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Literature summary for 3.1.3.53 extracted from

  • Mitonaka, T.; Muramatsu, Y.; Sugiyama, S.; Mizuno, T.; Nishida, Y.
    Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells (2007), Dev. Biol., 309, 78-86.
    View publication on PubMed
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Application

Application Comment Organism
medicine DMBS maintains epithelial integrity, loss of DMBS causes cell shape changes, loss of localization of the apical markers cadherin and increased accumulations of phospho-myosin regulatory light chain and F-actin, DMBS regulates the reorganization of cytoskeleton through down-regulation of myosin II, DMBS fits many of the criteria for a potential neoplastic type tumor suppressor gene Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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 wild type, DMBS null mutants and transheterozygotes with stronger and weaker alleles
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Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell imaginal disc epithelium of Drosophila Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myosin light-chain phosphate + H2O muscle Drosophila melanogaster myosin light-chain + phosphate
-
 ?
myosin regulatory light-chain phosphate + H2O nonmuscle Drosophila melanogaster myosin regulatory light-chain + phosphate
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 ?

Subunits

Subunits Comment Organism
More MLCP is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1c PPC1, the myosin-binding subunit MBS, and M20 Drosophila melanogaster

Synonyms

Synonyms Comment Organism
DMBS Drosophila homolog of MBS Drosophila melanogaster
MBS myosin-binding subunit Drosophila melanogaster
MLCP
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 Drosophila melanogaster
myosin light chain phosphatase
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 Drosophila melanogaster