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Literature summary for 3.1.3.53 extracted from

  • Parra, M.; Mahmoudi, T.; Verdin, E.
    Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes (2007), Genes Dev., 21, 638-643.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.53

Cloned(Commentary)

Cloned (Comment) Organism
expression in DO11/10 T cells, downregulation of myosin phosphatase genes by using siRNA for PP1 isoforms and MYPT1 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 BALB/c
-
Mus musculus BALB/c
-
 BALB/c
-

Purification (Commentary)

Purification (Comment) Organism
by immunoprecipitation from primary thymocytes using anti-PP1a, anti-PP1b, anti-MYPT1 antibodies in combination with protein A-Sepharose slurry, myosin phosphatase subunits PP1b and MYPT1 coimmunoprecipitate with HDAC7 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
thymocyte T cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone deacetylase 7 phosphate + H2O HDAC7, dephosphorylation induces reimport into the nucleus Mus musculus histone deacetylase 7 + phosphate
-
 ?
histone deacetylase 7 phosphate + H2O HDAC7, dephosphorylation induces reimport into the nucleus Mus musculus BALB/c histone deacetylase 7 + phosphate
-
 ?
myosin light-chain phosphate + H2O
-
 Mus musculus myosin light-chain + phosphate
-
 ?
myosin light-chain phosphate + H2O
-
 Mus musculus BALB/c myosin light-chain + phosphate
-
 ?

Subunits

Subunits Comment Organism
More myosin phosphatase is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1 PP1, the myosin phosphatase targeting subunit MYPT1, and M21 Mus musculus

Synonyms

Synonyms Comment Organism
myosin phosphatase
-
 Mus musculus
MYPT1
-
 Mus musculus
PP1
-
 Mus musculus