Reference on EC 3.4.23.5 - cathepsin D
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Blum, J.S.; Fiani, M.L.; Stahl, P.D.
Localization of cathepsin D in endosomes: characterization and biological importance
Struct. Funct. Asp. Proteinases (Dunn, Ben M. ; ed. ) Plenum Press, New York
281-287
1991
Oryctolagus cuniculus, Mus musculus
Pohl, J.; Zaoral, M.; Jindra, A.; Kostka, V.
Purification of pepsins and cathepsin D by affinity chromatography on Sepharose 4B with an immobilized synthetic inhibitor
Anal. Biochem.
139
265-271
1984
Bos taurus
von Clausbruch, U.C.; Tschesche, H.
Cathepsin D from human leukocytes. Purification by affinity chromatography and properties of the enzyme
Biol. Chem. Hoppe-Seyler
369
683-691
1988
Homo sapiens
Bonelli, G.; Kay, J.; Tessitore, L.; Jupp, R.A.; Isidoro, C.; Norey, C.G.; Autelli, R.; Richards, A.D.; Baccino, F.M.
Purification and properties of cathepsin D from rat Yoshida ascites hepatoma AH-130
Biol. Chem. Hoppe-Seyler
369
323-327
1988
Rattus norvegicus
Sakamoto, W.; Satoh, F.; Nagasawa, S.; Handa, H.
Identification of T-kinin-Leu (T-kinin-containing peptide) released from T-kininogen by cathepsin D of granulomatous tissues in rats
Biochem. Biophys. Res. Commun.
150
1199-1206
1988
Rattus norvegicus
Brooks, S.; Tyler, C.R.; Carnevali, O.; Coward, K.; Sumpter, J.P.
Molecular characterization of ovarian cathepsin D in the rainbow trout, Oncorhynchus mykiss
Gene
201
45-54
1997
Oncorhynchus mykiss
Goldman-Levkovitz, S.; Rimon, A.; Rimon, S.
Purification properties and specificity of cathepsin D from Cyprinus carpio
Comp. Biochem. Physiol. B
112
147-151
1995
Cyprinus carpio
Imoto, T.; Okazaki, K.; Koga, H.; Yamada, H.
Specificity of rat liver cathepsin D
J. Biochem.
101
575-580
1987
Rattus norvegicus
Simon, D.I.; Ezratty, A.M.; Loscalzo, J.
The fibrin(ogen)olytic properties of cathepsin D
Biochemistry
33
6555-6563
1994
Homo sapiens
Machaiah, S.S.J.P.; Nair, P.M.
Activation of protease activity in rat peritoneal macrophages in protein deficiency: characterization of cathepsin D
Indian J. Exp. Biol.
34
641-646
1996
Rattus norvegicus
Agarwal, N.; Rich, D.H.
An improved cathepsin-D substrate and assay procedure
Anal. Biochem.
130
158-165
1983
Sus scrofa
Barth, R.; Afting, E.G.
Cathepsin D from pig myometrium
Biochem. J.
219
899-904
1984
Sus scrofa
Jiang, S.T.; Wang, Y.T.; Chen, C.S.
Purification and characterization of a proteinase identified as cathepsin D from tilapia muscle (Tilapia nilotica X Tilapia aurea).
J. Agric. Food Chem.
39
1597-1601
1991
Tilapia sp.
Mycek, M.J.
Cathepsins
Methods Enzymol.
9
285-315
1970
Bos taurus, Gallus gallus, Oryctolagus cuniculus
-
Barrett, A.J.
Cathepsin D and other carboxyl proteinases
Proteinases in Mammalian Cells and Tissues (Barrett, A. J. , ed. )
2
209-248
1977
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa
-
Krieger, T.J.; Hook, V.Y.H.
Purification and characterization of a cathepsin D protease from bovine chromaffin granule
Biochemistry
31
4223-4231
1992
Bos taurus
Ishikawa, I.; Cimasoni, G.
Isolation of cathepsin D from human leucocytes
Biochim. Biophys. Acta
480
228-240
1977
Homo sapiens
Cunningham, M.; Tang, J.
Purification and properties of cathepsin D from porcine spleen
J. Biol. Chem.
251
4528-4536
1976
Sus scrofa
Zull, J.E.; Chuang, J.
Characterization of parathyroid hormone fragments produced by cathepsin D
J. Biol. Chem.
260
1608-1613
1985
Bos taurus
Reichelt, D.; Jacobsohn, E.; Haschen, R.J.
Purification and properties of cathepsin D from human erythrocytes
Biochim. Biophys. Acta
341
15-26
1974
Homo sapiens
Rupova, L.; Keilova, H.; Tomasek, V.
Chemical characterization of cathepsin D inhibitor from potatoes
Collect. Czech. Chem. Commun.
42
2279-2286
1977
Bos taurus
-
Shewale, J.G.; Tang, J.
Amino acid sequence of porcine spleen cathepsin D
Proc. Natl. Acad. Sci. USA
81
3703-3707
1984
Sus scrofa
Woessner, J.F.; Shamberger, R.J.
Purification and properties of cathepsin D from bovine uterus
J. Biol. Chem.
246
1951-1960
1971
Bos taurus
Scarborough, P.E.; Richo, G.R.; Kay, J.; Conner, G.E.; Dunn, B.M.
Comparison of kinetic properties of native and recombinant human cathepsin D
Struct. Funct. Asp. Proteinases (Dunn, Ben M. ; ed. ) Plenum Press, New York
306
343-347
1991
Homo sapiens
Chen, H.C.; Zall, R.R.
Partial purification and characterization of cathepsin D-like and B-like acid proteases from surf clam viscera
J. Food Sci.
51
71-78
1986
Homo sapiens, Spisula solidissima
-
Gulnik, S.; Baldwin, E.T.; Trasova, N.; Erickson, J.
Human liver cathepsin D. Purification, crystallization and preliminary X-ray diffraction analysis of a lysosomal enzyme
J. Mol. Biol.
227
265-270
1992
Homo sapiens
Figueiredo, A.F.S.; Takii, Y.; Tsuji, H.; Kato, K.; Inagami, T.
Rat kidney renin and cathepsin D: purification and comparison of properties
Biochemistry
22
5476-5481
1983
Rattus norvegicus
Srivastava, P.N.; Ninjoor, V.
Isolation of rabbit testicular cathespin D and its role in the activation of proacrosin
Biochem. Biophys. Res. Commun.
109
63-69
1982
Oryctolagus cuniculus
Watabe, S.; Taguchi, S.; Ikeda, T.; Takada, M.; Yago, N.
Characterization of cathepsin D in porcine adrenocortical lysosomes
J. Biochem.
92
45-55
1982
Sus scrofa
Bieber, F.; Brachvogel, V.; Arni, R.; Fusek, M.; Metcalf, P.
Crystallization and initial crystallographic results for pepstatin A inhibited bovine cathepsin D
J. Mol. Biol.
227
1265-1268
1992
Bos taurus
Turk, V.; Kregar, I.; Gubensek, F.; Lebez, D.
In vitro transition of beef spleen cathepsin E into cathepsin D
Enzymologia
36
182-186
1969
Bos taurus
Okitani, A.; Matsumoto, T.; Kitamura, Y.; Kato, H.
Purification of cathepsin D from rabbit skeletal muscle and its action towards myofibrils
Biochim. Biophys. Acta
662
202-209
1981
Oryctolagus cuniculus
Doke, S.N.; Ninjoor, V.; Nadkarni, G.B.
Characterization of cathepsin D from the skeletal muscle of fresh water fish, Tilapia mossambica
Agric. Biol. Chem.
44
1521-1528
1980
Tilapia sp.
-
Huang, J.S.; Huang, S.S.; Tang, J.
Cathepsin D of mouse leukemia L1210 cells. Unusual intracellular localization and biochemical properties
J. Biol. Chem.
254
11405-11417
1979
Sus scrofa
Bowers, W.E.; Beyer, C.F.; Yago, N.
Cathepsin D of mouse leukemia L12010 cells. Unusual intracellular localization and biochemical properties
Biochim. Biophys. Acta
497
272-279
1977
Mus musculus
Woessner, J.F.
Purification of cathepsin D from cartilage and uterus and its action on the protein-polysaccharide complex of cartilage
J. Biol. Chem.
248
1634-1642
1973
Bos taurus, Gallus gallus, Oryctolagus cuniculus
Fukushima, K.; Gnoh, G.H.; Shinano, S.
Purification and properties of a proteolytic enzyme cathepsin D, from chicken muscle
Agric. Biol. Chem.
35
1495-1502
1971
Gallus gallus
-
Suzuki, A.; Okitani, A.; Fujimaki, M.
Studies on proteolysis in stored muscle. Part III. Some physicochemical properties and proteolytic specificity of the rabbit muscular cathepsin D
Agric. Biol. Chem.
33
579-585
1969
Oryctolagus cuniculus
-
Suzuki, A.; Fujimaki, M.
Studies on proteolysis in stored muscle. Part II. Purification and properties of a proteolytic enzyme, cathepsin D, from rabbit muscle
Agric. Biol. Chem.
32
975-982
1968
Oryctolagus cuniculus
-
Takahashi, T.; Tang, J.
Cathepsin D from porcine and bovine spleen
Methods Enzymol.
80
564-581
1981
Bos taurus, Sus scrofa
-
Pohl, J.; Bures, L.; Slavik, K.
Isolation and characterization of cathepsin D from human gasttric mucosa
Collect. Czech. Chem. Commun.
46
3302-3313
1981
Homo sapiens
-
Yamamoto, K.; Katsuda, N.; Himeno, M.; Kato, K.
Cathepsin D of rat spleen. Affinity purification and properties of two types of cathepsin D
Eur. J. Biochem.
95
459-467
1979
Rattus norvegicus
Barrett, A.J.
Purification of isoenzymes from human and chicken liver
Biochem. J.
117
601-607
1970
Gallus gallus, Homo sapiens
Nakamura, K.; Yonezawa, S.; Yoshizaki, N.
Vitellogenesis-related ovary cathepsin D from Xenopus laevis: purification and properties in comparison with liver cathepsin D
Comp. Biochem. Physiol. B
113
835-840
1996
Xenopus laevis
Blanco-Labra, A.; Martinez-Gallardo, N.A.; Sandoval-Cardoso, L.; Delano-Frier, J.
Purification and characterization of a digestive cathepsin D proteinase isolated from Tribolium castaneum larvae (Herbst)
Insect Biochem. Mol. Biol.
26
95-100
1996
Tribolium castaneum
Majer, P.; Collins, J.R.; Gulnik, S.V.; Erickson, J.W.
Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors
Protein Sci.
6
1458-1466
1997
Homo sapiens
Baldwin, E.T.; Bhat, T.N.; Gulnik, S.; Hosur, M.V.; Sowder, R.C.; Cachau, R.E.; Collins, J.; Silva, A.M.; Erickson, J.W.
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design
Proc. Natl. Acad. Sci. USA
90
6796-6800
1993
Homo sapiens
Suzuki, H.; Takeda, M.; Nishimura, T.
Enzymatic characterization of cathepsin D in rabbit brains with experimental neurofibrillary changes
Biochem. Mol. Biol. Int.
32
1033-1039
1994
Oryctolagus cuniculus
Metcalf, P.; Fusek, M.
Two crystal structures for cathepsin D: the lysosomal targeting signal and active site
EMBO J.
12
1293-1302
1993
Bos taurus, Homo sapiens
Journet, A.; Chapel, A.; Jehan, S.; Adessi, C.; Freeze, H.; Klein, G.; Garin, J.
Characterization of Dictyostelium discoideum cathepsin D. Molecular cloning, gene disruption, endo-lysosomal localization and sugar modifications
J. Cell Sci.
112
3833-3843
1999
Dictyostelium discoideum
Bazel, S.; Alhadeff, J.A.
Characterization of purified cathepsin D from malignmant human breast tissue
Int. J. Oncol.
14
315-319
1999
Homo sapiens
Canduri, F.; Ward, R.J.; de Azevedo, W.F.; Gomes, R.A.S.; Arni, R.K.
Purification and partial characterization of cathepsin D from porcine (Sus scrofa) liver using affinity chromatography
Biochem. Mol. Biol. Int.
45
797-803
1998
Sus scrofa
Retzek, H.; Steyrer, E.; Sanders, E.J.; Nimpf, J.; Schneider, W.J.
Molecular cloning and functional characterization of chicken cathepsin D, a key enzyme for yolk formation
DNA Cell Biol.
11
661-672
1992
Gallus gallus
Conner, G.E.
Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography
Biochem. J.
263
601-604
1989
Sus scrofa
Beyer, B.M.; Dunn, B.M.
Prime region subsite specificity characterization of human cathepsin D: the dominant role of position 128
Protein Sci.
7
88-95
1998
Homo sapiens
Ollinger, K.
Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes
Arch. Biochem. Biophys.
373
346-351
2000
Rattus norvegicus
Partanen, S.; Storch, S.; Loeffler, H.G.; Hasilik, A.; Tyynelae, J.; Braulke, T.
A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cells
Biochem. J.
369
55-62
2003
Mus musculus
Pimenta, D.C.; Oliveira, A.; Juliano, M.A.; Juliano, L.
Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin
Biochim. Biophys. Acta
1544
113-122
2001
Homo sapiens
Cater, S.A.; Lees, W.E.; Hill, J.; Brzin, J.; Kay, J.; Phylip, L.H.
Aspartic proteinase inhibitors from tomato and potato are more potent against yeast proteinase A than cathepsin D
Biochim. Biophys. Acta
1596
76-82
2002
Homo sapiens
Johansson, A.C.; Steen, H.; Ollinger, K.; Roberg, K.
Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine
Cell Death Differ.
10
1253-1259
2003
Homo sapiens
Nielsen, L.B.; Nielsen, H.H.
Purification and characterization of cathepsin D from herring muscle (Clupea harengus)
Comp. Biochem. Physiol. B
128
351-363
2001
Clupea harengus
Komai, T.; Kawabata, C.; Amano, M.; Lee, B.R.; Ichishima, E.
Todarepsin, a new cathepsin D from hepatopancreas of Japanese common squid (Todarodes pacificus)
Comp. Biochem. Physiol. B
137
373-382
2004
Todarodes pacificus
Cho, J.H.; Park, I.Y.; Kim, H.S.; Lee, W.T.; Kim, M.S.; Kim, S.C.
Cathepsin D produces antimicrobial peptide parasin I from histone H2A in the skin mucosa of fish
FASEB J.
16
429-431
2002
Silurus asotus
Shibata, M.; Koike, M.; Waguri, S.; Zhang, G.; Koga, T.; Uchiyama, Y.
Cathepsin D is specifically inhibited by deoxyribonucleic acids
FEBS Lett.
517
281-284
2002
Bos taurus
Nogami, M.; Takatsu, A.; Endo, N.; Ishiyama, I.
An immunohistochemical study on cathepsin D in human hippocampus
Histochem. J.
32
505-508
2000
Homo sapiens
Matveyeva, M.; Hartmann, C.B.; Harrison, M.T.; Cabral, G.A.; McCoy, K.L.
DELTA(9)-tetrahydrocannabinol selectively increases aspartyl cathepsin D proteolytic activity and impairs lysozyme processing by macrophages
Int. J. Immunopharmacol.
22
373-381
2000
Mus musculus
Bidere, N.; Lorenzo, H.K.; Carmona, S.; Laforge, M.; Harper, F.; Dumont, C.; Senik, A.
Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis
J. Biol. Chem.
278
31401-31411
2003
Homo sapiens
Bi, X.; Haque, T.S.; Zhou, J.; Skillman, A.G.; Lin, B.; Lee, C.E.; Kuntz, I.D.; Ellman, J.A.; Lynch, G.
Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus
J. Neurochem.
74
1469-1477
2000
Rattus norvegicus
Pimenta, D.C.; Chen, V.C.; Chao, J.; Juliano, M.A.; Juliano, L.
alpha1-antichymotrypsin and kallistatin hydrolysis by human cathepsin D
J. Protein Chem.
19
411-418
2000
Homo sapiens
Handley, C.J.; Mok, M.T.; Ilic, M.Z.; Adcocks, C.; Buttle, D.J.; Robinson, H.C.
Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH
Matrix Biol.
20
543-553
2001
Bos taurus
Tsukuba, T.; Okamoto, K.; Yasuda, Y.; Morikawa, W.; Nakanishi, H.; Yamamoto, K.
New functional aspects of cathepsin D and cathepsin E
Mol. Cells
10
601-611
2000
Homo sapiens, Mus musculus
Athauda, S.B.P.; Takahashi, K.
Cleavage specificities of aspartic proteinases toward oxidized insulin B chain at different pH values
Protein Pept. Lett.
9
289-294
2002
Bos taurus
Yasuda, Y.; Kohmura, K.; Kadowaki, T.; Tsukuba, T.; Yamamoto, K.
A new selective substrate for cathepsin E based on the cleavage site sequence of alpha2-macroglobulin
Biol. Chem.
386
299-305
2005
Rattus norvegicus
Johansson, P.O.; Chen, Y.; Belfrage, A.K.; Blackman, M.J.; Kvarnstroem, I.; Jansson, K.; Vrang, L.; Hamelink, E.; Hallberg, A.; Rosenquist, A.; Samuelsson, B.
Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs
J. Med. Chem.
47
3353-3366
2004
Homo sapiens
Johansson, P.O.; Lindberg, J.; Blackman, M.J.; Kvarnstroem, I.; Vrang, L.; Hamelink, E.; Hallberg, A.; Rosenquist, A.; Samuelsson, B.
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II
J. Med. Chem.
48
4400-4409
2005
Homo sapiens
Karwowska, A.; Roszkowska-Jakimiec, W.; Dabrowska, E.; Gacko, M.; Chlabicz, M.
The effect of temperature, acidification, and alkalization changes as well as ethanol on salivary cathepsin D activity
Adv. Med. Sci.
51 Suppl 1
59-61
2006
Homo sapiens
Schechter, I.; Ziv, E.
Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s)
Biol. Chem.
389
313-320
2008
Homo sapiens, Sus scrofa
Gui, Z.Z.; Lee, K.S.; Kim, B.Y.; Choi, Y.S.; Wei, Y.D.; Choo, Y.M.; Kang, P.D.; Yoon, H.J.; Kim, I.; Je, Y.H.; Seo, S.J.; Lee, S.M.; Guo, X.; Sohn, H.D.; Jin, B.R.
Functional role of aspartic proteinase cathepsin D in insect metamorphosis
BMC Dev. Biol.
6
49
2006
Bombyx mori (Q7Z1E4), Bombyx mori
Trincheri, N.F.; Nicotra, G.; Follo, C.; Castino, R.; Isidoro, C.
Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D
Carcinogenesis
28
922-931
2007
Homo sapiens
Minarowska, A.; Minarowski, L.; Karwowska, A.; Sands, D.; Dabrowska, E.
The activity of cathepsin D in saliva of cystic fibrosis patients
Folia Histochem. Cytobiol.
45
165-168
2007
Homo sapiens
Follo, C.; Castino, R.; Nicotra, G.; Trincheri, N.F.; Isidoro, C.
Folding, activity and targeting of mutated human cathepsin D that cannot be processed into the double-chain form
Int. J. Biochem. Cell Biol.
39
638-649
2007
Homo sapiens
Kannappan, R.; Satoh, Y.; Iriyama, N.; Ando, M.; Sawada, M.T.; Takahashi, N.; Furuhata, K.; Uda, Y.
Identification and characterization of cathepsin D in a highly purified sialidase from starfish A. pectinifera
J. Biochem.
143
117-122
2008
Patiria pectinifera
Haidar, B.; Kiss, R.S.; Sarov-Blat, L.; Brunet, R.; Harder, C.; McPherson, R.; Marcel, Y.L.
Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux
J. Biol. Chem.
281
39971-39981
2006
Homo sapiens, Mus musculus
Baechle, D.; Flad, T.; Cansier, A.; Steffen, H.; Schittek, B.; Tolson, J.; Herrmann, T.; Dihazi, H.; Beck, A.; Mueller, G.A.; Mueller, M.; Stevanovic, S.; Garbe, C.; Mueller, C.A.; Kalbacher, H.
Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L
J. Biol. Chem.
281
5406-5415
2006
Homo sapiens
Conus, S.; Perozzo, R.; Reinheckel, T.; Peters, C.; Scapozza, L.; Yousefi, S.; Simon, H.U.
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation
J. Exp. Med.
205
685-698
2008
Homo sapiens, Mus musculus
Lou, X.; Xiao, T.; Zhao, K.; Wang, H.; Zheng, H.; Lin, D.; Lu, Y.; Gao, Y.; Cheng, S.; Liu, S.; Xu, N.
Cathepsin D is secreted from M-BE cells: its potential role as a biomarker of lung cancer
J. Proteome Res.
6
1083-1092
2007
Homo sapiens
Morales, M.E.; Rinaldi, G.; Gobert, G.N.; Kines, K.J.; Tort, J.F.; Brindley, P.J.
RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade
Mol. Biochem. Parasitol.
157
160-168
2008
Schistosoma mansoni
Demoz, M.; Castino, R.; Follo, C.; Hasilik, A.; Sloane, B.F.; Isidoro, C.
High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells
Protein Expr. Purif.
45
157-167
2006
Homo sapiens
Fritchie, K.; Siintola, E.; Armao, D.; Lehesjoki, A.E.; Marino, T.; Powell, C.; Tennison, M.; Booker, J.M.; Koch, S.; Partanen, S.; Suzuki, K.; Tyynelae, J.; Thorne, L.B.
Novel mutation and the first prenatal screening of cathepsin D deficiency (CLN10)
Acta Neuropathol.
117
201-208
2009
Homo sapiens
Markicevic, M.; Petrovic, A.; Kanjer, K.; Neskovic-Konstantinovic, Z.; Nikolic-Vukosavujevic, D.
Estrogen-regulated cut-off values of pS2 and cathepsin D expression in breast carcinomas
Adv. Exp. Med. Biol.
617
341-348
2008
Homo sapiens
Beaujouin, M.; Liaudet-Coopman, E.
Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity
Adv. Exp. Med. Biol.
617
453-461
2008
Homo sapiens
Fernandez-Aguilar, S.; Noel, J.C.
Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast
APMIS
116
33-40
2008
Homo sapiens
Zaidi, N.; Maurer, A.; Nieke, S.; Kalbacher, H.
Cathepsin D: a cellular roadmap
Biochem. Biophys. Res. Commun.
376
5-9
2008
Homo sapiens, Clupea harengus (Q9DEX3)
Zaragoza, R.; Torres, L.; Garcia, C.; Eroles, P.; Corrales, F.; Bosch, A.; Lluch, A.; Garcia-Trevijano, E.R.; Vina, J.R.
Nitration of cathepsin D enhances its proteolytic activity during mammary gland remodelling after lactation
Biochem. J.
419
279-288
2009
Mus musculus, Rattus norvegicus (P24268)
Sevlever, D.; Jiang, P.; Yen, S.H.
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species
Biochemistry
47
9678-9687
2008
Homo sapiens (P07339), Mus musculus (P10605)
Salvioli, R.; Ricci-Vitiani, L.; Tatti, M.; Scarpa, S.; De Maria, R.; Vaccaro, A.M.
The secretion and maturation of prosaposin and procathepsin D are blocked in embryonic neural progenitor cells
Biochim. Biophys. Acta
1783
1480-1489
2008
Homo sapiens
Zheng, X.; Chu, F.; Mirkin, B.L.; Sudha, T.; Mousa, S.A.; Rebbaa, A.
Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy
Biochim. Biophys. Acta
1783
2294-2300
2008
Homo sapiens
Bishop, M.T.; Kovacs, G.G.; Sanchez-Juan, P.; Knight, R.S.
Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease
BMC Med. genet.
9
31
2008
Homo sapiens (P07339), Homo sapiens
Hu, L.; Roth, J.M.; Brooks, P.; Luty, J.; Karpatkin, S.
Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis
Cancer Res.
68
4666-4673
2008
Homo sapiens (P07339), Homo sapiens
Sagulenko, V.; Muth, D.; Sagulenko, E.; Paffhausen, T.; Schwab, M.; Westermann, F.
Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death
Carcinogenesis
29
1869-1877
2008
Homo sapiens
Benes, P.; Vetvicka, V.; Fusek, M.
Cathepsin D - many functions of one aspartic protease
Crit. Rev. Oncol. Hematol.
68
12-28
2008
Homo sapiens
Castino, R.; Delpal, S.; Bouguyon, E.; Demoz, M.; Isidoro, C.; Ollivier-Bousquet, M.
Prolactin promotes the secretion of active cathepsin D at the basal side of rat mammary acini
Endocrinology
149
4095-4105
2008
Rattus norvegicus (P24268)
Wozniak, B.; Mila-Kierzenkowska, C.; Wozniak, A.; Drewa, G.; Soponska, M.; Drewa, T.; Krzyzynska-Malinowska, E.; Makarewicz, R.; Kowalski, T.; Szmytkowska, K.
The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer
Eur. J. Gynaecol. Oncol.
29
617-619
2008
Homo sapiens
Jia, A.; Zhang, X.H.
Molecular cloning, characterization and expression analysis of cathepsin D gene from turbot Scophthalmus maximus
Fish Shellfish Immunol.
26
606-613
2008
Scophthalmus maximus (B6C963), Scophthalmus maximus
Szajda, S.D.; Snarska, J.; Jankowska, A.; Roszkowska-Jakimiec, W.; Puchalski, Z.; Zwierz, K.
Cathepsin D and carcino-embryonic antigen in serum, urine and tissues of colon adenocarcinoma patients
Hepatogastroenterology
55
388-393
2008
Homo sapiens
Khalkhali-Ellis, Z.; Abbott, D.E.; Bailey, C.M.; Goossens, W.; Margaryan, N.V.; Gluck, S.L.; Reuveni, M.; Hendrix, M.J.
IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells
J. Cell. Biochem.
105
208-218
2008
Homo sapiens
Castino, R.; Peracchio, C.; Salini, A.; Nicotra, G.; Trincheri, N.F.; Demoz, M.; Valente, G.; Isidoro, C.
Chemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D - bax activation loop
J. Cell. Mol. Med.
13
1096-1109
2009
Homo sapiens
Breton, J.; Gage, M.C.; Hay, A.W.; Keen, J.N.; Wild, C.P.; Donnellan, C.; Findlay, J.B.; Hardie, L.J.
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barretts esophagus and esophageal adenocarcinoma
J. Proteome Res.
7
1953-1962
2008
Homo sapiens (P07339), Homo sapiens
Cheng, A.L.; Huang, W.G.; Chen, Z.C.; Zhang, P.F.; Li, M.Y.; Li, F.; Li, J.L.; Li, C.; Yi, H.; Peng, F.; Duan, C.J.; Xiao, Z.Q.
Identificating cathepsin D as a biomarker for differentiation and prognosis of nasopharyngeal carcinoma by laser capture microdissection and proteomic analysis
J. Proteome Res.
7
2415-2426
2008
Homo sapiens (P07339), Homo sapiens
Moon, C.; Lee, T.K.; Kim, H.; Ahn, M.; Lee, Y.; Kim, M.D.; Sim, K.B.; Shin, T.
Immunohistochemical study of cathepsin D in the spinal cords of rats with clip compression injury
J. Vet. Med. Sci.
70
937-941
2008
Rattus norvegicus
Perez-Victoria, F.J.; Mardones, G.A.; Bonifacino, J.S.
Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes
Mol. Biol. Cell
19
2350-2362
2008
Homo sapiens
Qiao, L.; Hamamichi, S.; Caldwell, K.A.; Caldwell, G.A.; Yacoubian, T.A.; Wilson, S.; Xie, Z.L.; Speake, L.D.; Parks, R.; Crabtree, D.; Liang, Q.; Crimmins, S.; Schneider, L.; Uchiyama, Y.; Iwatsubo, T.; Zhou, Y.; Peng, L.; Lu, Y.; Standaert, D.G.; Walls, K.C.; Shacka, J.J.; Roth, K.A.; Zhang, J.
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
Mol. Brain
1
17
2008
Caenorhabditis elegans, Mus musculus (P18242), Mus musculus
Cullen, V.; Lindfors, M.; Ng, J.; Paetau, A.; Swinton, E.; Kolodziej, P.; Boston, H.; Saftig, P.; Woulfe, J.; Feany, M.B.; Myllykangas, L.; Schlossmacher, M.G.; Tyynelae, J.
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
Mol. Brain
2
5-5
2009
Mus musculus, Rodentia sp.
Capurso, C.; Solfrizzi, V.; DIntrono, A.; Colacicco, A.M.; Capurso, S.A.; Bifaro, L.; Menga, R.; Santamato, A.; Seripa, D.; Pilotto, A.; Capurso, A.; Panza, F.
Short arm of chromosome 11 and sporadic Alzheimers disease: catalase and cathepsin D gene polymorphisms
Neurosci. Lett.
432
237-242
2008
Homo sapiens (P07339), Homo sapiens
Feron, D.; Begu-Le Corroller, A.; Piot, J.M.; Frelicot, C.; Vialettes, B.; Fruitier-Arnaudin, I.
Significant lower VVH7-like immunoreactivity serum level in diabetic patients: evidence for independence from metabolic control and three key enzymes in hemorphin metabolism, cathepsin D, ACE and DPP-IV
Peptides
30
256-261
2009
Homo sapiens
Masson, O.; Bach, A.S.; Derocq, D.; Prebois, C.; Laurent-Matha, V.; Pattingre, S.; Liaudet-Coopman, E.
Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?
Biochimie
92
1635-1643
2010
Homo sapiens
Miura, Y.; Sakurai, Y.; Hayakawa, M.; Shimada, Y.; Zempel, H.; Sato, Y.; Hisanaga, S.; Endo, T.
Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes
Biol. Pharm. Bull.
33
22-28
2010
Rattus norvegicus
Robert, F.; Bierau, H.; Rossi, M.; Agugiaro, D.; Soranzo, T.; Broly, H.; Mitchell-Logean, C.
Degradation of an Fc-fusion recombinant protein by host cell proteases: Identification of a CHO cathepsin D protease
Biotechnol. Bioeng.
104
1132-1141
2009
Cricetulus griseus
Byun, H.O.; Han, N.K.; Lee, H.J.; Kim, K.B.; Ko, Y.G.; Yoon, G.; Lee, Y.S.; Hong, S.I.; Lee, J.S.
Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence
Cancer Res.
69
4638-4647
2009
Homo sapiens
Vashishta, A.; Ohri, S.; Vetvicka, V.
Pleiotropic effects of cathepsin D
Endocr. Metab. Immune Disord. Drug Targets
9
385-391
2009
Homo sapiens
Cruz-Soto, M.E.; Cosio, G.; Jeziorski, M.C.; Vargas-Barroso, V.; Aguilar, M.B.; Carabez, A.; Berger, P.; Saftig, P.; Arnold, E.; Thebault, S.; Martinez de la Escalera, G.; Clapp, C.
Cathepsin D is the primary protease for the generation of adenohypophyseal vasoinhibins: cleavage occurs within the prolactin secretory granules
Endocrinology
150
5446-5454
2009
Rattus norvegicus
van der Hilst, J.C.; Kluve-Beckerman, B.; van der Meer, J.W.; Simon, A.
Cathepsin D activity protects against development of type AA amyloid fibrils
Eur. J. Clin. Invest.
39
412-416
2009
Homo sapiens
Minarowska, A.; Karwowska, A.; Gacko, M.
Quantitative determination and localization of cathepsin D and its inhibitors
Folia Histochem. Cytobiol.
47
153-177
2009
Rattus norvegicus
Buckow, R.; Truong, B.; Versteeg, C.
Bovine cathepsin D activity under high pressure
Food Chem.
120
474-481
2010
Bos taurus
Padilha, M.H.; Pimentel, A.C.; Ribeiro, A.F.; Terra, W.R.
Sequence and function of lysosomal and digestive cathepsin D-like proteinases of Musca domestica midgut
Insect Biochem. Mol. Biol.
39
782-791
2009
Musca domestica (A1YZ22), Musca domestica (A2ICG5), Musca domestica (A2ICG6), Musca domestica
Christensen, B.; Schack, L.; Klaening, E.; Sorensen, E.S.
Osteopontin is cleaved at multiple sites close to its integrin-binding motifs in milk and is a novel substrate for plasmin and cathepsin D
J. Biol. Chem.
285
7929-7937
2010
Homo sapiens
Ahn, J.E.; Zhu-Salzman, K.
CmCatD, a cathepsin D-like protease has a potential role in insect defense against a phytocystatin
J. Insect Physiol.
55
678-685
2009
Callosobruchus maculatus (C7AAS7)
Mutka, A.L.; Haapanen, A.; Kaekelae, R.; Lindfors, M.; Wright, A.K.; Inkinen, T.; Hermansson, M.; Rokka, A.; Corthals, G.; Jauhiainen, M.; Gillingwater, T.H.; Ikonen, E.; Tyynelae, J.
Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain
J. Neurochem.
112
193-203
2010
Mus musculus
Rojo, L.; Muhlia-Almazan, A.; Saborowski, R.; Garcia-Carreno, F.
Aspartic cathepsin D endopeptidase contributes to extracellular digestion in clawed lobsters Homarus americanus and Homarus gammarus
Mar. Biotechnol.
12
696-707
2010
Homarus americanus, Homarus gammarus
Li, C.; Zhang, H.; Li, L.; Song, L.
Identification of a cathepsin D potentially involved in H2A cleavage from scallop Chlamys farreri
Mol. Biol. Rep.
37
1451-1460
2010
Azumapecten farreri
Kuronen, M.; Talvitie, M.; Lehesjoki, A.E.; Myllykangas, L.
Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis
Neurobiol. Dis.
36
488-493
2009
Drosophila melanogaster
Fan, X.; Luo, G.; Yang, D.; Ming, M.; Liu, H.; Pu, P.; Le, W.
Critical role of lysosome and its associated protein cathepsin D in manganese-induced toxicity in cultured midbrain astrocyte
Neurochem. Int.
56
291-300
2010
Mus musculus
Sheikh, A.M.; Li, X.; Wen, G.; Tauqeer, Z.; Brown, W.T.; Malik, M.
Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects
Neuroscience
165
363-370
2010
Homo sapiens
Feron, D.; Piot, J.M.; Fruitier-Arnaudin, I.
Proteolytic degradation by cathepsin D of glycated hemoglobin from diabetes patients gives rise to hemorphin-7 peptides
Peptides
31
956-961
2010
Homo sapiens
Chida, K.; Taguchi, M.
Localization of alkaline phosphatase and cathepsin D during cell restoration after colchicine treatment in primary cultures of fetal rat hepatocytes
Acta Histochem. Cytochem.
44
155-158
2011
Rattus norvegicus
Amarante-Paffaro, A.M.; Hoshida, M.S.; Yokota, S.; Goncalves, C.R.; Joazeiro, P.P.; Bevilacqua, E.; Yamada, A.T.
Localization of cathepsins D and B at the maternal-fetal interface and the invasiveness of the trophoblast during the postimplantation period in the mouse
Cells Tissues Organs
193
417-425
2011
Mus musculus
Rojo, L.; Sotelo-Mundo, R.; Garcia-Carreno, F.; Graf, L.
Isolation, biochemical characterization, and molecular modeling of American lobster digestive cathepsin D1
Comp. Biochem. Physiol. B
157
394-400
2010
Homarus americanus
Merino, V.; Siva Kumar, N.
Isolation, affinity purification and biochemical characterization of a lysosomal cathepsin D from the deuterostome Asterias rubens
Comp. Biochem. Physiol. B
161
240-246
2012
Asterias rubens
Grimm, S.; Ernst, L.; Groetzinger, N.; Hoehn, A.; Breusing, N.; Reinheckel, T.; Grune, T.
Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins
Free Radic. Res.
44
1013-1026
2010
Mus musculus
Balti, R.; Hmidet, N.; Jellouli, K.; Nedjar-Arroume, N.; Guillochon, D.; Nasri, M.
Cathepsin D from the hepatopancreas of the cuttlefish (Sepia officinalis): purification and characterization
J. Agric. Food Chem.
58
10623-10630
2010
Sepia officinalis
Krause, J.; Tshidino, S.C.; Ogawa, T.; Watanabe, Y.; Oosthuizen, V.; Somai, B.; Muramoto, K.; Naude, R.J.
Purification and partial characterization of ostrich skeletal muscle cathepsin D and its activity during meat maturation
Meat Sci.
87
196-201
2011
Struthio camelus
Bewley, M.A.; Marriott, H.M.; Tulone, C.; Francis, S.E.; Mitchell, T.J.; Read, R.C.; Chain, B.; Kroemer, G.; Whyte, M.K.; Dockrell, D.H.
A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci
PLoS Pathog.
7
e1001262
2011
Homo sapiens
Asuvapongpatana, S.; Saewu, A.; Chotwiwatthanakun, C.; Vanichviriyakit, R.; Weerachatyanukul, W.
Localization of cathepsin D in mouse reproductive tissues and its acquisition onto sperm surface during epididymal sperm maturation
Acta Histochem.
115
425-433
2013
Mus musculus
Menon, V.; Rao, M.
Interactions of a low molecular weight inhibitor from Streptomyces sp. MBR04 with human cathepsin D: implications in mechanism of inactivation
Appl. Biochem. Biotechnol.
174
1705-1723
2014
Homo sapiens
Achour, O.; Bridiau, N.; Kacem, M.; Delatouche, R.; Bordenave-Juchereau, S.; Sannier, F.; Thiery, V.; Piot, J.M.; Maugard, T.; Arnaudin, I.
Cathepsin D activity and selectivity in the acidic conditions of a tumor microenvironment: Utilization in the development of a novel cathepsin D substrate for simultaneous cancer diagnosis and therapy
Biochimie
95
2010-2017
2013
Homo sapiens
Khalkhali-Ellis, Z.; Hendrix, M.J.
Two faces of cathepsin D: physiological guardian angel and pathological demon
Biol. Med. (Aligarh)
6
1000206
2014
Homo sapiens (P07339), Homo sapiens
Graedler, U.; Czodrowski, P.; Tsaklakidis, C.; Klein, M.; Werkmann, D.; Lindemann, S.; Maskos, K.; Leuthner, B.
Structure-based optimization of non-peptidic Cathepsin D inhibitors
Bioorg. Med. Chem. Lett.
24
4141-4150
2014
Homo sapiens (P07339)
Oliveira, C.S.; Pereira, H.; Alves, S.; Castro, L.; Baltazar, F.; Chaves, S.R.; Preto, A.; Corte-Real, M.
Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria
Cell Death Dis.
6
e1788
2015
Saccharomyces cerevisiae, Homo sapiens
Venugopal, A.; Siva Kumar, N.
Biochemical characterization of cathepsin D from the mussel Lamellidens corrianus
Comp. Biochem. Physiol. B
169
25-30
2014
Lamellidens corrianus
Xiao, R.; Zhang, Z.; Wang, H.; Han, Y.; Gou, M.; Li, B.; Duan, D.; Wang, J.; Liu, X.; Li, Q.
Identification and characterization of a cathepsin D homologue from lampreys (Lampetra japonica)
Dev. Comp. Immunol.
49
149-156
2015
Lethenteron camtschaticum (A0A0A7HF39)
Pereira, H.; Azevedo, F.; Rego, A.; Sousa, M.J.; Chaves, S.R.; Corte-Real, M.
The protective role of yeast cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p)
FEBS Lett.
587
200-205
2013
Saccharomyces cerevisiae, Saccharomyces cerevisiae W303-1A
Dong, Z.D.; Zhang, J.; Ji, X.S.; Zhou, F.N.; Fu, Y.; Chen, W.; Zeng, Y.Q.; Li, T.M.; Wang, H.
Molecular cloning, characterization and expression of cathepsin D from grass carp (Ctenopharyngodon idella)
Fish Shellfish Immunol.
33
1207-1214
2012
Ctenopharyngodon idella (K0G3E2), Ctenopharyngodon idella
Follo, C.; Ozzano, M.; Montalenti, C.; Ekkapongpisit, M.; Isidoro, C.
Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-Cathepsin D: functional implications
Int. J. Biochem. Cell Biol.
45
273-282
2013
Homo sapiens (P07339), Homo sapiens, Danio rerio (Q8JH28), Danio rerio
Conus, S.; Pop, C.; Snipas, S.J.; Salvesen, G.S.; Simon, H.U.
Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis
J. Biol. Chem.
287
21142-21151
2012
Homo sapiens
Sun, H.; Lou, X.; Shan, Q.; Zhang, J.; Zhu, X.; Zhang, J.; Wang, Y.; Xie, Y.; Xu, N.; Liu, S.
Proteolytic characteristics of cathepsin D related to the recognition and cleavage of its target proteins
PLoS ONE
8
e65733
2013
Homo sapiens
Zheng, Y.; Chen, H.; Lai, W.; Xu, Q.; Liu, C.; Wu, L.; Maibach, H.I.
Cathepsin D repairing role in photodamaged skin barrier
Skin Pharmacol. Physiol.
28
97-102
2015
Homo sapiens
Zeleznik, T.Z.; Kadin, A.; Turk, V.; Dolenc, I.
Aspartic cathepsin D degrades the cytosolic cysteine cathepsin inhibitor stefin B in the cells
Biochem. Biophys. Res. Commun.
465
213-217
2015
Rattus norvegicus
Butler, V.J.; Cortopassi, W.A.; Gururaj, S.; Wang, A.L.; Pierce, O.M.; Jacobson, M.P.; Kao, A.W.
Multi-granulin domain peptides bind to pro-cathepsin D and stimulate its enzymatic activity more effectively than progranulin in vitro
Biochemistry
58
2670-2674
2019
Homo sapiens
Lim, A.; Doyle, B.L.; Kelly, G.M.; Reed-Bogan, A.M.; Breen, L.H.; Shamlou, P.A.; Lambooy, P.K.
Characterization of a cathepsin D protease from CHO cell-free medium and mitigation of its impact on the stability of a recombinant therapeutic protein
Biotechnol. Prog.
34
120-129
2018
Cricetulus griseus
Ning, M.; Yuan, M.; Liu, M.; Gao, Q.; Wei, P.; Gu, W.; Wang, W.; Meng, Q.
Characterization of cathepsin D from Eriocheir sinensis involved in Spiroplasma eriocheiris infection
Dev. Comp. Immunol.
86
1-8
2018
Eriocheir sinensis
Vangala, G.; Imhoff, F.M.; Squires, C.M.L.; Cridge, A.G.; Baird, S.K.
Mesenchymal stem cell homing towards cancer cells is increased by enzyme activity of cathepsin D
Exp. Cell Res.
383
111494
2019
Homo sapiens
Monickaraj, F.; McGuire, P.; Das, A.
Cathepsin D plays a role in endothelial-pericyte interactions during alteration of the blood-retinal barrier in diabetic retinopathy
FASEB J.
32
2539-2548
2018
Homo sapiens
Yu, C.; Cha, Y.; Wu, F.; Xu, X.; Qin, L.; Du, M.
Molecular cloning and functional characterization of cathepsin D from sea cucumber Apostichopus japonicus
Fish Shellfish Immunol.
70
553-559
2017
Apostichopus japonicus (F6LVS9), Apostichopus japonicus
Kang, T.; Jin, R.; Zhang, Y.; Wan, H.; Lee, K.S.; Jin, B.R.; Li, J.
Functional characterization of the aspartic proteinase cathepsin D in the beet armyworm (Spodoptera exigua)
Gene
617
1-7
2017
Spodoptera exigua (A0A1V0QH26), Spodoptera exigua
Rodriguez-Siordia, I.; Rojo-Arreola, L.; Navarrete Del Toro, M.L.A.; Garcia-Carreno, F.
American lobster Cathepsin D, an aspartic peptidase resistant to proteolysis and active in organic solvents, non-ionic detergents and salts
Int. J. Biol. Macromol.
107
1501-1509
2018
Homarus americanus
Liu, J.; Yang, L.; Tian, H.; Ma, Q.
Cathepsin D is involved in the oxygen and glucose deprivation/reperfusion-induced apoptosis of astrocytes
Int. J. Mol. Med.
38
1257-1263
2016
Mus musculus
Aghdassi, A.A.; John, D.S.; Sendler, M.; Weiss, F.U.; Reinheckel, T.; Mayerle, J.; Lerch, M.M.
Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis
J. Biol. Chem.
293
1018-1029
2018
Mus musculus
Szymczak, M.
Distribution of cathepsin D activity between lysosomes and a soluble fraction of marinating brine
J. Food Sci.
81
E1966-E1970
2016
Clupea harengus
Butler, V.J.; Cortopassi, W.A.; Argouarch, A.R.; Ivry, S.L.; Craik, C.S.; Jacobson, M.P.; Kao, A.W.
Progranulin stimulates the in vitro maturation of pro-cathepsin D at acidic pH
J. Mol. Biol.
431
1038-1047
2019
Homo sapiens
Xu, H.; Bao, K.; Tang, S.; Ai, J.; Hu, H.; Zhang, W.
Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors
J. Pept. Sci.
23
701-706
2017
Homo sapiens
Li, Z.; Bao, K.; Xu, H.; Wu, P.; Li, W.; Liu, J.; Zhang, W.
Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors
J. Pept. Sci.
25
e3154
2019
Homo sapiens
Low, J.D.; Bartberger, M.D.; Chen, K.; Cheng, Y.; Fielden, M.R.; Gore, V.; Hickman, D.; Liu, Q.; Allen Sickmier, E.; Vargas, H.M.; Werner, J.; White, R.D.; Whittington, D.A.; Wood, S.; Minatti, A.E.
Development of 2-aminooxazoline 3-azaxanthene beta-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against cathepsin D
MedChemComm
8
1196-1206
2017
Homo sapiens
Pereira, H.; Oliveira, C.S.; Castro, L.; Preto, A.; Chaves, S.R.; Corte-Real, M.
Yeast as a tool to explore cathepsin D function
Microb. Cell
2
225-234
2015
Saccharomyces cerevisiae, Homo sapiens
Francisco, C.C.; Luis, C.J.; Marina, E.J.; Javier, C.F.; Alexis, L.A.; Del Carmen, S.H.; Alfredo, R.I.
Effect of temperature and pH on the secondary structure and denaturation process of jumbo squid hepatopancreas cathepsin D
Protein Pept. Lett.
26
532-541
2019
Dosidicus gigas
Cocchiaro, P.; Fox, C.; Tregidgo, N.W.; Howarth, R.; Wood, K.M.; Situmorang, G.R.; Pavone, L.M.; Sheerin, N.S.; Moles, A.
Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury
Sci. Rep.
6
27112
2016
Mus musculus
Houben, T.; Oligschlaeger, Y.; Hendrikx, T.; Bitorina, A.V.; Walenbergh, S.M.A.; van Gorp, P.J.; Gijbels, M.J.J.; Friedrichs, S.; Plat, J.; Schaap, F.G.; Luetjohann, D.; Hofker, M.H.; Shiri-Sverdlov, R.
Cathepsin D regulates lipid metabolism in murine steatohepatitis
Sci. Rep.
7
3494
2017
Mus musculus
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