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Literature summary for 3.1.3.53 extracted from

  • Etter, E.F.; Eto, M.; Wardle, R.L.; Brautigan, D.L.; Murphy, R.A.
    Activation of myosin light chain phosphatase in intact arterial smooth muscle during nitric oxide-induced relaxation (2001), J. Biol. Chem., 276, 34681-34685.
    View publication on PubMed
Search for more literature for 3.1.3.53

Activating Compound

Activating Compound Comment Organism Structure
sodium nitroprusside nitrovasodilator, increases MLCP activity in intact carotid media, mechanism Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
okadaic acid at 1 nM almost complete inhibition of PP-2A; PP-1: 0.001 mM, 88% inhibition Sus scrofa
phospho-CPI-17
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa involved in smooth muscle relaxation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
 MLCP, i.e. protein phosphatase type 1
-

Source Tissue

Source Tissue Comment Organism Textmining
carotid artery smooth muscle Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information regulation mechanism of MLCP activity Sus scrofa ?
-
 ?
additional information involved in smooth muscle relaxation Sus scrofa ?
-
 ?
myosin light-chain phosphate + H2O 20 kDa myosin light chain Sus scrofa myosin light-chain + phosphate
-
 ?
phosphorylated myosin + H2O from turkey gizzard Sus scrofa myosin + phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Sus scrofa