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3.4.23.5: cathepsin D

This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.

Word Map on EC 3.4.23.5

Reaction

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =

Synonyms

BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.5 cathepsin D

Temperature Range

Temperature Range on EC 3.4.23.5 - cathepsin D

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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0 - 50
-
-
20 - 45
-
20°C: about 25% of maximal activity, 45°C: about 60% of maximal activity
20 - 50
-
at 20°C: about 70% of maximum activity, at 50°C: about 30% of maximum activity
27 - 52
-
27°C: about 60% of maximal activity, 52°C: about 60% of maximal activity
30 - 70
-
-
32 - 55
-
32°C: about 50% of maximal activity, 55°C: about 35% of maximal activity
40 - 60
-
40°C: about 65% of maximal activity, 60°C: about 85% of maximal activity
45 - 55
-
about 10% activity at 20°C, about 20% activity at 30°C, about 40% activity at 40°C, about 60% activity at 45°C, 100% activity at 50°C, about 80% activity at 55°C, about 60% activity at 60°C, about 35% activity at 65°C, and about 10% activity at 70°C