Information on EC 4.2.1.11 - phosphopyruvate hydratase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY
4.2.1.11
-
RECOMMENDED NAME
GeneOntology No.
phosphopyruvate hydratase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
addition
-
-
-
-
elimination
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
1-butanol autotrophic biosynthesis
-
Bifidobacterium shunt
-
Biosynthesis of secondary metabolites
-
Entner-Doudoroff pathway II (non-phosphorylative)
-
Entner-Doudoroff pathway III (semi-phosphorylative)
-
ethylene biosynthesis V
-
formaldehyde assimilation I (serine pathway)
-
gluconeogenesis I
-
gluconeogenesis II (Methanobacterium thermoautotrophicum)
-
gluconeogenesis III
-
glucose and xylose degradation
-
glycerol degradation to butanol
-
Glycolysis / Gluconeogenesis
-
glycolysis I (from glucose-6P)
-
glycolysis II (from fructose-6P)
-
glycolysis III (from glucose)
-
glycolysis IV (plant cytosol)
-
glycolysis V (Pyrococcus)
-
glycolysis VI (metazoan)
-
heterolactic fermentation
-
Metabolic pathways
-
Methane metabolism
-
Microbial metabolism in diverse environments
-
photosynthetic 3-hydroxybutyrate biosynthesis
-
respiration (anaerobic)
-
Rubisco shunt
-
SYSTEMATIC NAME
IUBMB Comments
2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
Also acts on 3-phospho-D-erythronate.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
14-3-2 protein
-
-
2-phospho-D-glycerate hydro-lyase
-
-
-
-
2-phospho-D-glycerate hydrolase
Q4KVK5
-
2-phospho-D-glycerate hydrolase
D7NHW9
-
2-phospho-D-glycerate hydrolase
P00924
-
2-phospho-D-glycerate hydrolase
Q2THT8
-
2-phospho-D-glycerate hydrolase
Q4KYL2
-
2-phospho-D-glycerate hydrolase
Q4KYL6
-
2-phospho-D-glycerate hydrolase
Q9NDH8
-
2-phospho-D-glycerate hydrolyase
-
-
2-phospho-D-glycerate hydrolyase
-
-
2-phospho-D-glycerate hydrolyase
-
-
2-phospho-D-glycerate hydrolyase
-
-
2-phospho-D-glyceratehydrolyase
-
-
2-phosphoglycerate dehydratase
-
-
-
-
2-phosphoglycerate enolase
-
-
-
-
2-phosphoglyceric dehydratase
-
-
-
-
2-phosphopyruvate hydrolyase
-
-
alfa-enolase
-
-
alfa-enolase
Lactobacillus plantarum LM3
-
-
-
alpha,alpha-enolase
-
-
-
-
alpha-enolase
-
-
alpha-enolase
-
-
alpha-enolase
P06733
-
alpha-enolase
-
-
alpha-enolase
P04764
-
alpha-enolase
-
-
alpha-enolase
-
-
alpha-enolase 1
-
-
alpha-enolase 2
-
-
Alt a XI
-
-
-
-
beta,beta-enolase
-
-
-
-
beta,beta-enolase
-
-
beta-enolase
-
-
beta-enolase
-
-
Cla h VI
-
-
-
-
Csenolase
-
-
EhENO
C4LXE8
-
ENO
C9YSH7
-
Eno-alpha
-
-
ENO-S
-
-
Eno2
-
-
ENOA
-
-
EnoA I
Lactobacillus plantarum LM3
-
-
-
enolase
-
-
-
-
enolase
Q8MU59
-
enolase
C9YSH7
-
enolase
P37869
-
enolase
Bacillus subtilis 168
P37869
-
-
enolase
Q4KVK5
-
enolase
Bifidobacterium animalis subsp. lactis BI07
Q45RT9
-
-
enolase
Bifidobacterium bifidum S16
-
-
-
enolase
Bifidobacterium breve BBSF
-
-
-
enolase
Q8G5I9
-
enolase
Bifidobacterium longum S123
Q8G5I9
-
-
enolase
Q2YPV0
-
enolase
Brucella abortus A19
Q2YPV0
-
-
enolase
D7NHW9
-
enolase
Q96VP4
-
enolase
A1J8J9
-
enolase
-
-
enolase
Q967Y8
-
enolase
Eimeria tenella PaPt36
Q967Y8
-
-
enolase
C4LXE8
-
enolase
Entamoeba histolytica HM-1-IMSS
-
-
-
enolase
Entamoeba invadens IP-1
-
-
-
enolase
-
-
enolase
P0A6P9
-
enolase
Q5KVE7
-
enolase
Q9LEJ0
-
enolase
Leishmania mexicana AZV
Q3HL75
;
-
enolase
Leuconostoc mesenteroides B-512FMCM
Q1ET73
-
-
enolase
P17182, P21550
-
enolase
P25704
-
enolase
Paracoccidioides brasiliensis 18, Paracoccidioides brasiliensis ATCC MYA-826
A5JQI1
-
-
enolase
Q27727
-
enolase
Q8IJN7
-
enolase
Q7RA60
-
enolase
Plasmodium yoelii 17XL
Q7RA60
-
-
enolase
Q9UWJ5
-
enolase
Q2THT8
-
enolase
Q4KYL2
-
enolase
Q4KYL6
-
enolase
Q5DDV5
-
enolase
Q97QS2
-
enolase
Streptococcus pneumoniae R36A
Q97QS2
-
-
enolase
C6GGT7
-
enolase
C6GGT7
-
-
enolase
Streptomyces mutans, Streptomyces pneumoniae
-
-
enolase
-
-
enolase
Q9NDH8
-
enolase 1
-
-
enolase 1
Q4KYL6
-
enolase 1
-
-
enolase 2
-
-
enolase 2
-
-
enolase alpha
-
-
enolase gamma
-
-
enolase S
-
-
enolase-1
-
-
enolase-alpha
-
-
enolase-beta
-
-
Enolase-phosphatase E1
-
-
Enolase-phosphatase E1
Q5H0Y0
-
enolase2p
P00924
-
gamma,gamma-enolase
-
-
-
-
gamma-enolase
-
-
-
-
gamma-enolase
-
-
hENO1
P06733
-
HLE1
-
-
-
-
human alpha-enolase
P06733
-
human neuron-specific enolase
-
-
hydratase, phosphoenolpyruvate
-
-
-
-
Laminin binding protein
-
-
-
-
Major allergen Alt a 11
-
-
-
-
MASA
-
-
MSE
-
-
-
-
Neural enolase
-
-
-
-
neuron specific enolase
-
-
neuron-specific enolase
-
-
-
-
neuron-specific enolase
-
-
neuronal enolase
-
-
NNE
-
-
-
-
Non-neural enolase
-
-
-
-
NSE
-
-
-
-
OSE1
-
-
-
-
p45
C9YSH7
-
phosphoenolpyruvate enolase
-
-
phosphoenolpyruvate hydratase
-
-
-
-
Phosphopyruvate hydratase
-
-
-
-
Phosphopyruvate hydratase
-
-
plasminogen-binding alpha-enolase
-
-
R-NSE
-
-
-
-
rBaEn
-
recombinant protein expressed in Escherichia coli with a 6×-His tag
rSsEno
-
recombinant Streptococcus suis-enolase-protein with a His tag expressed in Escherichia coli
SjENO
Q5DDV5
-
Skeletal muscle enolase
-
-
-
-
streptococcal surface enolase
-
; SEN
Tau-crystallin
-
-
-
-
tv-rENO1
-
recombinant protein expressed as a glutathione S-transferase GST::tv-ENO1 fusion protein in Escherichia coli, cleaved using thrombin
XEP
Q5H0Y0
-
yeast enolase
P00924
-
CAS REGISTRY NUMBER
COMMENTARY
9014-08-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Archaeoglobus fulgidus 7324
-
-
-
Manually annotated by BRENDA team
strain ATCC 19213
-
-
Manually annotated by BRENDA team
strain 168
SwissProt
Manually annotated by BRENDA team
Bacillus subtilis 168
strain 168
SwissProt
Manually annotated by BRENDA team
strain BE1
Uniprot
Manually annotated by BRENDA team
Bacteroides fragilis BE1
strain BE1
Uniprot
Manually annotated by BRENDA team
Bifidobacterium animalis subsp. lactis BI07
strain BI07
UniProt
Manually annotated by BRENDA team
Bifidobacterium bifidum S16
strain S16
-
-
Manually annotated by BRENDA team
strain BBSF
-
-
Manually annotated by BRENDA team
Bifidobacterium breve BBSF
strain BBSF
-
-
Manually annotated by BRENDA team
strain S123
UniProt
Manually annotated by BRENDA team
Bifidobacterium longum S123
strain S123
UniProt
Manually annotated by BRENDA team
cow
-
-
Manually annotated by BRENDA team
strain strain BO5.10
A6RIS9
Uniprot
Manually annotated by BRENDA team
strain 2308, 100% sequence identity with strain A19
UniProt
Manually annotated by BRENDA team
Brucella abortus A19
strain 2308, 100% sequence identity with strain A19
UniProt
Manually annotated by BRENDA team
gene LOS2
UniProt
Manually annotated by BRENDA team
propagated in livers of male Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
Clostridium difficile
-
-
-
Manually annotated by BRENDA team
enolase 1 and 2
-
-
Manually annotated by BRENDA team
isolated from sheep in Qinghai province of China
-
-
Manually annotated by BRENDA team
strain PaPt36
SwissProt
Manually annotated by BRENDA team
Eimeria tenella PaPt36
strain PaPt36
SwissProt
Manually annotated by BRENDA team
Entamoeba histolytica HM-1-IMSS
-
-
-
Manually annotated by BRENDA team
strain IP-1
-
-
Manually annotated by BRENDA team
Entamoeba invadens IP-1
strain IP-1
-
-
Manually annotated by BRENDA team
gram-positive bacteria, ATCC9790
SwissProt
Manually annotated by BRENDA team
JA 200 pLC 11-8
-
-
Manually annotated by BRENDA team
the enzyme binds to human plasminogen
Uniprot
Manually annotated by BRENDA team
gamma-enolase
-
-
Manually annotated by BRENDA team
strain HTA426
SwissProt
Manually annotated by BRENDA team
clone RRIM 600
SwissProt
Manually annotated by BRENDA team
2 forms: homdimeric form and heterodimeric form
-
-
Manually annotated by BRENDA team
recombinant alpha-enolase
-
-
Manually annotated by BRENDA team
three genes, ENO1, ENO2 and ENO3 encoding for three isoforms of the enzyme, alpha-enolase, gamma-enolase, and beta-enolase, respectively
-
-
Manually annotated by BRENDA team
O3 strain 1069
-
-
Manually annotated by BRENDA team
Lactobacillus plantarum LM3
strain LM3
-
-
Manually annotated by BRENDA team
strain AZV
SwissProt
Manually annotated by BRENDA team
Leishmania mexicana AZV
strain AZV
SwissProt
Manually annotated by BRENDA team
strain B-512FMCM, constitutively secreting dextransucrase
SwissProt
Manually annotated by BRENDA team
Leuconostoc mesenteroides B-512FMCM
strain B-512FMCM, constitutively secreting dextransucrase
SwissProt
Manually annotated by BRENDA team
alpha,alpha-enolase
SwissProt
Manually annotated by BRENDA team
beta,beta-enolase
SwissProt
Manually annotated by BRENDA team
Paracoccidioides brasiliensis 18
strain 18
UniProt
Manually annotated by BRENDA team
Paracoccidioides brasiliensis ATCC MYA-826
-
UniProt
Manually annotated by BRENDA team
strain 3D7
SwissProt
Manually annotated by BRENDA team
strain NF54
-
-
Manually annotated by BRENDA team
strain 17XL
SwissProt
Manually annotated by BRENDA team
Plasmodium yoelii 17XL
strain 17XL
SwissProt
Manually annotated by BRENDA team
3 forms of the enzyme: enolase I, enolase II and enolase III
-
-
Manually annotated by BRENDA team
spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats
SwissProt
Manually annotated by BRENDA team
L. Cv. Baker 296
-
-
Manually annotated by BRENDA team
enolase 1 and mutant E168Q of enolase 1
-
-
Manually annotated by BRENDA team
exists in at least 3 distinct forms
-
-
Manually annotated by BRENDA team
mutant S39A of isoenzyme 1
-
-
Manually annotated by BRENDA team
strain BY4741 and strain DELTAGLO1
SwissProt
Manually annotated by BRENDA team
strain cat 1.S3-14A
-
-
Manually annotated by BRENDA team
isolate not clearly defined
TREMBL
Manually annotated by BRENDA team
isolates SFCornell, SF-Daft, SF-Florida
TREMBL
Manually annotated by BRENDA team
isolates SN-UCD1, SN-37R, SN-MU1, SN-MU2, SN-MUCAT2, SN-OT1
TREMBL
Manually annotated by BRENDA team
Anhui isolate, Chinese mainland strain, propagated in BALB/c mice
UniProt
Manually annotated by BRENDA team
Staphylococcus aureus Wood 46
Wood 46
Uniprot
Manually annotated by BRENDA team
DSM 320523
-
-
Manually annotated by BRENDA team
strain R36A
GenBank
Manually annotated by BRENDA team
Streptococcus pneumoniae R36A
strain R36A
GenBank
Manually annotated by BRENDA team
M6 strain D471; type M6 strain D471
-
-
Manually annotated by BRENDA team
Streptococcus ratti FA-1
FA-1
-
-
Manually annotated by BRENDA team
serotype 2, strain ZYS
-
-
Manually annotated by BRENDA team
strain 05ZYH33, serotype 2
UniProt
Manually annotated by BRENDA team
strain 05ZYH33, serotype 2
UniProt
Manually annotated by BRENDA team
Streptomyces mutans
-
-
-
Manually annotated by BRENDA team
Streptomyces pneumoniae
-
-
-
Manually annotated by BRENDA team
3 enolase isoforms
-
-
Manually annotated by BRENDA team
strain ISS413
-
-
Manually annotated by BRENDA team
Trichinella spiralis ISS413
strain ISS413
-
-
Manually annotated by BRENDA team
Xanthomonas oryzae pv. oryzae
UniProt
Manually annotated by BRENDA team
5 isoenzymes
-
-
Manually annotated by BRENDA team
3 isoelectric forms
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Bacillus subtilis (strain 168)
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Trypanosoma cruzi (strain CL Brener)
Renatured/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
solubilization of the recombinant enzyme from Escherichia coli inclusion bodies by 6 M urea
-