Literature summary for 3.1.3.53 extracted from

Bremer, J.; Granato, M.
Myosin phosphatase fine-tunes zebrafish motoneuron position during axonogenesis (2016), PLoS Genet., 12, e1006440 .

No PubMed abstract available

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Organism

Organism	UniProt	Comment	Textmining
Danio rerio	Z4YIS0	protein phosphatase 1 regulatory subunit 12A	-

General Information

General Information	Comment	Organism
physiological function	as motor axons exit from the spinal cord and extend through extracellular matrix produced by adjacent notochord cells,these cells shift several cell diameters caudally. Individual motoneuron cell bodies stay aligned with their extending axons. This alignment requires myosin phosphatase activity within motoneurons, and mutations in the myosin phosphatase subunit Mypt1 increase myosin phosphorylation causing a displacement between motoneuron cell bodies and their axons	Danio rerio

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Release 2023.1 (January 2023)