Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calyculin | type 1 and type 2A phosphatase inhibitor, inhibits MLCPPase | Homo sapiens | |
okadaic acid | more potent inhibitor of type 2A phosphatase than of type 1 phosphatase | Homo sapiens | |
Rho/Rho kinase | Rho/Rho kinase-mediated inhibition of MLCPPase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
myosin light-chain phosphate + H2O | Homo sapiens | important role in regulating myofibroblast contraction, Rho/Rho kinase-mediated inhibition of MLCPPase is necessary for lysophosphatidic acid-promoted myofibroblast contraction, in contrast to smooth muscle cells, in which MLCPPase activity only regulates the sensitivity of the contractile response to Ca2+ | myosin light-chain + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
MLCPPase, member of type 1 phosphatases | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
myofibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
myosin light-chain phosphate + H2O | - |
Homo sapiens | myosin light-chain + phosphate | - |
? | |
myosin light-chain phosphate + H2O | important role in regulating myofibroblast contraction, Rho/Rho kinase-mediated inhibition of MLCPPase is necessary for lysophosphatidic acid-promoted myofibroblast contraction, in contrast to smooth muscle cells, in which MLCPPase activity only regulates the sensitivity of the contractile response to Ca2+ | Homo sapiens | myosin light-chain + phosphate | - |
? |