Cloned (Comment) | Organism |
---|---|
myosin-binding subunit of MLCP is cloned and expressed in SF9 cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation of the myosin-binding subunit of MLCP at Thr-641 inhibits MLCP activity | Oryctolagus cuniculus | |
phospho-CPI-17 | MLCP inhibitor protein, phosphorylation at Thr-38 of CPI-17 results in inhibition of MLCP activity; Rho kinase and protein kinase C phosphorylate CPI-17 at Thr-38, CPI-17 phosphorylation plays a role in MLCP regulation | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Oryctolagus cuniculus | involved in the regulation of smooth muscle contraction, regulation of the MLCP activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
New Zealand White rabbits, MLCP | - |
Rattus norvegicus | - |
myosin-binding subunit of MLCP | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of the myosin-binding subunit of MLCP at the inhibitory site Thr-641 inhibits MLCP activity, but may not play a significant role in a mechanism for MLCP regulation, Rho kinase phosphorylates Thr-799, but not Thr-641 | Oryctolagus cuniculus |
phosphoprotein | myosin-binding subunit of MLCP is phosphorylated at Thr-641 and Thr-799 by Rho kinase to 2 mol phosphate/mol of MBS | Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
recombinant myosin-binding subunit of MLCP, expressed in SF9 cells | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
smooth muscle | from femoral arteries | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | - |
Rattus norvegicus | ? | - |
? | |
additional information | regulation of the MLCP activity | Oryctolagus cuniculus | ? | - |
? | |
additional information | involved in the regulation of smooth muscle contraction, regulation of the MLCP activity | Oryctolagus cuniculus | ? | - |
? | |
myosin light-chain phosphate + H2O | - |
Oryctolagus cuniculus | myosin light-chain + phosphate | - |
? |