Literature summary for 4.2.1.11 extracted from

Jang, S.M.; Kim, J.W.; Kim, C.H.; Kim, D.; Rhee, S.; Choi, K.H.
p19(ras) Represses proliferation of non-small cell lung cancer possibly through interaction with neuron-specific enolase (NSE) (2010), Cancer Lett., 289, 91-98.

Search for more literature for 4.2.1.11

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
p19ras	when full-length p19ras and C-terminal region are bound to NSE, it inhibits the enzymatic activity of NSE, p19ras interacts with enolase alpha and represses its enzymatic activity in vitro	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
glutathione-Sepharose 4B bead chromatography, gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-
NCI-H1299 cell	-	Homo sapiens	-
neuron	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-phospho-D-glycerate	-	Homo sapiens	phosphoenolpyruvate + H2O	-	r

Synonyms

Synonyms	Comment	Organism
Eno-alpha	-	Homo sapiens
Eno2	-	Homo sapiens
enolase 2	-	Homo sapiens
enolase alpha	-	Homo sapiens
enolase gamma	-	Homo sapiens
neuron-specific enolase	-	Homo sapiens
NSE	-	Homo sapiens

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Release 2023.1 (January 2023)