isolated myosin P-light-chains or phosphorylase A
-
?
phosphorylated phoshorylase A + H2O
phosphorylase A + phosphate
-
-
-
?
phosphorylated phoshorylase A + H2O
phosphorylase A + phosphate
-
38 kDa catalytic subunit PP1c
-
?
phosphorylated phoshorylase A + H2O
phosphorylase A + phosphate
-
PP-2A: 30fold more effective in dephosphorylating myosin P-light-chains than native myosin, 10fold more active towards myosin P-light-chains than phosphorylase A
-
?
phosphorylated phoshorylase A + H2O
phosphorylase A + phosphate
-
isoenzyme PP-1M is more active towards native myosin than isolated myosin P-light-chains or phosphorylase A
-
?
phosphorylated phoshorylase A + H2O
phosphorylase A + phosphate
-
isoenzyme PP-1G dephosphorylates myosin, myosin P-light-chains and phosphorylase A at comparable rates
-
?
phosphorylated phosphorylase kinase + H2O

phosphorylase kinase + phosphate
-
the 130 kDa subunit and the 20 kDa subunit suppress activity of the catalytic subunit towards phosphorylase A and glycogen synthase
-
-
?
phosphorylated phosphorylase kinase + H2O
phosphorylase kinase + phosphate
-
the 130 kDa subunit and the 20 kDa subunit suppress activity of the catalytic subunit towards phosphorylase A and glycogen synthase
-
-
?
radixin + H2O

?
-
-
-
-
?
radixin + H2O
?
-
an ERM protein
-
-
?
regulatory myosin light-chain phosphate + H2O

regulatory myosin light-chain + phosphate
-
-
-
-
?
regulatory myosin light-chain phosphate + H2O
regulatory myosin light-chain + phosphate
-
-
-
-
?
[myosin light-chain] phosphate + H2O

[myosin light-chain] + phosphate
-
-
-
-
?
[myosin light-chain] phosphate + H2O
[myosin light-chain] + phosphate
-
-
-
-
?
[myosin light-chain] phosphate + H2O
[myosin light-chain] + phosphate
-
substrate is phosphorylated Physarum myosin II
-
-
?
[myosin light-chain] phosphate + H2O
[myosin light-chain] + phosphate
-
-
-
-
?
[myosin light-chain] phosphate + H2O
[myosin light-chain] + phosphate
-
substrate is regulatory light chain (LC20) of myosin II, MLCP-mediated dephosphorylation of LC20 at Ser19
-
-
?
additional information

?
-
-
both gene products of protein phosphatase 1, PP1, (catalytic subunit of the myosin phosphatase) ppp1cba and ppp1cbb interact with Mypt1 (regulatory subunit of the myosin phosphatase) and assemble an active myosin phosphatase complex
-
-
-
additional information
?
-
-
enzyme binds to vesicles of acidic phospholipids, i.e. phosphatidylserine, phosphatidylinositol and phosphatidic acid, but not to neutral phospholipids, phosphatidylserine binding decreases by increasing ionic strength and Mg2+ concentration, phospholipid binding is associated with the C-terminal part of the 130/133 kDa myosin-binding subunit and the 20 kDa regulatory subunit
-
-
-
additional information
?
-
-
130 kDa subunit MLCPa: elongated structure with 3 globular domains connected by flexible strands
-
-
-
additional information
?
-
-
interactions among the 38 kDa catalytic subunit PP1c, the 130 kDa and the 20 kDa non-catalytic subunits M130 and M20 or fragments of them, M130 has 2 binding sites for PP1c: one site in the N-terminal 38 residues and a weaker site in the ankyrin repeats region, activation of phosphatase and binding of PP1c and substrate are properties of the N-terminal one-third of M130
-
-
-
additional information
?
-
-
involved in force regulation in smooth muscle, the relative expression of splice-in/splice-out myosin-targeting subunit isoforms determines the magnitude of agonist-induced force enhancement/Ca2+ sensitization
-
-
-
additional information
?
-
-
130 kDa subunit MLCPa: elongated structure with 3 globular domains connected by flexible strands
-
-
-
additional information
?
-
role of the heart-specific small regulatory subunit hHS-M21 of MLCP
-
-
-
additional information
?
-
-
thrombin activates the Rho/Rho kinase pathway to inactivate myosin light chain phosphatase as part of a signaling network that controls myosin light chain phosphorylation and contraction in endothelial cells
-
-
-
additional information
?
-
-
plays a key role in platelet function
-
-
-
additional information
?
-
-
myosin phosphatase subunits protein phosphatase 1beta (PP1beta) and myosin phosphatase targeting subunit (Mypt1) interact with transcription factor Nkx2.5 and inhibit its transcriptional activity
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
KAMPPase: kinase- and myosin-associated protein phosphatase, functional multienzyme complex composed of a myofibrillar form of smooth muscle myosin light chain phosphatase and myosin light chain kinase with or without calmodulin, regulation of the phosphatase activity
-
-
-
additional information
?
-
-
two forms of SMP-I, the intact form and the catalytic subunit, may act in an opposite manner to regulate smooth muscle contraction in vivo
-
-
-
additional information
?
-
-
together with myosin light chain kinase key regulatory enzyme of smooth muscle
-
-
-
additional information
?
-
-
regulation of the MLCP activity
-
-
-
additional information
?
-
-
involved in the regulation of smooth muscle contraction, regulation of the MLCP activity
-
-
-
additional information
?
-
-
pulmonary hypertension down-regulates pulmonary vascular MLCP expression, the maintenance of a high pulmonary vascular resistance may be secondary to abnormalities in tissue content and/or activity of MLCP
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
studies with fragments of the 110 kDa subunit on their ability to regulate relaxation and 20 kDa myosin light-chain dephosphorylation of rabbit permeabilized portal vein induced by the catalytic subunit PP1C
-
-
-
additional information
?
-
-
insulin stimulates the binding of MRIP (myosin phosphatase Rho-interacting protein) to MYPT1 in a dose- and time-dependent manner, as determined by immunoprecipitation
-
-
-
additional information
?
-
-
studies with fragments of the 110 kDa subunit on their ability to regulate relaxation and 20 kDa myosin light-chain dephosphorylation of rabbit permeabilized portal vein induced by the catalytic subunit PP1C
-
-
-
additional information
?
-
-
regulation mechanism of MLCP activity
-
-
-
additional information
?
-
-
involved in smooth muscle relaxation
-
-
-
additional information
?
-
-
studies with fragments of the 110 kDa subunit on their ability to regulate relaxation and 20 kDa myosin light-chain dephosphorylation of rabbit permeabilized portal vein induced by the catalytic subunit PP1C
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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(S)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine
-
H-1152, 0.0003 mM produces a strong inhibition of basal MYPT1-pT853 by nearly 75%, KCl produces an approximate 1.75-2fold increase in MYPT1-pT853 in the presence and absence of H-1152
14-3-3beta protein
-
70% inhibition in the presence of 0.5 mM 14-3-3beta, dissociates MLCP from myosin II
-
acidic phospholipid
-
interaction of enzyme with acidic phospholipids inhibits activity toward phosphorylated myosin
-
ADP
-
SMP-I, catalytic subunit is more sensitive than holoenzyme
AMP
-
SMP-I, catalytic subunit is more sensitive than holoenzyme
arachidonic acid
-
inhibits SMPP-1M, dissociates the catalytic subunit from the native holoenzyme, inhibits the regulatory action of the 110 kDa/21 kDa subunit complex on the catalytic subunit PP1C activity, the C-terminal half of the 110 kDa subunit is required for inhibition
dephosphorylated myosin light chain
-
SMP-I, product inhibition
flavone
-
inhibits U46619-induced regulatory myosin light-chain phosphorylation
fragment 654-880 of human myosin phosphatase targeting subunit GST-fusion
-
-
-
fragment 697-880 of human myosin phosphatase targeting subunit GST-fusion
-
-
-
glycerol
-
inhibits SMMP activity, dissociates P-myosin primarily into an extended conformation
KCl
-
at high concentrations
MgATP2-
-
inhibits SMMP activity towards P-myosin, disassembles P-myosin mostly into a folded conformation
Mn2+
-
at 1 mM inhibitory effect
phosphate
-
SMP-I, holoenzyme and catalytic subunit, product inhibition
phosphatidic acid
-
most effective inhibitor among acidic phospholipids, followed by phosphatidylserine and phosphatidylinositol, phosphorylated myosin as substrate
phosphatidylinositol
-
phosphatidic acid is the most effective inhibitor among acidic phospholipids, followed by phosphatidylserine and phosphatidylinositol, phosphorylated myosin as substrate
phosphatidylserine
-
phosphatidic acid is the most effective inhibitor among acidic phospholipids, followed by phosphatidylserine and phosphatidylinositol, phosphorylated myosin as substrate
smoothelin-like 1 protein
-
originally called CHASM (calponin homology-associated smooth muscle), 55% inhibition at 0.0025 mM, 75% inhibition at up to 0.02 mM
-
tautomycetin
-
type 1 phosphatase inhibitor
tautomycin
-
PP-1M inhibitor
thrombin
-
activates Rho/Rho kinase to inactivate PP-1M
-
ATP

-
SMP-I, catalytic subunit is more sensitive than holoenzyme
ATP
-
enzyme SMP-IV is less sensitive than the other enzymes
Ca2+

-
partial inhibition of SMP-I, only with myosin light chain as substrate
Ca2+
-
inhibits at 0.01 mM
calyculin

-
type 1 and type 2A phosphatase inhibitor, inhibits MLCPPase
CPI-17

-
17-kDa protein kinase C-dependent MLCP inhibitor
-
CPI-17
-
specific inhibitor predominantly expressed in smooth muscles and neurons, phosphorylation of CPI-17 at Thr38 is necessary and sufficient to convert the protein into a potent inhibitor of myosin phosphatase
-
diphosphate

-
SMP-I, catalytic subunit is more sensitive than holoenzyme, most potent inhibitor among the phosphate analogs
diphosphate
-
enzyme SMP-IV is less sensitive than the other enzymes
Mg2+

-
above 5 mM
Mg2+
-
partial inhibition of SMP-I, only with myosin light chain as substrate
NaF

-
at high concentrations
NaF
-
enzyme SMP-IV is less sensitive than the other enzymes
okadaic acid

-
0.005 mM, more than 90% inhibition
okadaic acid
-
potent inhibitor of PP-1 and PP-2A
okadaic acid
-
at 1 nM almost complete inhibition of PP-2A
okadaic acid
-
more potent inhibitor of type 2A phosphatase than of type 1 phosphatase
okadaic acid
-
at 1 nM almost complete inhibition of PP-2A; PP-1: 0.001 mM, 88% inhibition
phospho-CPI-17

-
MLCP inhibitor protein, phosphorylation at Thr-38 of CPI-17 results in inhibition of MLCP activity
-
phospho-CPI-17
-
MLCP inhibitor protein, phosphorylation at Thr-38 of CPI-17 results in inhibition of MLCP activity; Rho kinase and protein kinase C phosphorylate CPI-17 at Thr-38, CPI-17 phosphorylation plays a role in MLCP regulation
-
Rho/Rho kinase

-
activated by thrombin to inactivate PP-1M
-
Rho/Rho kinase
-
Rho/Rho kinase-mediated inhibition of MLCPPase
-
additional information

-
elevation of cAMP and maximal cAMP-dependent protein kinase activation cause a 50% reduction in myosin II regulatory light chain phosphorylation and a 35% drop in isometric tension
-
additional information
-
increases in the ionic strength inhibit SMMP activity
-
additional information
-
inhibitory effect of several truncation mutants of the 130 kDa subunit M130 on the activity of the catalytic subunit PP1c, IC50 values
-
additional information
-
MLCP inhibition may occur through RhoA/Rhokinase and/or protein kinase C with phosphorylation of myosin phosphatase targeting subunit-1 and protein kinase C-potentiated phosphatase inhibitor (CPI-17), respectively
-
additional information
-
phosphorylation on Thr695 and Thr850 (inhibitory sites) result in inhibition
-
additional information
-
phosphorylation of myosin phosphatase targeting subunit on Thr696 and Thr853 (inhibitory sites) results in inhibition
-
additional information
-
inhibition of MLC phosphatase by either the catalytic subunit of MLC phosphatase, CS1beta, or myosin PPase targeting subunit 1, MYPT1, siRNA-based depletion results in significant attenuation of purine nucleotide (ATP and adenosine)-induced EC barrier enhancement
-
additional information
-
inhibitory effect of several truncation mutants of the 130 kDa subunit M130 on the activity of the catalytic subunit PP1c, IC50 values
-
additional information
-
relaxation of submaximally contracted mouse arteries with urocortin results in a decrease in phosphorylation of myosin light chain S19 by 60% and of enzyme regulatory subunit T696 and T850 by 28 and 52%, resp. Effect of urocortin is blocked by Rp-8-CPT-cAMPS and mimicked by Sp-5,6-DCl-cBIMPS
-
additional information
-
phosphorylation at Thr-695 of the MLCP regulatory subunit MYPT1 inhibits MLCP activity
-
additional information
-
phosphorylation of the myosin-binding subunit of MLCP at Thr-641 inhibits MLCP activity
-
additional information
-
forskolin, the phosphoinositide 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, LY 294002, and the Rho kinase inhibitor (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, Y27632, inhibit KCl-induced contraction in organ culture
-
additional information
-
pulmonary hypertension down-regulates pulmonary vascular MLCP expression
-
additional information
-
MLCP holoenzyme is inhibited by binding of 14-3-3beta protein to MYPT1, 14-3-3beta protein diminishes the binding between MYPT1 and myosin II, and abolishes MYPT1 localization at stress fibers
-
additional information
-
two major ROK phosphorylation sites, Thr697 and Thr855, on MYPT1 elicit MLCP inhibition. Phosphorylation of both sites inhibits MLCP activity. MYPT1-T855 phosphorylation may also interfere with the binding of MYPT1 to myosin
-
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monomer
-
1 * 43000, enzyme SMP-II
?

-
x * 130000 + x * 38000 + x * 20000, 130 kDa regulatory myosin-binding subunit, 38 kDa catalytic subunit, 20 kDa regulatory subunit, SDS-PAGE
?
-
x * 130000 + x * 38000 + x * 20000, 38 kDa catalytic subunit PP1c, 130 kDa and 20 kDa non-catalytic subunits M130 and M20, investigation of the interactions among PP1c, M20 and various mutants of M130 using the yeast two-hybrid system
?
-
x * 130000 + x * 38000 + x * 20000, 130 kDa regulatory myosin-binding subunit, 38 kDa catalytic subunit, 20 kDa regulatory subunit, SDS-PAGE
-
?
-
x * 37000 + x * 67000, 37 kDa catalytic subunit, 67 kDa targeting subunit binds to the catalytic subunit, to myosin light chain kinase and Ca2+-independently to calmodulin, ratio of subunits 1:2, MLCPase of the multienzyme complex with myosin light chain kinase is named KAMPPase, SDS-PAGE
?
-
x * 60000 + x * 55000 + x * 38000, 38 kDa catalytic subunit, ratio 1:1:1, enzyme SMP-I, SDS-PAGE
?
-
x * 58000 + x * 40000, enzyme SMP-IV; x * 60000 + x * 55000 + x * 38000, 38 kDa catalytic subunit, ratio 1:1:1, enzyme SMP-I, SDS-PAGE
heterotrimer

-
1 * 130000 + 1 * 38000 + 1 * 20000, 38 kDa catalytic subunit is the type 1delta isoform, 130 kDa regulatory subunit binds myosin and the catalytic subunit, amino acid sequences
heterotrimer
-
x * 130000 + x * 37000 + x * 20000, 37 kDa catalytic subunit, ratio 1:1:1, SDS-PAGE
heterotrimer
-
gizzard MP, 3 subunits: the two isoforms of the large subunit M130/M133 differ by a central insert at residues 512-552, the catalytic subunit PP1c delta isoform, two isoforms of the small subunit M20/M21 differing in the C-terminal sequence and in the presence or absence of leucin zipper motifs; interactions between the 3 subunits of MP
heterotrimer
-
x * 130000 + x * 37000 + x * 20000, 37 kDa catalytic subunit, ratio 1:1:1, SDS-PAGE
-
heterotrimer
-
interactions between the 3 subunits of MP
heterotrimer
-
1 * 110000 + 1 * 37000 + 1 * 21000, enzyme SMPP-1M, 37 kDa catalytic subunit PP1C, 110 kDa regulatory subunit M110
heterotrimer
-
1 * 110000 + 1 * 37000 + 1 * 21000, enzyme SMPP-1M, 37 kDa catalytic subunit PP1C, 110 kDa regulatory subunit M110
-
trimer

-
1 * 20000 + 1 * 38000 + 1 * 110000
trimer
-
myosin light chain phosphatase consists of a catalytic subunit, a large subunit, MYPT1 or MYPT2, and a small subunit
trimer
-
smooth muscle MLCP is a trimeric holoenzyme complex composed of 38 kDa PP1c-delat phosphatase, 110-130 kDa regulatory, myosin-targeting subunit, MYPT1, and a small, 20 kDa M20 subunit, presence of an acid residue cluster and LZ the presence of leucine zipper motifs in the LZ+ MYPT1 splice variant
additional information

-
MLCP is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1c PPC1, the myosin-binding subunit MBS, and M20
additional information
-
the myosin-targeting subunit MYPT has 2 isoforms produced by alternative splicing that differ by a central insert: 133 kDa splice-in and 130 kDa splice-out isoform, expression of the MYPT isoforms is both developmentally regulated and tissue-specific
additional information
-
structure and molecular properties of the 18.5 kDa isoform of the small subunit of MP with 21 kDa on SDS-PAGE and 18.4 kDa predicted from the amino acid sequence, 2 isoforms: 18.5 and 21 kDa, the small and the 107 kDa targeting subunit form a complex as 1:1 heterodimer
additional information
-
enzyme binds to retinoblastoma protein
additional information
-
structure and molecular properties of the 18.5 kDa isoform of the small subunit of MP with 21 kDa on SDS-PAGE and 18.4 kDa predicted from the amino acid sequence, 2 isoforms: 18.5 and 21 kDa, the small and the 107 kDa targeting subunit form a complex as 1:1 heterodimer
-
additional information
the heart-specific small regulatory subunit hHS-M21 of MLCP increases the Ca2+ sensitivity in muscle and binds to the large myosin-binding subunit, it plays a regulatory role in cardiac muscle contraction by its binding to the large subunit MBS, MBS encoded by the MYPT1 gene, not by MYPT2, is the main target subunit of hHS-M21
additional information
-
enzyme binds to retinoblastoma protein
additional information
-
The leucine-zipper motif at the N terminus of PKG forms a homodimeric coiled coil, the one at the C terminus of MYPT1 is monomeric and non-helical. The leucine-zipper motif of PKG binds to that of MYPT1 to form a heterodimer. When the leucine-zipper motif of MYPT1 is absent, the PKG leucine-zipper motif binds to the coiled coil region and upstream segments of MYPT1 via formation of a heterotetramer
additional information
-
myosin phosphatase is a complex that consists of a catalytic subunit protein phosphatase 1c, PP1cbeta, a large subunit myosin phosphatase targeting subunit, MYPT, and a small subunit. Stability of PP1cbeta and MYPT1 is interdependent, knocking down one of the subunits decreases the expression level of the other. MYPT1 binding is restricted to PP1cbeta, the central region of PP1cbeta confers the isoform-specific binding, while the variable, C-terminal domain of PP1cbeta is the region key for isoform-specific interaction with MYPT1. Sequence comparison of PP1 isoforms, overview
additional information
-
enzyme has 3 subunits, the catalytic subunit type 1 protein phosphatase delta, the regulatory subunit MYPT1 and a small subunit M20
additional information
-
enzyme has 3 subunits, the catalytic subunit type 1 protein phosphatase delta, the regulatory subunit MYPT1 in smooth muscle and MYPT 2 an isoform of MYPT1 in striated muscle
additional information
-
myosin phosphatase is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1 PP1, the myosin phosphatase targeting subunit MYPT1, and M21
additional information
-
myosin phosphatase is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1 PP1, the myosin phosphatase targeting subunit MYPT1, and M21
-
additional information
-
enzyme interacts with synaptophysin
additional information
-
myosin phosphatase is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1 PP1, the myosin phosphatase targeting subunit MYPT1, and M21
additional information
-
MLCP is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1c PPC1, the myosin phosphatase targeting subunit MYPT1, and M21
additional information
-
MLCP is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1c PPC1, the myosin phosphatase targeting subunit MYPT1, and M21
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Acute Lung Injury
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction.
Acute Lung Injury
The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo.
Adenoviridae Infections
Up-regulation of Rhoa/Rho kinase pathway by translationally controlled tumor protein in vascular smooth muscle cells.
Asthma
Airway Hyperresponsiveness in Asthma Model Occurs Independently of Secretion of ?1 Integrins in Airway Wall and Focal Adhesions Proteins Down Regulation.
Atherosclerosis
Differentially expressed soluble proteins in aortic cells from atherosclerosis-susceptible and resistant pigeons.
Atherosclerosis
Peach (Prunus persica) extract inhibits angiotensin II-induced signal transduction in vascular smooth muscle cells.
Atherosclerosis
ROS-mediated downregulation of MYPT1 in smooth muscle cells: a potential mechanism for the aberrant contractility in atherosclerosis.
Atrial Fibrillation
Expression of Rho Kinase and Its Mechanism in the Left Atrial Appendage in Patients with Atrial Fibrillation.
Carcinoma, Hepatocellular
Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells.
Colitis
Involvement of CPI-17 downregulation in the dysmotility of the colon from dextran sodium sulphate-induced experimental colitis in a mouse model.
Colonic Neoplasms
Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells.
Coronary Occlusion
Myosin phosphatase isoforms and related transcripts in the pig coronary circulation and effects of exercise and chronic occlusion.
Cystic Fibrosis
Rising behind NO: cGMP-dependent protein kinases.
Cysts
Protein phosphatase 1Ć limits ring canal constriction during Drosophila germline cyst formation.
Diabetes Mellitus, Type 2
Regulation of Smooth Muscle Myosin Light Chain Phosphatase by Multi-site Phosphorylation of the Myosin Targeting Subunit, MYPT1.
Endotoxemia
Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis.
Enterocolitis, Necrotizing
Expression of MYPT1, CPI-17 and MLC20 in ileum of neonatal mouse NEC model and its significance.
Frontotemporal Dementia
FTDP-17 missense mutations site-specifically inhibit as well as promote dephosphorylation of microtubule-associated protein tau by protein phosphatases of HEK-293 cell extract.
Gastroparesis
Impaired contractile responses and altered expression and phosphorylation of Ca(2+) sensitization proteins in gastric antrum smooth muscles from ob/ob mice.
Glioblastoma
Real time kinetic flow cytometry measurements of cellular parameter changes evoked by nanosecond pulsed electric field.
Heart Failure
Losartan decreases p42/44 MAPK signaling and preserves LZ+ MYPT1 expression.
Heart Failure
The potential role of MLC phosphatase and MAPK signalling in the pathogenesis of vascular dysfunction in heart failure.
Hyperalgesia
Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase?A as a Structure Surrogate.
Hyperglycemia
Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta.
Hypertension
Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.
Hypertension
Dynamic regulation of myosin light chain phosphorylation by Rho-kinase.
Hypertension
Enhanced Ca2+-dependent activation of phosphoinositide 3-kinase class II? isoform-Rho axis in blood vessels of spontaneously hypertensive rats.
Hypertension
Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats.
Hypertension
Peach (Prunus persica) extract inhibits angiotensin II-induced signal transduction in vascular smooth muscle cells.
Hypertension
Preserved expression of GLUT4 prevents enhanced agonist-induced vascular reactivity and MYPT1 phosphorylation in hypertensive mouse aorta.
Hypertension
Resveratrol prevents AngII-induced hypertension via AMPK activation and RhoA/ROCK suppression in mice.
Hypertension
Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy.
Hypertension, Portal
Dynamic changes in expression of myosin phosphatase in a model of portal hypertension.
Hypertension, Portal
Myosin phosphatase isoform switching in vascular smooth muscle development.
Hypertension, Pulmonary
Regulation of pulmonary arterial myosin phosphatase activity in neonatal circulatory transition and in hypoxic pulmonary hypertension: a role for CPI-17.
Hypertension, Pulmonary
The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas.
Hypertrophy, Right Ventricular
The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase.
Hypotension
Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle.
Infection
Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures.
Infection
Porcine Endogenous Retrovirus (PERV) Infection of HEK-293 Cell Line Alters Expression of Human Endogenous Retrovirus (HERV-W) Sequences.
Infection
The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro.
Influenza, Human
Accelerated mass production of influenza virus seed stocks in HEK-293 suspension cell cultures by reverse genetics.
Insulin Resistance
Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation.
Leiomyosarcoma
Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1.
Leukemia, Megakaryoblastic, Acute
Inhibition by Rho-kinase and protein kinase C of myosin phosphatase is involved in thrombin-induced shape change of megakaryocytic leukemia cell line UT-7/TPO.
Melanoma
Melanoma-expressed CD70 is involved in invasion and metastasis.
Muscle Spasticity
Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models.
Muscle Spasticity
Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.
Muscle Spasticity
Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery.
Muscular Atrophy
Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis.
Myocardial Ischemia
Altered Reactivity of Tertiary Mesenteric Arteries following Acute Myocardial Ischemia.
Myotonic Dystrophy
Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape.
Myotonic Dystrophy
Coiled-coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms.
Myotonic Dystrophy
Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.
Neoplasm Metastasis
The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice.
Neoplasms
Cardioprotective Effect of a Combination of Rho-Kinase Inhibitor and P38 MAPK Inhibitor on Cardiovascular Remodeling and Oxidative Stress in Dahl Rats.
Neoplasms
Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance.
Neoplasms
Deficiency in myosin light-chain phosphorylation causes cytokinesis failure and multipolarity in cancer cells.
Neoplasms
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.
Neoplasms
Differentially expressed soluble proteins in aortic cells from atherosclerosis-susceptible and resistant pigeons.
Neoplasms
Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor.
Neoplasms
Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.
Neoplasms
MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer.
Neoplasms
Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signaling.
Neoplasms
Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion.
Neoplasms
Rho-regulated myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation.
Neoplasms
The putative oncogene CPI-17 is up-regulated in schwannoma.
Neuroblastoma
Myosin phosphatase and RhoA-activated kinase modulate neurotransmitter release by regulating SNAP-25 of SNARE complex.
Neuroblastoma
O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins.
Neuroblastoma
The study of cellular cytotoxicity of argirelineĀ® - an anti-aging peptide.
Pneumonia
The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo.
Prostatic Neoplasms
Effects of a fluorescent Myosin light chain phosphatase inhibitor on prostate cancer cells.
Prostatic Neoplasms
Human type 3 5?-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride.
Pulmonary Edema
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction.
Rabies
Utility of human embryonic kidney cell line HEK-293 for rapid isolation of fixed and street rabies viruses: comparison with Neuro-2a and BHK-21 cell lines.
Retinoblastoma
Inhibition of protein phosphatase-1 and -2A decreases the chemosensitivity of leukemic cells to chemotherapeutic drugs.
Retinoblastoma
Localization of Myosin phosphatase target subunit and its mutants.
Retinoblastoma
Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells.
Retinoblastoma
Myosin phosphatase interacts with and dephosphorylates the retinoblastoma protein in THP-1 leukemic cells: Its inhibition is involved in the attenuation of daunorubicin-induced cell death by calyculin-A.
Sepsis
Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model.
Sepsis
Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis.
Shock, Septic
Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase.
Shock, Septic
The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries.
Spasm
Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.
Starvation
Metabolic Stress-Induced Activation of AMPK and Inhibition of Constitutive Phosphoproteins Controlling Smooth Muscle Contraction: Evidence for Smooth Muscle Fatigue?
Subarachnoid Hemorrhage
[Role of protein kinase C isozymes in cellular functions and pathological conditions]
Vascular Diseases
Dynamic regulation of myosin light chain phosphorylation by Rho-kinase.
Vasospasm, Intracranial
Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm.
Vasospasm, Intracranial
Thromboxane A2-induced bi-directional regulation of cerebral arterial tone.
Whooping Cough
Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation.
[myosin-light-chain] phosphatase deficiency
Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle.
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Sobieszek, A.; Borkowski, J.; Babiychuk, V.S.
Purification and characterization of a smooth muscle myosin light chain kinase-phosphatase complex
J. Biol. Chem.
272
7034-7041
1997
Meleagris gallopavo
brenda
Pato, M.D.; Adelstein, R.S.
Purification and characterization of a multisubunit phosphatase from turkey gizzard smooth muscle. The effect of calmodulin binding to myosin light chain kinase on dephosphorylation
J. Biol. Chem.
258
7047-7054
1983
Meleagris gallopavo
brenda
Houston, M.E.; Lingley, M.D.; Stuart, D.S.; Grange, R.W.
Myosin light chain phosphorylation in intact human muscle
FEBS Lett.
219
469-471
1987
Homo sapiens
brenda
Pato, M.D.; Kerc, E.
Purification of smooth muscle myosin phosphatase from turkey gizzard
Methods Enzymol.
159
446-453
1988
Meleagris gallopavo
brenda
Shimizu, H.; Ito, M.; Miyahara, M.; Ichikawa, K.; Okubo, S.; Konishi, T.; Naka, M.; Tanaka, T.; Hirano, K.; Hartshorne, D.J.; Nakano, T.
Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase
J. Biol. Chem.
269
30407-30411
1994
Gallus gallus
brenda
Chisholm, A.A.K.; Cohen, P.
The myosin-bound form of protein phosphatase 1 (PP-1M) is the enzyme that dephosphorylates native myosin in skeletal and cardiac muscles
Biochim. Biophys. Acta
971
163-169
1988
Bos taurus, Oryctolagus cuniculus
brenda
Alessi, D.; MacDougall, L.K.; Sola, M.M.; Ikebe, M.; Cohen, P.
The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1
Eur. J. Biochem.
210
1023-1035
1992
Gallus gallus, Gallus gallus PP-1
brenda
Sato, O.; Ogawa, Y.
Myosin assembly critical for the enzyme activity of smooth muscle myosin phosphatase: Effects of MgATP, ionic strength, and Mg2+
J. Biochem.
129
881-889
2001
Gallus gallus
brenda
Hirano, M.; Niiro, N.; Hirano, K.; Nishimura, J.; Hartshorne, D.J.; Kanaide, H.
Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells
Biochem. Biophys. Res. Commun.
254
490-496
1999
Sus scrofa (Q9TV77), Sus scrofa
brenda
Zhang, Y.; Mabuchi, K.; Tao, T.
Expression in insect cells and characterization of the 110 kDa anchoring subunit of myosin light chain phosphatase
Biochim. Biophys. Acta
1343
51-58
1997
Gallus gallus, Gallus gallus MLCP
brenda
Schmidt, U.S.; Troschka, M.; Pfitzer, G.
The variable coupling between force and myosin light chain phosphorylation in Triton-skinned chicken gizzard fibre bundles: Role of myosin light chain phosphatase
Pflugers Arch.
429
708-715
1995
Gallus gallus
brenda
Kitazawa, T.; Eto, M.; Woodsome, T.P.; Khalequzzaman, M.
Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle
J. Physiol.
546
879-889
2003
Oryctolagus cuniculus
brenda
Ito, M.; Feng, J.; Tsujino, S.; Inagaki, N.; Inagaki, M.; Tanaka, J.; Ichikawa, K.; Hartshorne, D.J.; Nakano, T.
Interaction of smooth muscle myosin phosphatase with phospholipids
Biochemistry
36
7607-7614
1997
Gallus gallus, Rattus norvegicus
brenda
Gailly, P.; Wu, X.; Haystead, T.A.J.; Somlyo, A.P.; Cohen, P.T.W.; Cohen, P.; Somlyo, A.V.
Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle
Eur. J. Biochem.
239
326-332
1996
Rattus norvegicus, Sus scrofa, Sus scrofa SMPP-1M
brenda
Belik, J.; Majumdar, R.; Fabris, V.E.; Kerc, E.; Pato, M.D.
Myosin light chain phosphatase and kinase abnormalities in fetal sheep pulmonary hypertension
Pediatr. Res.
43
57-61
1998
Ovis aries
brenda
Richards, C.T.; Ogut, O.; Brozovich, F.V.
Agonist-induced force enhancement. The role of isoforms and phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase
J. Biol. Chem.
277
4422-4427
2002
Gallus gallus
brenda
Langsetmo, K.; Stafford, W.F., 3rd; Mabuchi, K.; Tao, T.
Recombinant small subunit of smooth muscle myosin light chain phosphatase. Molecular properties and interactions with the targeting subunit
J. Biol. Chem.
276
34318-34322
2001
Gallus gallus, Gallus gallus PP-1M
brenda
Etter, E.F.; Eto, M.; Wardle, R.L.; Brautigan, D.L.; Murphy, R.A.
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Meleagris gallopavo, Meleagris gallopavo MLCP
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Homo sapiens
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Oryctolagus cuniculus, Rattus norvegicus
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Homo sapiens
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Gallus gallus, Meleagris gallopavo
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Homo sapiens (O60237)
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Homo sapiens
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Gallus gallus, Homo sapiens
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Payne, M.C.; Zhang, H.Y.; Shirasawa, Y.; Koga, Y.; Ikebe, M.; Benoit, J.N.; Fisher, S.A.
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Rattus norvegicus
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Belik, J.; Kerc, E.; Pato, M.D.
Rat pulmonary arterial smooth muscle myosin light chain kinase and phosphatase activities decrease with age
Am. J. Physiol.
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Rattus norvegicus
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Karim, S.M.; Rhee, A.Y.; Given, A.M.; Faulx, M.D.; Hoit, B.D.; Brozovich, F.V.
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Rattus norvegicus
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Lubomirov, L.T.; Reimann, K.; Metzler, D.; Hasse, V.; Stehle, R.; Ito, M.; Hartshorne, D.J.; Gagov, H.; Pfitzer, G.; Schubert, R.
Urocortin-induced decrease in Ca2+ sensitivity of contraction in mouse tail arteries is attributable to cAMP-dependent dephosphorylation of MYPT1 and activation of myosin light chain phosphatase
Circ. Res.
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Mus musculus
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Xia, D.; Stull, J.T.; Kamm, K.E.
Myosin phosphatase targeting subunit 1 affects cell migration by regulating myosin phosphorylation and actin assembly
Exp. Cell Res.
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Homo sapiens
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Goeckeler, Z.M.; Wysolmerski, R.B.
Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation
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Bos taurus
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Koga, Y.; Ikebe, M.
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Rattus norvegicus
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Localization of myosin phosphatase target subunit 1 in rat brain and in primary cultures of neuronal cells
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Rattus norvegicus
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Rattus norvegicus
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Wu, Y.; Muranyi, A.; Erdodi, F.; Hartshorne, D.J.
Localization of myosin phosphatase target subunit and its mutants
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Gallus gallus, Homo sapiens
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Wardle, R.L.; Gu, M.; Ishida, Y.; Paul, R.J.
Ca2+-desensitizing hypoxic vasorelaxation: pivotal role for the myosin binding subunit of myosin phosphatase (MYPT1) in porcine coronary artery
J. Physiol.
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2006
Sus scrofa
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Lu, Y.; Zhang, H.; Gokina, N.I.; Mandala, M.; Sato, O.; Ikebe, M.; Osol, G.; Fisher, S.A.
Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy
Am. J. Physiol. Cell Physiol.
294
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Rattus norvegicus
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Matsumura, F.; Hartshorne, D.J.
Myosin phosphatase target subunit: Many roles in cell function
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2007
Mammalia
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Okamoto, R.; Kato, T.; Mizoguchi, A.; Takahashi, N.; Nakakuki, T.; Mizutani, H.; Isaka, N.; Imanaka-Yoshida, K.; Kaibuchi, K.; Lu, Z.; Mabuchi, K.; Tao, T.; Hartshorne, D.J.; Nakano, T.; Ito, M.
Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart
Cell. Signal.
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Mammalia
brenda
Jeon, S.B.; Kim, G.; Kim, J.I.; Seok, Y.M.; Kim, S.H.; Suk, K.; Shin, H.M.; Lee, Y.H.; Kim, I.K.
Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit
Clin. Exp. Pharmacol. Physiol.
34
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Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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Mitonaka, T.; Muramatsu, Y.; Sugiyama, S.; Mizuno, T.; Nishida, Y.
Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells
Dev. Biol.
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2007
Drosophila melanogaster
brenda
Parra, M.; Mahmoudi, T.; Verdin, E.
Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes
Genes Dev.
21
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Mus musculus, Mus musculus BALB/c
brenda
Kirchner, J.; Gross, S.; Bennett, D.; Alphey, L.
The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila
Genetics
175
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2007
Drosophila melanogaster
brenda
Lee, E.; Hayes, D.B.; Langsetmo, K.; Sundberg, E.J.; Tao, T.C.
Interactions between the leucine-zipper motif of cGMP-dependent protein kinase and the C-terminal region of the targeting subunit of myosin light chain phosphatase
J. Mol. Biol.
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Homo sapiens
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Azam, M.A.; Yoshioka, K.; Ohkura, S.; Takuwa, N.; Sugimoto, N.; Sato, K.; Takuwa, Y.
Ca2+-independent, inhibitory effects of cyclic adenosine 5-monophosphate on Ca2+ regulation of phosphoinositide 3-kinase C2alpha, Rho, and myosin phosphatase in vascular smooth muscle
J. Pharmacol. Exp. Ther.
320
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2007
Oryctolagus cuniculus
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Watanabe, T.; Hosoya, H.; Yonemura, S.
Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells
Mol. Biol. Cell
18
605-616
2007
Canis lupus familiaris, Canis lupus familiaris Madin Darby
brenda
Koga, Y.; Ikebe, M.
A novel regulatory mechanism of myosin light chain phosphorylation via binding of 14-3-3 to myosin phosphatase
Mol. Biol. Cell
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2007
Rattus norvegicus
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Eto, M.; Kitazawa, T.; Matsuzawa, F.; Aikawa, S.; Kirkbride, J.A.; Isozumi, N.; Nishimura, Y.; Brautigan, D.L.; Ohki, S.
Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor
Structure
15
1591-1602
2007
Sus scrofa
brenda
Tomasek, J.J.; Vaughan, M.B.; Kropp, B.P.; Gabbiani, G.; Martin, M.D.; Haaksma, C.J.; Hinz, B.
Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity
Wound Repair Regen.
14
313-320
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Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Mizuno, Y.; Isotani, E.; Huang, J.; Ding, H.; Stull, J.T.; Kamm, K.E.
Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo
Am. J. Physiol. Cell Physiol.
295
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Homo sapiens
brenda
Sharma, A.K.; Zhou, G.P.; Kupferman, J.; Surks, H.K.; Christensen, E.N.; Chou, J.J.; Mendelsohn, M.E.; Rigby, A.C.
Probing the interaction between the coiled-coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C-terminus of the myosin binding subunit of the myosin light chain phosphatase
J. Biol. Chem.
283
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Homo sapiens
brenda
Wang, Y.; Zheng, X.R.; Riddick, N.; Bryden, M.; Baur, W.; Zhang, X.; Surks, H.K.
ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells
Circ. Res.
104
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Rattus norvegicus
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Ogut, O.; Brozovich, F.V.
The potential role of MLC phosphatase and MAPK signalling in the pathogenesis of vascular dysfunction in heart failure
J. Cell. Mol. Med.
12
2158-2164
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Homo sapiens
brenda
Ratz, P.H.; Miner, A.S.
Role of protein kinase Czeta and calcium entry in KCl-induced vascular smooth muscle calcium sensitization and feedback control of cellular calcium levels
J. Pharmacol. Exp. Ther.
328
399-408
2009
Oryctolagus cuniculus
brenda
Borman, M.A.; Freed, T.A.; Haystead, T.A.; Macdonald, J.A.
The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction
Mol. Cell. Biochem.
327
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2009
Oryctolagus cuniculus
brenda
Webb, J.D.; Muranyi, A.; Pugh, C.W.; Ratcliffe, P.J.; Coleman, M.L.
MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)
Biochem. J.
420
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2009
Homo sapiens, Meleagris gallopavo
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Kiss, A.; Lontay, B.; Becsi, B.; Markasz, L.; Olah, E.; Gergely, P.; Erdodi, F.
Myosin phosphatase interacts with and dephosphorylates the retinoblastoma protein in THP-1 leukemic cells: its inhibition is involved in the attenuation of daunorubicin-induced cell death by calyculin-A
Cell. Signal.
20
2059-2070
2008
Homo sapiens
brenda
Umeda, D.; Yamada, K.; Tachibana, H.
H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation
Eur. J. Pharmacol.
590
61-66
2008
Homo sapiens
brenda
Khromov, A.; Choudhury, N.; Stevenson, A.S.; Somlyo, A.V.; Eto, M.
Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction
J. Biol. Chem.
284
21569-21579
2009
Homo sapiens, Sus scrofa
brenda
Mori, S.; Iwaoka, R.; Eto, M.; Ohki, S.
Solution structure of the inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1
Proteins
77
732-735
2009
Homo sapiens (O14974)
brenda
Cole, W.C.; Welsh, D.G.
Role of myosin light chain kinase and myosin light chain phosphatase in the resistance arterial myogenic response to intravascular pressure
Arch. Biochem. Biophys.
510
160-173
2011
Rattus norvegicus
brenda
Matsumura, F.; Yamakita, Y.; Yamashiro, S.
Myosin light chain kinases and phosphatase in mitosis and cytokinesis
Arch. Biochem. Biophys.
510
76-82
2011
Homo sapiens
brenda
Okada, C.; Nakamura, A.; Tomioka, S.; Kohama, K.; Kaneko, T.S.
Purification and characterization of the plasmodial phosphatase that hydrolyses the phosphorylated light chain of Physarum myosin II from Physarum polycephalum
Cell Biol. Int.
34
827-835
2010
Physarum polycephalum
brenda
Sun, Y.; Yan, Y.; Denef, N.; Schuepbach, T.
Regulation of somatic myosin activity by protein phosphatase 1beta controls Drosophila oocyte polarization
Development
138
1991-2001
2011
Drosophila melanogaster
brenda
Shichi, D.; Arimura, T.; Ishikawa, T.; Kimura, A.
Heart-specific small subunit of myosin light chain phosphatase activates rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1
J. Biol. Chem.
285
33680-33690
2010
Homo sapiens
brenda
Scotto-Lavino, E.; Garcia-Diaz, M.; Du, G.; Frohman, M.A.
Basis for the isoform-specific interaction of myosin phosphatase subunits protein phosphatase 1c beta and myosin phosphatase targeting subunit 1
J. Biol. Chem.
285
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2010
Homo sapiens
brenda
Kim, K.M.; Csortos, C.; Czikora, I.; Fulton, D.; Umapathy, N.S.; Olah, G.; Verin, A.D.
Molecular characterization of myosin phosphatase in endothelium
J. Cell. Physiol.
227
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2012
Homo sapiens
brenda
Lee, J.H.; Palaia, T.; Ragolia, L.
Impaired insulin-stimulated myosin phosphatase Rho-interacting protein signaling in diabetic Goto-Kakizaki vascular smooth muscle cells
Am. J. Physiol. Cell Physiol.
302
C1371-C1381
2012
Rattus norvegicus
brenda
Khasnis, M.; Nakatomi, A.; Gumpper, K.; Eto, M.
Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1
Biochemistry
53
2701-2709
2014
Homo sapiens, Homo sapiens (O14974)
brenda
Ryan, T.; Shelton, M.; Lambert, J.P.; Malecova, B.; Boisvenue, S.; Ruel, M.; Figeys, D.; Puri, P.L.; Skerjanc, I.S.
Myosin phosphatase modulates the cardiac cell fate by regulating the subcellular localization of Nkx2.5 in a Wnt/Rho-associated protein kinase-dependent pathway
Circ. Res.
112
257-266
2013
Homo sapiens
brenda
Majumder, P.; Aranjuez, G.; Amick, J.; McDonald, J.A.
Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration
Curr. Biol.
22
363-372
2012
Drosophila melanogaster
brenda
Qiao, Y.N.; He, W.Q.; Chen, C.P.; Zhang, C.H.; Zhao, W.; Wang, P.; Zhang, L.; Wu, Y.Z.; Yang, X.; Peng, Y.J.; Gao, J.M.; Kamm, K.E.; Stull, J.T.; Zhu, M.S.
Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure
J. Biol. Chem.
289
22512-22523
2014
Mus musculus (Q9DBR7)
brenda
Iwasaki, T.; Katayama, T.; Kohama, K.; Endo, Y.; Sawasaki, T.
Myosin phosphatase is inactivated by caspase-3 cleavage and phosphorylation of myosin phosphatase targeting subunit 1 during apoptosis
Mol. Biol. Cell
24
748-756
2013
Homo sapiens (O14974), Mus musculus (Q9DBR7)
brenda
Jayashankar, V.; Nguyen, M.J.; Carr, B.W.; Zheng, D.C.; Rosales, J.B.; Rosales, J.B.; Weiser, D.C.
Protein phosphatase 1 beta paralogs encode the zebrafish myosin phosphatase catalytic subunit
PLoS ONE
8
e75766
2013
Danio rerio
brenda