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3.4.23.5: cathepsin D

This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.

Word Map on EC 3.4.23.5

Reaction

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =

Synonyms

BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.5 cathepsin D

pH Range

pH Range on EC 3.4.23.5 - cathepsin D

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2 - 3.5
-
about 65% of maximal activity at pH 2.0 and at pH 3.5
2 - 4.5
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pH 2.0: about 35% of maximal activity, pH 4.5: about 45% of maximal activity, hemoglobin as substrate
2 - 5
2.3 - 5
-
pH 2.3: about 35% of maximal activity, pH 5.0: about 45% of maximal activity, digestion of denatured hemoglobin
2.5 - 5
-
pH 2.5: about 95% of maximal activity, pH 5.0: about 20% of maximal activity, digestion of denatured hemoglobin
3 - 4.3
-
about 55% of maximal activity at pH 3.0 and at pH 4.3
3 - 5
3 - 8
-
-
3.5 - 4.5
3.5 - 5
-
pH 3.5: maximal activity, pH 5.0: about 50% of maximal activity, fibrinogen as substrate
5 - 8
-
pH 5: about 60% of maximal activity, pH 8.0: about 55% of maximal activity, alpha-benzoyl-DL-Arg-p-nitroanilide
additional information
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