Cloned (Comment) | Organism |
---|---|
several isoforms of the large targeting subunit MYPT are encoded by 2 genes: MYPT1 and MYPT2, located on chromosomes 12 and 1, structure of MYPT1, MYPT2 is cloned from brain | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | - |
Homo sapiens | - |
- |
additional information | subcellular localization of the large subunit MYPT in embryo fibroblasts | Gallus gallus | - |
- |
stress fibers | large subunit MYPT, embryo fibroblasts | Gallus gallus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
MP, protein phosphatase type 1 | - |
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | large subunit MYPT1: phosphorylation site Thr-695, potential site for phosphorylation by protein kinase A is Thr-853 | Homo sapiens |
phosphoprotein | Thr-654 and Thr-695 are the major phosphorylation sites of the large subunit MYPT isoforms M130 and M133 | Gallus gallus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | expression of MYPT1 and MYPT2, the 2 isoforms of the large subunit | Homo sapiens | - |
fibroblast | embryonic, large myosin phosphatase target subunit MYPT | Gallus gallus | - |
gizzard | - |
Gallus gallus | - |
heart | expression of MYPT1 and MYPT2, the 2 isoforms of the large subunit | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
myosin light-chain phosphate + H2O | 20 kDa myosin light chain | Gallus gallus | myosin light-chain + phosphate | - |
? | |
myosin light-chain phosphate + H2O | 20 kDa myosin light chain | Homo sapiens | myosin light-chain + phosphate | - |
? | |
phosphorylated myosin + H2O | - |
Gallus gallus | myosin + phosphate | - |
? | |
phosphorylated myosin + H2O | - |
Homo sapiens | myosin + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterotrimer | interactions between the 3 subunits of MP | Gallus gallus |
heterotrimer | interactions between the 3 subunits of MP | Homo sapiens |
heterotrimer | gizzard MP, 3 subunits: the two isoforms of the large subunit M130/M133 differ by a central insert at residues 512-552, the catalytic subunit PP1c delta isoform, two isoforms of the small subunit M20/M21 differing in the C-terminal sequence and in the presence or absence of leucin zipper motifs | Gallus gallus |