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Literature summary for 3.1.3.53 extracted from

  • Parizi, M.; Howard, E.W.; Tomasek, J.J.
    Regulation of LPA-promoted myofibroblast contraction: Role of Rho, myosin light chain kinase, and myosin light chain phosphatase (2000), Exp. Cell Res., 254, 210-220.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
calyculin type 1 and type 2A phosphatase inhibitor, inhibits MLCPPase Homo sapiens
okadaic acid more potent inhibitor of type 2A phosphatase than of type 1 phosphatase Homo sapiens
Rho/Rho kinase Rho/Rho kinase-mediated inhibition of MLCPPase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myosin light-chain phosphate + H2O Homo sapiens important role in regulating myofibroblast contraction, Rho/Rho kinase-mediated inhibition of MLCPPase is necessary for lysophosphatidic acid-promoted myofibroblast contraction, in contrast to smooth muscle cells, in which MLCPPase activity only regulates the sensitivity of the contractile response to Ca2+ myosin light-chain + phosphate
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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MLCPPase, member of type 1 phosphatases
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Source Tissue

Source Tissue Comment Organism Textmining
myofibroblast
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myosin light-chain phosphate + H2O
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Homo sapiens myosin light-chain + phosphate
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?
myosin light-chain phosphate + H2O important role in regulating myofibroblast contraction, Rho/Rho kinase-mediated inhibition of MLCPPase is necessary for lysophosphatidic acid-promoted myofibroblast contraction, in contrast to smooth muscle cells, in which MLCPPase activity only regulates the sensitivity of the contractile response to Ca2+ Homo sapiens myosin light-chain + phosphate
-
?