Literature summary for 4.2.1.11 extracted from

Avilan, L.; Gualdron-Lopez, M.; Quinones, W.; Gonzalez-Gonzalez, L.; Hannaert, V.; Michels, P.A.; Concepcion, J.L.
Enolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites-perspectives for its use as a therapeutic target (2011), Enzyme Res., 2011, 932549.

Application

Application	Comment	Organism
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Giardia intestinalis
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Trypanosoma brucei
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Trichomonas vaginalis
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Streptococcus pyogenes
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Leishmania donovani
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Trypanosoma cruzi
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Candida albicans
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Aeromonas hydrophila
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Plasmodium falciparum
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Schistosoma japonicum
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Leishmania mexicana
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Eimeria tenella
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Leishmania major
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Leishmania infantum
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Fasciola hepatica
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Leishmania braziliensis
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Lactobacillus crispatus
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Streptomyces mutans
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Streptomyces pneumoniae
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Leishmania chagasi
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Schistosoma bovis
drug development	the glycolytic/gluconeogenic enzyme enolase is a candidate target for antiparasite drug design	Echinostoma caproni

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	associated to the external surface of the parasite	Giardia intestinalis	9986	-
cell surface	associated to the external surface of the parasite	Trichomonas vaginalis	9986	-
cell surface	associated to the external surface of the parasite	Streptococcus pyogenes	9986	-
cell surface	associated to the external surface of the parasite	Leishmania donovani	9986	-
cell surface	associated to the external surface of the parasite	Trypanosoma cruzi	9986	-
cell surface	associated to the external surface of the parasite	Schistosoma japonicum	9986	-
cell surface	associated to the external surface of the parasite	Leishmania mexicana	9986	-
cell surface	associated to the external surface of the parasite	Eimeria tenella	9986	-
cell surface	associated to the external surface of the parasite	Leishmania major	9986	-
cell surface	associated to the external surface of the parasite	Leishmania infantum	9986	-
cell surface	associated to the external surface of the parasite	Fasciola hepatica	9986	-
cell surface	associated to the external surface of the parasite	Leishmania braziliensis	9986	-
cell surface	associated to the external surface of the parasite	Lactobacillus crispatus	9986	-
cell surface	associated to the external surface of the parasite	Streptomyces mutans	9986	-
cell surface	associated to the external surface of the parasite	Streptomyces pneumoniae	9986	-
cell surface	associated to the external surface of the parasite	Leishmania chagasi	9986	-
cell surface	associated to the external surface of the parasite	Schistosoma bovis	9986	-
cell surface	associated to the external surface of the parasite	Echinostoma caproni	9986	-
cell surface	secreted enzyme associated to the external surface of the parasite	Candida albicans	9986	-
cell surface	secreted enzyme associated to the external surface of the parasite	Plasmodium falciparum	9986	-
cytosol	-	Leishmania mexicana	5829	-
extracellular	secreted enzyme	Giardia intestinalis	-	-
extracellular	secreted enzyme	Trichomonas vaginalis	-	-
extracellular	secreted enzyme	Streptococcus pyogenes	-	-
extracellular	secreted enzyme	Leishmania donovani	-	-
extracellular	secreted enzyme	Trypanosoma cruzi	-	-
extracellular	secreted enzyme	Schistosoma japonicum	-	-
extracellular	secreted enzyme	Leishmania mexicana	-	-
extracellular	secreted enzyme	Eimeria tenella	-	-
extracellular	secreted enzyme	Leishmania major	-	-
extracellular	secreted enzyme	Fasciola hepatica	-	-
extracellular	secreted enzyme	Leishmania braziliensis	-	-
extracellular	secreted enzyme	Lactobacillus crispatus	-	-
extracellular	secreted enzyme	Streptomyces mutans	-	-
extracellular	secreted enzyme	Streptomyces pneumoniae	-	-
extracellular	secreted enzyme	Schistosoma bovis	-	-
extracellular	secreted enzyme	Echinostoma caproni	-	-
extracellular	secreted enzyme associated to the external surface of the parasite	Candida albicans	-	-
extracellular	secreted enzyme associated to the external surface of the parasite	Plasmodium falciparum	-	-
additional information	enolase is found both in the secretome and in association with the surface	Giardia intestinalis	-	-
additional information	enolase is found both in the secretome and in association with the surface	Streptococcus pyogenes	-	-
additional information	enolase is found both in the secretome and in association with the surface	Schistosoma japonicum	-	-
additional information	enolase is found both in the secretome and in association with the surface	Eimeria tenella	-	-
additional information	enolase is found both in the secretome and in association with the surface	Fasciola hepatica	-	-
additional information	enolase is found both in the secretome and in association with the surface	Leishmania braziliensis	-	-
additional information	enolase is found both in the secretome and in association with the surface	Lactobacillus crispatus	-	-
additional information	enolase is found both in the secretome and in association with the surface	Streptomyces mutans	-	-
additional information	enolase is found both in the secretome and in association with the surface	Echinostoma caproni	-	-
additional information	enolase is found both in the secretome and in association with the surface of Leishmania spp.	Leishmania donovani	-	-
additional information	enolase is found both in the secretome and in association with the surface of Leishmania spp.	Leishmania major	-	-
additional information	enolase is found both in the secretome and in association with the surface of Leishmania spp.	Leishmania infantum	-	-
additional information	enolase is found both in the secretome and in association with the surface of Leishmania spp.	Leishmania chagasi	-	-
additional information	enolase is found both in the secretome and in association with the surface of Leishmania spp., no activity in microsomes. Enolase does not contain a detectable secretion signal or membrane anchor region that can explain its membrane localization	Leishmania mexicana	-	-
plasma membrane	-	Leishmania mexicana	5886	-
plasma membrane	enolase does not contain a detectable secretion signal or membrane anchor region that can explain its membrane localization	Leishmania infantum	5886	-
plasma membrane	enolase does not contain a detectable secretion signal or membrane anchor region that can explain its membrane localization	Leishmania chagasi	5886	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
2-phospho-D-glycerate	Giardia intestinalis	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Trypanosoma brucei	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Trichomonas vaginalis	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Streptococcus pyogenes	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Leishmania donovani	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Trypanosoma cruzi	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Candida albicans	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Aeromonas hydrophila	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Plasmodium falciparum	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Schistosoma japonicum	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Leishmania mexicana	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Eimeria tenella	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Leishmania major	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Leishmania infantum	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Fasciola hepatica	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Leishmania braziliensis	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Lactobacillus crispatus	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Streptomyces mutans	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Streptomyces pneumoniae	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Leishmania chagasi	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Schistosoma bovis	-	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	Echinostoma caproni	-	phosphoenolpyruvate + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Aeromonas hydrophila	-	-	-
Candida albicans	-	-	-
Echinostoma caproni	-	-	-
Eimeria tenella	-	-	-
Fasciola hepatica	-	-	-
Giardia intestinalis	-	-	-
Lactobacillus crispatus	-	-	-
Leishmania braziliensis	-	-	-
Leishmania chagasi	-	-	-
Leishmania donovani	-	-	-
Leishmania infantum	-	-	-
Leishmania major	-	-	-
Leishmania mexicana	-	-	-
Plasmodium falciparum	-	-	-
Schistosoma bovis	-	-	-
Schistosoma japonicum	-	-	-
Streptococcus pyogenes	-	-	-
Streptomyces mutans	-	-	-
Streptomyces pneumoniae	-	-	-
Trichomonas vaginalis	-	-	-
Trypanosoma brucei	-	-	-
Trypanosoma cruzi	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
amastigote	-	Trichomonas vaginalis	-
amastigote	-	Leishmania donovani	-
amastigote	-	Trypanosoma cruzi	-
amastigote	-	Schistosoma japonicum	-
amastigote	-	Leishmania mexicana	-
amastigote	-	Leishmania major	-
amastigote	-	Schistosoma bovis	-
promastigote	-	Trichomonas vaginalis	-
promastigote	-	Trypanosoma cruzi	-
promastigote	-	Schistosoma japonicum	-
promastigote	-	Leishmania mexicana	-
promastigote	-	Schistosoma bovis	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
2-phospho-D-glycerate	-	Giardia intestinalis	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Trypanosoma brucei	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Trichomonas vaginalis	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Streptococcus pyogenes	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Leishmania donovani	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Trypanosoma cruzi	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Candida albicans	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Aeromonas hydrophila	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Plasmodium falciparum	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Schistosoma japonicum	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Leishmania mexicana	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Eimeria tenella	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Leishmania major	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Leishmania infantum	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Fasciola hepatica	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Leishmania braziliensis	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Lactobacillus crispatus	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Streptomyces mutans	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Streptomyces pneumoniae	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Leishmania chagasi	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Schistosoma bovis	phosphoenolpyruvate + H2O	-	r
2-phospho-D-glycerate	-	Echinostoma caproni	phosphoenolpyruvate + H2O	-	r

Synonyms

Synonyms	Comment	Organism
enolase	-	Giardia intestinalis
enolase	-	Trypanosoma brucei
enolase	-	Trichomonas vaginalis
enolase	-	Streptococcus pyogenes
enolase	-	Leishmania donovani
enolase	-	Trypanosoma cruzi
enolase	-	Candida albicans
enolase	-	Aeromonas hydrophila
enolase	-	Plasmodium falciparum
enolase	-	Schistosoma japonicum
enolase	-	Leishmania mexicana
enolase	-	Eimeria tenella
enolase	-	Leishmania major
enolase	-	Leishmania infantum
enolase	-	Fasciola hepatica
enolase	-	Leishmania braziliensis
enolase	-	Lactobacillus crispatus
enolase	-	Streptomyces mutans
enolase	-	Streptomyces pneumoniae
enolase	-	Leishmania chagasi
enolase	-	Schistosoma bovis
enolase	-	Echinostoma caproni

General Information

General Information	Comment	Organism
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Giardia intestinalis
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Trypanosoma brucei
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Trichomonas vaginalis
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Streptococcus pyogenes
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Leishmania donovani
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Trypanosoma cruzi
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Candida albicans
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Aeromonas hydrophila
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Plasmodium falciparum
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Schistosoma japonicum
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Leishmania mexicana
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Eimeria tenella
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Leishmania major
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Leishmania infantum
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Fasciola hepatica
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Leishmania braziliensis
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Lactobacillus crispatus
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Streptomyces mutans
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Streptomyces pneumoniae
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Leishmania chagasi
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Schistosoma bovis
metabolism	enolase is the enzyme responsible for the reversible conversion of D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis, two metabolic pathways that are often vital for cellular function	Echinostoma caproni
physiological function	enolase can act as a plasminogen-binding protein	Candida albicans
physiological function	enolase can act as a plasminogen-binding protein	Plasmodium falciparum
physiological function	enolase can act as a plasminogen-binding protein	Schistosoma bovis
physiological function	enolase can act as a plasminogen-binding protein, an internal motif, FYDAEKKEY, is responsible for the plasminogen recognition	Aeromonas hydrophila
physiological function	enolase can act as a plasminogen-binding protein, an internal motif, FYDKERKVYD, is responsible for the plasminogen recognition	Streptomyces pneumoniae
physiological function	enolase is found both in the secretome and in association with the surface of Leishmania spp. where it probably functions as plasminogen receptor, playing a role in the parasite's invasiveness and virulence, a function possibly also present in the other trypanosomatids	Leishmania donovani
physiological function	enolase is found both in the secretome and in association with the surface of Leishmania spp. where it probably functions as plasminogen receptor, playing a role in the parasite's invasiveness and virulence, a function possibly also present in the other trypanosomatids	Leishmania major
physiological function	enolase is found both in the secretome and in association with the surface of Leishmania spp. where it probably functions as plasminogen receptor, playing a role in the parasite's invasiveness and virulence, a function possibly also present in the other trypanosomatids	Leishmania infantum
physiological function	enolase is found both in the secretome and in association with the surface of Leishmania spp. where it probably functions as plasminogen receptor, playing a role in the parasite's invasiveness and virulence, a function possibly also present in the other trypanosomatids	Leishmania chagasi
physiological function	enolase is found both in the secretome and in association with the surface of Leishmania spp. where it probably functions as plasminogen receptor, playing a role in the parasite's invasiveness and virulence, a function possibly also present in the other trypanosomatids. Enolase can act as a plasminogen-binding protein, an internal motif, AYDAERKMY, is responsible for the plasminogen recognition	Leishmania mexicana