Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.53 extracted from

  • Essler, M.; Amano, M.; Kruse, H.J.; Kaibuchi, K.; Weber, P.C.; Aepfelbacher, M.
    Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells (1998), J. Biol. Chem., 273, 21867-21874.
    View publication on PubMed
Search for more literature for 3.1.3.53

Inhibitors

Inhibitors Comment Organism Structure
Rho/Rho kinase activated by thrombin to inactivate PP-1M Homo sapiens
tautomycin PP-1M inhibitor Homo sapiens
thrombin activates Rho/Rho kinase to inactivate PP-1M Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens thrombin activates the Rho/Rho kinase pathway to inactivate myosin light chain phosphatase as part of a signaling network that controls myosin light chain phosphorylation and contraction in endothelial cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 myosin-associated PP-1M
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell from umbilical vein, myosin-bound PP-1M Homo sapiens
-
umbilical vein endothelium myosin-bound PP-1M Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information thrombin activates the Rho/Rho kinase pathway to inactivate myosin light chain phosphatase as part of a signaling network that controls myosin light chain phosphorylation and contraction in endothelial cells Homo sapiens ?
-
 ?
myosin light-chain phosphate + H2O from smooth muscle Homo sapiens myosin light-chain + phosphate
-
 ?
phosphorylated myosin + H2O
-
 Homo sapiens myosin + phosphate
-
 ?
phosphorylated phoshorylase B + H2O myosin-associated PP-1M Homo sapiens phosphorylase B + phosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens