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Literature summary for 3.1.3.53 extracted from

  • Hartshorne, D.J.
    Myosin phosphatase: Subunits and interactions (1998), Acta Physiol. Scand., 164, 483-493.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
several isoforms of the large targeting subunit MYPT are encoded by 2 genes: MYPT1 and MYPT2, located on chromosomes 12 and 1, structure of MYPT1, MYPT2 is cloned from brain Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information
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Homo sapiens
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-
additional information subcellular localization of the large subunit MYPT in embryo fibroblasts Gallus gallus
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stress fibers large subunit MYPT, embryo fibroblasts Gallus gallus
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-

Organism

Organism UniProt Comment Textmining
Gallus gallus
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MP, protein phosphatase type 1
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Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein large subunit MYPT1: phosphorylation site Thr-695, potential site for phosphorylation by protein kinase A is Thr-853 Homo sapiens
phosphoprotein Thr-654 and Thr-695 are the major phosphorylation sites of the large subunit MYPT isoforms M130 and M133 Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
brain expression of MYPT1 and MYPT2, the 2 isoforms of the large subunit Homo sapiens
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fibroblast embryonic, large myosin phosphatase target subunit MYPT Gallus gallus
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gizzard
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Gallus gallus
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heart expression of MYPT1 and MYPT2, the 2 isoforms of the large subunit Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myosin light-chain phosphate + H2O 20 kDa myosin light chain Gallus gallus myosin light-chain + phosphate
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?
myosin light-chain phosphate + H2O 20 kDa myosin light chain Homo sapiens myosin light-chain + phosphate
-
?
phosphorylated myosin + H2O
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Gallus gallus myosin + phosphate
-
?
phosphorylated myosin + H2O
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Homo sapiens myosin + phosphate
-
?

Subunits

Subunits Comment Organism
heterotrimer interactions between the 3 subunits of MP Gallus gallus
heterotrimer interactions between the 3 subunits of MP Homo sapiens
heterotrimer gizzard MP, 3 subunits: the two isoforms of the large subunit M130/M133 differ by a central insert at residues 512-552, the catalytic subunit PP1c delta isoform, two isoforms of the small subunit M20/M21 differing in the C-terminal sequence and in the presence or absence of leucin zipper motifs Gallus gallus