3.4.23.5: cathepsin D
This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.
Word Map on EC 3.4.23.5
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3.4.23.5
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lysosomal
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pepstatin
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estrogen
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metastasis
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alzheimer
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proteinases
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aspartyl
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node
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vacuole
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lymph
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renin
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pepsin
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endosomes
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progesterone
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hydrolases
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endocytic
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phagosomes
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amyloid
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beta-glucuronidase
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plasminogen
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mannose
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6-phosphate
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axillary
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autophagosomes
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saposins
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lysosomal-associated
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leupeptin
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plasmepsins
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beta-hexosaminidase
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missorting
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mannose-6-phosphate
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chymosin
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lysotracker
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lipofuscinosis
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lc3-ii
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autophagy-lysosomal
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rab7
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ceroid
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estrogen-regulated
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immunoradiometric
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medicine
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lc3
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lamp-1
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node-negative
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trans-golgi
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upa
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endocytosed
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node-positive
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c-erbb-2
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autolysosomes
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cation-independent
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molecular biology
- 3.4.23.5
- lysosomal
- pepstatin
- estrogen
- metastasis
- alzheimer
- proteinases
-
aspartyl
- node
- vacuole
- lymph
- renin
- pepsin
- endosomes
- progesterone
- hydrolases
-
endocytic
-
phagosomes
-
amyloid
- beta-glucuronidase
- plasminogen
- mannose
- 6-phosphate
-
axillary
-
autophagosomes
-
saposins
-
lysosomal-associated
- leupeptin
-
plasmepsins
- beta-hexosaminidase
-
missorting
- mannose-6-phosphate
- chymosin
-
lysotracker
- lipofuscinosis
-
lc3-ii
-
autophagy-lysosomal
- rab7
-
ceroid
-
estrogen-regulated
-
immunoradiometric
- medicine
- lc3
- lamp-1
-
node-negative
-
trans-golgi
- upa
-
endocytosed
-
node-positive
-
c-erbb-2
-
autolysosomes
-
cation-independent
- molecular biology
Reaction
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =
Synonyms
BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A
ECTree
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pH Range
pH Range on EC 3.4.23.5 - cathepsin D
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2 - 4.5
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pH 2.0: about 35% of maximal activity, pH 4.5: about 45% of maximal activity, hemoglobin as substrate
2 - 5
2.3 - 5
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pH 2.3: about 35% of maximal activity, pH 5.0: about 45% of maximal activity, digestion of denatured hemoglobin
2.5 - 5
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pH 2.5: about 95% of maximal activity, pH 5.0: about 20% of maximal activity, digestion of denatured hemoglobin
3 - 5
3.5 - 4.5
3.5 - 5
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pH 3.5: maximal activity, pH 5.0: about 50% of maximal activity, fibrinogen as substrate
5 - 8
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pH 5: about 60% of maximal activity, pH 8.0: about 55% of maximal activity, alpha-benzoyl-DL-Arg-p-nitroanilide
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pH 2.0: about 55% of maximal activity, pH 5.0: about40% of maximal activity, with albumin as substrate
2 - 5
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the relative activities at pH 2.0, 4.0, and 5.0 are about 57, 65.7, and 23%, respectively, of that at pH 3.0. Cathepsin D activity decreases significantly above pH 5.0 and is only 2% at pH 6.0
2 - 5
about 20% activity at pH 2.0, 100% activity at pH 3.0, about 80% activity at pH 4.0, no activity at pH 5.0
2 - 5
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pH 2.0: about 95% of maximal activity, pH 5.0: about 35% of maximal activity
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at pH 3.0: about 25% of maximum activity, at pH 5.0: about 45% of maximum activity, beta-endorphin hydrolysis
3 - 5
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cathepsin D shows low activity at pH 3 and 45% remaining activity is observed up to pH 5.0
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pH 3.5: about 55% of maximal activity, pH 4.5: about 80% of maximal activity
3.5 - 4.5
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pH 3.5: about 55% of maximal activity, pH 4.5: about 60% of maximal activity