3.4.23.5: cathepsin D

This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.

Word Map on EC 3.4.23.5

3.4.23.5

lysosomal

pepstatin

estrogen

metastasis

alzheimer

proteinases

aspartyl

node

vacuole

lymph

renin

pepsin

endosomes

progesterone

hydrolases

endocytic

phagosomes

amyloid

beta-glucuronidase

plasminogen

mannose

6-phosphate

axillary

autophagosomes

saposins

lysosomal-associated

leupeptin

plasmepsins

beta-hexosaminidase

missorting

mannose-6-phosphate

chymosin

lysotracker

lipofuscinosis

lc3-ii

autophagy-lysosomal

rab7

ceroid

estrogen-regulated

immunoradiometric

medicine

lc3

lamp-1

node-negative

trans-golgi

upa

endocytosed

node-positive

c-erbb-2

autolysosomes

cation-independent

molecular biology

Reaction

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =

Synonyms

BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.5 cathepsin D

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Results	in table
9	Activating Compound
1050	AA Sequence
25	Application
1	CAS Registry Number
16	Cloned(Commentary)
6	Crystallization (Commentary)
7459	Disease/ Diagnostics
24	Expression
38	General Information
7	General Stability
75	IC50 Value
293	Inhibitors
51	Ki Value [mM]
97	KM Value [mM]
82	Localization
15	Metals/Ions
122	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
225	Organism
34	PDB ID
74	pH Optimum
18	pH Range
17	pH Stability
14	pI Value
34	Posttranslational Modification
12	Protein Variants
58	Purification (Commentary)
1	Reaction
2	Reaction Type
208	Reference
307	Source Tissue
35	Specific Activity [micromol/min/mg]
11	Storage Stability
364	Substrates and Products (Substrate)
70	Subunits
117	Synonyms
21	Temperature Optimum [°C]
8	Temperature Range [°C]
38	Temperature Stability [°C]
111	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 3.4.23.5 - cathepsin D

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2.2

2.5

2.5 - 3

2.7 - 3.7

hemoglobin

2.8

2.8 - 3

2.9

0.1 M sodium acetate or formate buffer, hydrolysis of hemoglobin

3 - 3.3

hemoglobin

3.1

Oryctolagus cuniculus

bovine hemoglobin

3.2

3.2 - 3.6

hemoglobin

3.3

bovine serum albumin

3.4

3.5

3.6

3.6 - 5

assay at

3.8

4.2

urea-denatured hemoglobin

36929

4.5

Rattus norvegicus

2 optima: pH 3.0 and pH 4.5, hydrolysis of hemoglobin

36933

Tilapia sp.

degradation of endogenous sarcoplasmic proteins

5 - 5.5

5.2 - 6.5

cleavage of bovine aggrecan, within this range, no change in products

653109

5.5 - 6.5

Spisula solidissima

alpha-benzoyl-DL-Arg-p-nitroanilide

36931

additional information

7 entries