Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation at Thr-695 of the MLCP regulatory subunit MYPT1 inhibits MLCP activity | Oryctolagus cuniculus | |
phospho-CPI-17 | MLCP inhibitor protein, phosphorylation at Thr-38 of CPI-17 results in inhibition of MLCP activity | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
myosin light-chain phosphate + H2O | Oryctolagus cuniculus | plays a critical regulatory role in the Ca2+ sensitivity of myosin phosphorylation and smooth muscle contraction | myosin light-chain + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
male albino rabbits, MLCP, i.e. protein phosphatase type 1 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation at Thr-695 of the MLCP regulatory subunit MYPT1 inhibits MLCP activity, Thr-695 phosphorylation is independent of stimulation of G-proteins, Rho-kinase or protein kinase C, MYPT1 can also be phosphorylated at Thr-850, which is a non-inhibitory Rho-kinase site, Thr-850 phosphorylation is activated by G-proteins | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
portal vein | phasic smooth muscle | Oryctolagus cuniculus | - |
smooth muscle | phasic portal vein and vas deferens smooth muscles | Oryctolagus cuniculus | - |
vas deferens | phasic smooth muscle | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
myosin light-chain phosphate + H2O | - |
Oryctolagus cuniculus | myosin light-chain + phosphate | - |
? | |
myosin light-chain phosphate + H2O | plays a critical regulatory role in the Ca2+ sensitivity of myosin phosphorylation and smooth muscle contraction | Oryctolagus cuniculus | myosin light-chain + phosphate | - |
? |